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Marco

  • Official Full Name

    macrophage receptor with collagenous structure

  • Overview

    Macrophage receptor MARCO is a protein that in humans is encoded by the MARCO gene. The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an intracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
  • Synonyms

    MARCO; SCARA2; Macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO_HUMAN; Scavenger receptor class A member 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MARCO-5940H Active Recombinant Human MARCO protein, His-tagged CHO His
Human MARCO-750H Recombinant Human MARCO, His-tagged E.coli His C-term-350aa
Human MARCO-5235H Recombinant Human MARCO Protein (Met79-Val520), N-His tagged E.coli N-His Met79-Val520
Human MARCO-2149H Recombinant Human MARCO protein, His-tagged HEK293 His Met 79 - Val 520
Mouse Marco-589M Active Recombinant Mouse Marco protein, His-tagged Mammalian cells His
Mouse Marco-2229M Recombinant Mouse Marco, His tagged Human Cell His
Mouse Marco-7944M Recombinant Mouse Marco protein, His & T7-tagged E.coli His/T7 Gly366~Ser518 (Accession # Q60754)
Mouse MARCO-2563MCL Recombinant Mouse MARCO cell lysate Human Cell N/A
Mouse MARCO-2163M Recombinant Mouse MARCO protein, His-tagged HEK293 His Gln70-Ser518
Mouse Marco-5371M Recombinant Mouse Marco Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MARCO-2208M Recombinant Mouse MARCO protein, His-tagged HEK293 His Gln 421 - Ser 518
Mouse Marco-5371M-B Recombinant Mouse Marco Protein Pre-coupled Magnetic Beads HEK293
Mouse MARCO-0516M Recombinant Mouse MARCO protein, His-tagged HEK293 His Gln70-Ser518
Rat Marco-7945R Recombinant Rat Marco protein, His & T7-tagged E.coli His/T7 Gly367~Arg519 (Accession # M0R9F7)
Cynomolgus MARCO-2156C Recombinant Cynomolgus MARCO protein, His-tagged HEK293 His Met 79 - Ile 520
Chicken MARCO-6301C Recombinant Chicken MARCO Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Marco Related Articles
  • Marco Related Research Area

Marco involved in several pathways and played different roles in them. We selected most pathways Marco participated on our site, such as Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Marco were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTUBB2A;SEC22B;CALR;ATP6V0CA;TUBA3A;TUBA4A;RAB5B;RAB5C;ATP6V0D2

Marco has several biochemical functions, for example, scavenger receptor activity, signaling pattern recognition receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Marco itself. We selected most functions Marco had, and list some proteins which have the same functions with Marco. You can find most of the proteins on our site.

Function Related Protein
scavenger receptor activityVTNA;SCARF2;VTNB;ENPP1;PGBD1;PRG4;SCARA5;LOXL2;PRSS12
signaling pattern recognition receptor activityCLEC7A;MARCO;FCN1;TLR2;DMBT1;TRIM5;COLEC12
transmembrane signaling receptor activityKLRD1;CD79B;Fzd4;EDAR;RYK;M6PR;OR12D2;FZD3B;CLEC2D

Marco has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Marco here. Most of them are supplied by our site. Hope this information will be useful for your research of Marco.

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Verschoor, CP; Dorrington, MG; et al. MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx. INFECTION AND IMMUNITY 82:4824-4833(2014).
Majumder, PP; Sarkar-Roy, N; et al. Genomic correlates of variability in immune response to an oral cholera vaccine. EUROPEAN JOURNAL OF HUMAN GENETICS 21:1000-1006(2013).
  • Q&As
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