myh11
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  • Official Full Name
  • myosin, heavy chain 11, smooth muscle
  • Background
  • The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product;is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light;chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through;the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this;gene, and its 3 end overlaps with that of the latter. The pericentric inversion of chromosome 16 (inv(16)(p13q22));produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of;core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This;chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing;generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation.;Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • MYH11; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 11, smooth muscle; myosin-11; SMHC; SMMHC; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; AAT4; FAA4; FLJ35232; MGC32963; MGC126726; DKFZp686D10126; DKFZp686D19237
Cat.#:MYH11-1132HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYH11, His-tagged
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Cat.#:Myh11-8024RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Myh11 protein, His-tagged
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Cat.#:MYH11-6826CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYH11
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Involved Pathway

MYH11 involved in several pathways and played different roles in them. We selected most pathways MYH11 participated on our site, such as Vascular smooth muscle contraction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYH11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vascular smooth muscle contraction
PLA2G3; PRKACAA; PTGIR; ROCK2; GNA11A; PPP1R12B; PLA2G2A; RAF1A; CALM3A; CACNA1D
Tight junction
SYMPK; PRKCQ; JAM3; MPDZ; OCLNA; ACTN3B; CLDN4; MPP5A; ACTN4; PPP2CB

Protein Function

MYH11 has several biochemical functions, for example, ATP binding, actin filament binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYH11 itself. We selected most functions MYH11 had, and list some proteins which have the same functions with MYH11. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE1Y1; MAPK1; UBE2W; HSPA6; BAZ1B; SPATA5L1; ACSBG1; NMNAT3; FGFR4; PLK4
Function actin filament binding
Related Protein USH1C; FLNA; SHROOM3; TNNC1; AJUBA; FSCN2B; CORO1CA; NEBL; HAND2; SVILA
Function calmodulin binding
Related Protein SLC14A2; CAMSAP1L1; NETO2; RGS2; ENKUR; CAMKK1; MAP6D1; CDK5RAP2; PHKG1; MAPKAPK5
Function motor activity
Related Protein MYO7B; MYH1; MYH9; MYO1E; KIF2A; DCTN1; VMHC; MYO6A; DNAI1; MYHZ1.2
Function protein binding
Related Protein IGSF1; TXNL4A; BIRC5; DTD2; MRPL10; LGALS8; PPP1R12B; RAD51L3; NSMAF; CCBL1
Function structural constituent of muscle
Related Protein ACTN2; MYL6; MYL1; MYBPH; SMTN; CSRP3; MYL5; CAPN3; OBSCN; MYBPC2

Interacting Protein

MYH11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYH11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYH11.
MYL12B; WRAP73; GAMMAHV.ORF40; APC; GRB2; DAXX; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; TBC1D31; ARPC5; SVIL; C4BPA; FLNA; CAPZB; MYL6; ACTR3; YWHAE; YWHAZ; UBXN2A; GTF2B

MYH11 Related Articles

Chen, XY; Li, R; et al. Identification of differentially expressed genes in hypothalamus of chicken during cold stress. MOLECULAR BIOLOGY REPORTS 41:2243-2248(2014).
Gonzalez, L; Eiro, N; et al. Clinical significance of myosin in colorectal cancer. ANNALS OF DIAGNOSTIC PATHOLOGY 16:260-266(2012).