MMP9
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Official Full Name
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
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Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008] -
Synonyms
MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); B/MMP9; AW743869; pro-MMP-9;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bovine
- Cattle
- Chicken
- Cynomolgus Monkey
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human Blood
- Human Cell
- Human Neutrophil
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Yeast(Pichia pastor)
- C
- 6×His
- His
- Flag
- GST
- His (Fc)
- Avi
- His(C
- ter)
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- MMP9 Related Articles
MMP9 involved in several pathways and played different roles in them. We selected most pathways MMP9 participated on our site, such as TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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TNF signaling pathway | SELE;BCL3;CREB3L2;RIPK1;PGAM5;PIK3R2;MAPK1;CXCL2;CCL20 |
Leukocyte transendothelial migration | CLDN14;GNAI2;PIK3CG;GNAI1;CLDN6;CTNNA3;ITGA4;CLDN11;RAP1B |
Estrogen signaling pathway | GRB2;CREB3L1;SHC2;SRC;PLCB3;SHC3;GNAO1;SP1;PRKACB |
Hepatitis B | IFNA14;CXCL8;IRF3;MAPK3;STAT1;SMAD3;BCL2;CCND1;PIK3CG |
Pathways in cancer | FGF22;FGFR1;MITF;WNT8B;PTEN;ETS1;GNB4;CSF1R;LAMB4 |
Transcriptional misregulation in cancer | NR4A3;IL-8;MLLT3;PER2;SFPI1;NUPR1;FCGR1A;SIX1;CD40 |
Proteoglycans in cancer | WNT6;SMAD2;ANK1;PTK2;SRC;PRKACA;FZD3;HIF1A;PRKACG |
MicroRNAs in cancer | APC;EP300;TNR;DDIT4;KIF23;BMI1;EFNA3;MTOR;WNT3A |
Bladder cancer | MAPK1;MMP1;ERBB2;CCND1;BRAF;TP53;MAP2K1;CDH1;MMP1A |
MMP9 has several biochemical functions, for example, collagen binding, endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP9 itself. We selected most functions MMP9 had, and list some proteins which have the same functions with MMP9. You can find most of the proteins on our site.
Function | Related Protein |
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collagen binding | TLL1;C1QTNF1;COMP;GPR56;FN1;CTSS;MRC2;PCOLCE;GP6 |
endopeptidase activity | SENP3B;CPS1;KLK1B11;PSMA6B;KLK1B22;CTSH;ADAMTS3;NAPSA;PSMA6 |
identical protein binding | APOA1;DRD2;GRASP;SIAH1;MCM6;VWA1;CDC42;CLDN4;ATF3 |
metalloendopeptidase activity | PMPCB;ADAM12;YBEY;ADAMTS16;OSGEPL1;MMP14B;MMP14;ADAMTS2;ADAMTS18 |
metallopeptidase activity | PAPPA;CPD;ENPEP;ADAM9;AQPEP;CLCA2;PAPPA2;DPEP3;ADAMTS1 |
protein binding | PRMT5;G3BP2;TMEM25;ATP5A1;STAP2;MYBPHL;TADA2A;FNBP1;FBXL8 |
zinc ion binding | ZDHHC8B;SH3RF3;NR5A1;TRIM4;Adamts19;LONRF2;TRIM37;RNF149;ZNF598 |
MMP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP9.
VCAN; MEP1A; MEP1B; TIMP1; SRGN; ELN; SCUBE3; TGFB1; q7cje7_yerpe; ITGA5
- Q&As
- Reviews
Q&As (5)
Ask a questionDysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.
Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.
MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.
MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.
MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.
Customer Reviews (3)
Write a reviewThe superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.
Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.
Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.
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