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MUT

  • Official Full Name

    methylmalonyl CoA mutase

  • Overview

    This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria.
  • Synonyms

    MUT; methylmalonyl CoA mutase; methylmalonyl Coenzyme A mutase; methylmalonyl-CoA mutase, mitochondrial; mitochondrial; MCM; Methylmalonyl CoA isomerase; Methylmalonyl CoA mutase mitochondrial; Methylmalonyl-CoA isomerase; Methylmalonyl-CoA mutase; MUTA_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MUT-30098TH Recombinant Human MUT Wheat Germ N/A 750 amino acids
Human MUT-920H Recombinant Human MUT Mammalian Cell His
Human MUT-4054HCL Recombinant Human MUT 293 Cell Lysate HEK293 N/A
Human MUT-5762H Recombinant Human MUT Protein, GST-tagged Wheat Germ GST
Human MUT-1678H Recombinant Human MUT protein, His & T7-tagged E.coli His/T7 Val510~Ser749 (Accession # P22033)
Human MUT-3549H-B Recombinant Human MUT Protein Pre-coupled Magnetic Beads HEK293
Human MUT-329HF Recombinant Full Length Human MUT Protein In Vitro Cell Free System 750 amino acids
Human MUT-3549H Recombinant Human MUT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MUT-6579HF Recombinant Full Length Human MUT Protein, GST-tagged In Vitro Cell Free System GST 750 amino acids
Mouse MUT-10264M Recombinant Mouse MUT Protein Mammalian Cell His
Mouse Mut-3256M Recombinant Mouse Mut protein, His-tagged E.coli His 31-748aa
Mouse MUT-5818M Recombinant Mouse MUT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mut-5475M Recombinant Mouse Mut protein, His-tagged Yeast His 31-748aa
Mouse MUT-5818M-B Recombinant Mouse MUT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MUT-2909R Recombinant Rhesus monkey MUT Protein, His-tagged Mammalian Cell His
Rhesus Macaque MUT-2728R Recombinant Rhesus Macaque MUT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MUT-2728R-B Recombinant Rhesus Macaque MUT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MUT-5732Z Recombinant Zebrafish MUT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MUT Related Articles

MUT involved in several pathways and played different roles in them. We selected most pathways MUT participated on our site, such as Valine, leucine and isoleucine degradation, Glyoxylate and dicarboxylate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Valine, leucine and isoleucine degradationAOX2P;BCAT1;HIBADHB;OXCT1;ACADS;PCCA;ACAT1;HADHAA;OXCT2B
Glyoxylate and dicarboxylate metabolismHAO1;GLULA;MDH2;DLDH;GCSHB;GRHPRB;HYI;ACO2;GLULC
Propanoate metabolismACAT2;SUCLG2;BCKDHB;ACSS1;ackA;HADHA;ECHDC1;SUCLG1;MLYCD
Metabolic pathwaysGOT2B;ABO;ACSL1A;INPP4B;QDPR;TK2;GAL3ST1A;NOS2;PLCG2
Carbon metabolismEHHADH;PRPS1;PFKMA;ENO1A;PRPS2;ACO2;AMT;PDHA1B;PGD

MUT has several biochemical functions, for example, cobalamin binding, metal ion binding, methylmalonyl-CoA mutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MUT itself. We selected most functions MUT had, and list some proteins which have the same functions with MUT. You can find most of the proteins on our site.

Function Related Protein
cobalamin bindingMMACHC;TCNL;GIF;LMBRD1;CD320;MUT;TCN2;CUBN;TCN1
metal ion bindingDMRTB1;PCXA;NPEPPS;RORCB;ZNF621;ARHGEF38;COL27A1B;RFNG;ZXDB
methylmalonyl-CoA mutase activity
modified amino acid bindingNOX4;DPEP1;CPS1;MTHFR;CBS;MUT

MUT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUT here. Most of them are supplied by our site. Hope this information will be useful for your research of MUT.

PCBD1; ICT1; Esrrb

Riegger, D; Hai, R; et al. The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA. JOURNAL OF VIROLOGY 89:2241-2252(2015).
Ehrenschwender, M; Bittner, S; et al. XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis. CELL DEATH & DISEASE 5:-(2014).
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