MPO
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Official Full Name
myeloperoxidase
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Overview
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008] -
Synonyms
MPO; myeloperoxidase;
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cattle
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- Human Cells
- Human Neutrophil
- Human Sputum
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Neutrophils
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MPO Related Research Area
MPO involved in several pathways and played different roles in them. We selected most pathways MPO participated on our site, such as Phagosome, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ATP6AP1B;SCARB1;HLA-C;TUBA3D;CTSLA;RAC1A;OLR1;TUBA2;C3 |
| Transcriptional misregulation in cancer | HMGA2;SPI1;CCND2;MAF;FLI1;DDX5;CD14;RUNX1;KDM6A |
MPO has several biochemical functions, for example, chromatin binding, heme binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MPO itself. We selected most functions MPO had, and list some proteins which have the same functions with MPO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | PHF13;PDX1;TRP53;SMC1A;TOX3;ZKSCAN3;CHD7;BRD4;WAC |
| heme binding | CYGB2;CYP2C39;TDO2A;CYP46A1;CYP2N13;CYP27C1;Adgb;JAK2;SUOX |
| heparin binding | FGF9;FGF14;CCDC80;APPB;UBE4A;FGFR1A;FMOD;FGFBP1;PDCD5 |
| metal ion binding | ZKSCAN6;CDKN1A;GTF2E1;NMRK1;CYP2AA4;ZSCAN23;PLEKHF2;TEC;PFKMB |
| peroxidase activity | PTGS2;MGST3;MPX;GPX4B;GPX1B;GPX7;IPCEF1;GPX6;PRDX1 |
MPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPO here. Most of them are supplied by our site. Hope this information will be useful for your research of MPO.
Dynll1; ssrna_ug
- Q&As
- Reviews
Q&As (5)
Ask a questionMPO is synthesized and stored by granulocytes in the bone marrow.
MPO mediates the production of halogenated oxidants in phagosomes and plays a key role in bacterial killing and protecting the body from disease.
Under physiological conditions in the body, MPO catalyzes the production of hypochlorous acid.
MPO can be used as a marker for cerebral stroke.
MPO has been associated with studies of diseases such as leukemia and coronary heart disease.
Customer Reviews (3)
Write a reviewThe technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.
The MPO proteins purchased from your company is suitable for WB.
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