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MYB

  • Official Full Name

    v-myb myeloblastosis viral oncogene homolog (avian)

  • Overview

    This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
  • Synonyms

    MYB; v-myb myeloblastosis viral oncogene homolog (avian); v myb avian myeloblastosis viral oncogene homolog; transcriptional activator Myb; c myb; c-myb8B_CDS; c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; proto-oncogene c-Myb; c-myb protein (140 AA); efg; Cm;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYB-28009TH Recombinant Human MYB Wheat Germ N/A 640 amino acids
Human MYB-1443H Recombinant Human MYB protein, His & T7-tagged E.coli His/T7 Thr305~Gln558 (Accession # P10242)
Human MYB-4045HCL Recombinant Human MYB 293 Cell Lysate HEK293 N/A
Human MYB-322HF Recombinant Full Length Human MYB Protein In Vitro Cell Free System 640 amino acids
Human MYB-6649HF Recombinant Full Length Human MYB Protein, GST-tagged In Vitro Cell Free System GST 640 amino acids
Human MYB-5777H Recombinant Human MYB Protein, GST-tagged Wheat Germ GST
Human MYB-4635H Recombinant Human MYB Protein (Thr305-Gln558), N-His tagged E.coli N-His Thr305-Gln558
Mouse MYB-10279M Recombinant Mouse MYB Protein Mammalian Cell His
Mouse Myb-1444M Recombinant Mouse Myb protein, His & T7-tagged E.coli His/T7 Lys35~Lys291 (Accession # P06876)
Mouse MYB-5827M Recombinant Mouse MYB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MYB-5827M-B Recombinant Mouse MYB Protein Pre-coupled Magnetic Beads HEK293
Chicken MYB-6858C Recombinant Chicken MYB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MYB Related Articles
  • MYB Related Research Area

MYB involved in several pathways and played different roles in them. We selected most pathways MYB participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
C-MYB transcription factor networkTRIM28;CDKN1B;COL1A2;ELANE;SLC25A3;SMARCA2;CBX4;LECT2;SKI
Factors involved in megakaryocyte development and platelet productionCABLES1;MFN1;H3F3B.1;IRF2;GATA2A;ZFPM2A;KLC3;KIF11;H3F3D
HTLV-I infectionPOLE3;ATM;PIK3CD;HLA-B;TNF;FOS;WNT8B;TBPL2;DVL2
HemostasisAASS;CEACAM1;S100A10A;LOC100514666;CD84;SIRPA;F9B;ANXA2A;BA1
IL2 signaling events mediated by PI3K
IL4-mediated signaling eventsDOK2;IgG3;CCL26;RETNLB;MYB;IRF4;EGR2;PARP14;TFF3
Neural Crest DifferentiationDMBX1;ASCL1;OLIG2;GBX2;PMP22;TXLNB;LHX2;LHX1;PHOX2B
Notch-mediated HES/HEY networkMYB;GATA1;GATA6;YY1;HEY1;BGLAP;MYOD1;ASCL1;RCAN1

MYB has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, WD40-repeat domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYB itself. We selected most functions MYB had, and list some proteins which have the same functions with MYB. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingZFP746;ZFP536;ZNF264;POU4F2;MED1;DLX5;FOSB;CTCF;CDX4
WD40-repeat domain bindingUSP47;CDC5L;MYB
protein bindingFLII;OSBPL3;CLDN7;CD58;TXNRD3;SHMT1;EFS;TNFAIP8L2;CXCR4
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNKX2;SIX1;RELA;FOXJ1;MEOX1;BARHL2;ALS2CR8;TRP53;STK16

MYB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYB here. Most of them are supplied by our site. Hope this information will be useful for your research of MYB.

SUMO2; SUMO1; ERC2; CLTC; KIF2A; PCDH17; SETD1A; NCAM2; ZFC3H1; NCOR1; PTMS

Wang, Z; Fan, C; et al. S5a binds to death receptor-6 to induce THP-1 monocytes to differentiate through the activation of the NF-kappa B pathway. JOURNAL OF CELL SCIENCE 127:3257-3268(2014).
Afroze, T; Yang, G; et al. Calcium Efflux Activity of Plasma Membrane Ca2+ ATPase-4 (PMCA4) Mediates Cell Cycle Progression in Vascular Smooth Muscle Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:7221-7231(2014).
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