MLH1
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Official Full Name
mutL homolog 1
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Overview
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009] -
Synonyms
MLH1; mutL homolog 1; FCC2; COCA2; HNPCC; hMLH1; HNPCC2; DNA mismatch repair protein Mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- MLH1 Related Articles
- MLH1 Related Research Area
MLH1 involved in several pathways and played different roles in them. We selected most pathways MLH1 participated on our site, such as Mismatch repair, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Mismatch repair | MSH6;RFC5;PCNA;POLD4;MSH2;EXO1;MLH1;RPA3;RFC1 |
Fanconi anemia pathway | APITD1;EME1;ATRIP;RPA1;RPA4;ERCC4;TOP3A;HER9;POLK |
Pathways in cancer | ARHGEF1;IGF1R;LAMA4;GNAQ;WNT8B;F2RL3;MAP2K2;LPAR6;PTGER1 |
Colorectal cancer | AKT2;RHOA;BRAF;Casp3;ARAF;MSH3;PIK3CG;LEF1;TCF7L2 |
Endometrial cancer | BAD;TCF7;HRAS;CASP9;MAPK3;MAPK1;PDPK1;AXIN2;NRAS |
MLH1 has several biochemical functions, for example, ATP binding, ATPase activity, contributes_to MutSalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLH1 itself. We selected most functions MLH1 had, and list some proteins which have the same functions with MLH1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MAP2K2A;ABCB6;TGFBR2;NME3;RPS6KA4;PKDCCA;NLRX1;MAT2AL;ACTR8 |
ATPase activity | DNAH11;DYNC2H1;ABCG2A;ABCA4;ATAD2B;VCP;KIFC2;ABCG2D;DYNC1H1 |
contributes_to MutSalpha complex binding | PMS2;MLH1 |
mismatched DNA binding | MSH5;PMS1;MSH6;MSH4;MLH3;MLH1;TDG |
protein binding | BORA;ERCC1;TMBIM6;SMARCD1;EXOC3;UNC45B;TGIF1;SLC4A4;NRXN1 |
contributes_to protein binding | INTS10;TGFBR3;TAF10;MEF2A;INHA;ACVR2A;CPSF3L;MLH1;CRY1A |
contributes_to single-stranded DNA binding | MSH3;POLR2D;MSH2;PMS2;MLH1;IGHM;IGJ |
MLH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLH1.
PMS2; TMSB4X
- Q&As
- Reviews
Q&As (7)
Ask a questionGermline mutations in MLH1 are linked to Lynch syndrome, increasing the risk of various cancers.
MLH1 helps prevent the development of colorectal and other hereditary cancers by maintaining DNA integrity.
Changes in MLH1 function can influence the effectiveness of certain chemotherapies in treating cancer.
MLH1 plays a role in the cellular response to DNA damage, maintaining replication accuracy.
MLH1 deficiency results in microsatellite instability, a hallmark of certain types of cancer.
MLH1 is essential for DNA mismatch repair, ensuring genomic stability by correcting replication errors.
MLH1 modulates apoptosis in cells with DNA damage, preventing the proliferation of damaged cells.
Customer Reviews (3)
Write a reviewTimely protein expression optimization, greatly boosts our research.
Accurate protein structural analysis, a cornerstone of our investigations.
Precise antibody validation, enhances our immunoprecipitation accuracy.
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