mx1
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  • Official Full Name
  • myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
  • Background
  • In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • MX1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse); myxovirus (influenza) resistance 1, homolog of murine (interferon inducible protein p78); interferon-induced GTP-binding protein Mx1; IFI 78K; MxA; N-terminally processed; Human interferon regulated resistance GTP binding protein MXA; IFI 78; IFI-78K; IFI78; IFI78K; Interferon induced GTP binding protein Mx1; Interferon induced protein p78; Interferon inducible protein p78; Interferon regulated resistance GTP binding protein; Interferon regulated resistance GTP binding protein MxA; Interferon-induced protein p78; Interferon-regulated resistance GTP-binding protein MxA; MX 1; MX; MX1_HUMAN; Myxoma resistance protein 1; Myxovirus (influenza virus) resistance 1 interferon inducible; Myxovirus (influenza virus) resistance 1 interferon inducible protein p78; Myxovirus (influenza) resistance 1 homolog of murine; Myxovirus resistance protein 1
Cat.#:MX1-5771HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MX1 Protein, GST-tagged
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Cat.#:MX1-26961THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MX1
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Cat.#:MX1-10269MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MX1 Protein
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Cat.#:Mx1-1887MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mx1 protein, His & GST-tagged
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Cat.#:Mx1-1888RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mx1 protein, His & GST-tagged
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Cat.#:Mx1-1889RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mx1 protein, His & T7-tagged
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Cat.#:MX1-719CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MX1 Protein, His-tagged
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Cat.#:MX1-2911RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MX1 Protein, His-tagged
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Cat.#:MX1-6177CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MX1
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Cat.#:MX1-4049HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MX1 293 Cell Lysate
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Involved Pathway

MX1 involved in several pathways and played different roles in them. We selected most pathways MX1 participated on our site, such as Measles, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with MX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Measles
IKBKE; HSPA6; CD46; SLAMF1; OAS1; TRAF6; IL1B; CCNE1; NFKBIA; STAT1
Influenza A
HLA-DPB1; IFNA16; CASP1; IFNA12; PIK3R3; MAP2K6; MX1; XPO1; VDAC1; IFNA8

Protein Function

MX1 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MX1 itself. We selected most functions MX1 had, and list some proteins which have the same functions with MX1. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein GNL1; TUBG1; RAP1AA; MXC; SRP54A; RHOJ; ARL4AB; GIMAP2; NUDT2; DNM1L
Function GTPase activity
Related Protein RHOF; EFTUD2; TUBB; RAB23; RAB39BB; RAB25; CDC42; RAP1GAP; RHOJ; GFM2
Function protein binding
Related Protein CHD1; TRAF3; UBE2O; CIB4; FAM117B; TRIM32; MED7; SKIV2L2; NPLOC4; TADA3

Interacting Protein

MX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MX1.
TRPC6; SIAH1; CAB39L; TRPC3; TRPC4; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; TRPC1; TRPC7

MX1 Related Articles

Riegger, D; Hai, R; et al. The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA. JOURNAL OF VIROLOGY 89:2241-2252(2015).
Feng, XB; Huang, J; et al. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. CLINICAL RHEUMATOLOGY 34:71-79(2015).