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MYOC

  • Official Full Name

    myocilin, trabecular meshwork inducible glucocorticoid response

  • Overview

    MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
  • Synonyms

    MYOC; myocilin, trabecular meshwork inducible glucocorticoid response; GLC1A; myocilin; JOAG1; TIGR; mutated trabecular meshwork-induced glucocorticoid response protein; GPOA; JOAG;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYOC-28653TH Recombinant Human MYOC Wheat Germ N/A 504 amino acids
Human MYOC-29758TH Recombinant Human MYOC Wheat Germ N/A 100 amino acids
Human MYOC-6991H Recombinant Human MYOC protein, His-tagged HEK293 His Arg33-Met504
Human MYOC-1837HCL Recombinant Human MYOC cell lysate Human Cell N/A
Human MYOC-4655H Recombinant Human MYOC Protein (Ile227-Met504), C-His tagged Mammalian cells C-His Ile227-Met504
Human MYOC-5849H Recombinant Human MYOC Protein, GST-tagged Wheat Germ GST
Human MYOC-326HF Recombinant Full Length Human MYOC Protein In Vitro Cell Free System 504 amino acids
Human MYOC-2502H Recombinant Human MYOC Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MYOC-4656H Recombinant Human MYOC Protein (Ala224-Tyr471), His tagged E.coli His Ala224-Tyr471
Human MYOC-1196H Recombinant Human MYOC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MYOC-6605HF Recombinant Full Length Human MYOC Protein, GST-tagged In Vitro Cell Free System GST 504 amino acids
Human MYOC-800H Recombinant Human MYOC Protein, His-tagged E.coli His Ala224~Tyr471
Human MYOC-824H Recombinant Human MYOC Protein HEK293 504
Human MYOC-1469H Recombinant Human MYOC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MYOC-296HFL Recombinant Full Length Human MYOC Protein, C-Flag-tagged Mammalian cells Flag
Human MYOC-1469H-B Recombinant Human MYOC Protein Pre-coupled Magnetic Beads HEK293
Mouse MYOC-10347M Recombinant Mouse MYOC Protein Mammalian Cell His
Mouse Myoc-1257M Recombinant Mouse Myoc protein, His-tagged Yeast His 213-490aa
Mouse MYOC-5863M Recombinant Mouse MYOC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MYOC-5863M-B Recombinant Mouse MYOC Protein Pre-coupled Magnetic Beads HEK293
Mouse Myoc-1306M Recombinant Mouse Myoc protein, His&Myc-tagged HEK293 His&Myc 213-490aa
Mouse Myoc-4261M Recombinant Mouse Myoc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Myoc-4401M Recombinant Mouse Myoc protein, His-tagged E.coli His 213-490aa
Mouse Myoc-4402M Recombinant Mouse Myoc protein, His&Myc-tagged Insect Cell His&Myc 213-490aa
Rat MYOC-3869R Recombinant Rat MYOC Protein Mammalian Cell His
Rat MYOC-3528R Recombinant Rat MYOC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MYOC-3528R-B Recombinant Rat MYOC Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MYOC-2307Z Recombinant Zebrafish MYOC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MYOC Related Articles
  • MYOC Related Research Area

MYOC involved in several pathways and played different roles in them. We selected most pathways MYOC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYOC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MYOC has several biochemical functions, for example, fibronectin binding, frizzled binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYOC itself. We selected most functions MYOC had, and list some proteins which have the same functions with MYOC. You can find most of the proteins on our site.

Function Related Protein
fibronectin bindingFSTL3;SFRP2;IGFBP3;SDC4;IGFBP5;CCDC80;IGFBP5A;LRRC15;ITGA4
frizzled bindingNDP;WNT4;WNT4A;WNT9B;WNT10B;CTHRC1;SDCBP;WNT3A;DVL1B
metal ion bindingZNF302;NR1D4A;NRP1B;RXRGB;CYP2F2;NDUFV2;NENF;ZNF621;ZBTB10
myosin light chain bindingCXCR4;MYO19;SPATA6;MYOC
protein bindingPTH1R;YIF1A;UBLCP1;INMT;RALYL;NUAK1;NKD2;AIM2;RANBP6
receptor tyrosine kinase bindingPITPNM3;FNTA;MYOC;PCNA;PLCG1;PTPN1;SQSTM1;NRG3;Flt3l

MYOC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYOC here. Most of them are supplied by our site. Hope this information will be useful for your research of MYOC.

Goldwich, A; Scholz, M; et al. Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells. HISTOCHEMISTRY AND CELL BIOLOGY 131:167-180(2009).
Tawara, A; Tou, N; et al. Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 246:1021-1028(2008).
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