MMP7
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Official Full Name
matrix metallopeptidase 7 (matrilysin, uterine)
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Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] -
Synonyms
MMP7; matrix metallopeptidase 7 (matrilysin, uterine); MMP-7; MPSL1; PUMP-1; matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine); MAT;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Rat
- 293F
- CHO
- E. coli
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse myeloma cell line NS0
- Wheat Germ
- Yeast
- C
- His
- Fc
- GST
- His (Fc)
- Avi
- His|T7
- N/A
- N
- SUMO
- TG
- 8H
- GGQ
- Involved Pathway
- Protein Function
- Interacting Protein
- MMP7 Related Articles
- MMP7 Related Gene Family
- MMP7 Related Research Area
MMP7 involved in several pathways and played different roles in them. We selected most pathways MMP7 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Wnt signaling pathway | WNT5A;GSK3AA;FZD7A;FZD9;NLK2;RAC3A;FBXW11B;RAC3B;CAMK2B1 |
MMP7 has several biochemical functions, for example, heparin binding, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP7 itself. We selected most functions MMP7 had, and list some proteins which have the same functions with MMP7. You can find most of the proteins on our site.
Function | Related Protein |
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heparin binding | REG4;COMP;FGFRL1;WISP2;LRPAP1;SAA1;APOB;TENM1;APLP2 |
metalloendopeptidase activity | ADAM20;BMP1;ADAMTS1;Adam6;ADAMTS5;OMA1;MMP23BB;BMP1A;FAP |
zinc ion binding | ZFP276;BMI1B;RNF181;PRICKLE1B;RBM4B;PDZRN4;CA13;PPARAB;RNF220 |
MMP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP7.
ELN; FASLG
- Q&As
- Reviews
Q&As (6)
Ask a questionMMP7 overexpression has been linked to various diseases, including cancer, inflammatory disorders, and tissue fibrosis.
MMP7 is involved in the degradation of extracellular matrix components during inflammation, influencing tissue damage and repair processes.
Developing specific inhibitors that target MMP7 activity is a potential approach for therapeutic interventions, particularly in diseases where MMP7 plays a detrimental role.
Several MMP inhibitors have been investigated, and some show promise in controlling MMP7 activity. However, their clinical use is still under research.
MMP7 facilitates cancer cell invasion and metastasis by degrading the extracellular matrix, allowing cancer cells to invade surrounding tissues and spread to distant organs.
Yes, elevated levels of MMP7 have been observed in the serum or tissues of cancer patients, making it a potential biomarker for certain types of cancer.
Customer Reviews (3)
Write a reviewThis includes rigorous quality control measures to ensure the consistency and purity of the protein, thereby reducing variability in the experimental outcomes.
by utilizing MMP7 protein in trials and collaborating with a supportive manufacturer, researchers can gain access to a versatile tool that can aid in their understanding of angiogenesis and vascular biology.
With expert assistance and reliable product quality, researchers can conduct their experiments with confidence, enabling them to contribute to advancements in the field and potentially improve future therapeutic interventions.
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