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MPZL2

Official Full Name

myelin protein zero-like 2
Overview

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene.
Synonyms

MPZL2; myelin protein zero-like 2; epithelial V like antigen 1 , EVA1; myelin protein zero-like protein 2; EVA; Epithelial V like antigen 1; EVA1; MPZL2 myelin protein zero like 2; Myelin protein zero like protein 2; epithelial V-like antigen 1;

Type

Cell & Tissue Lysates
Recombinant Proteins

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)

Source

E.coli expression system
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MPZL2-4217HCL	Recombinant Human MPZL2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MPZL2-5526H	Recombinant Human MPZL2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MPZL2-3214H	Recombinant Human MPZL2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MPZL2-6339HF	Recombinant Full Length Human MPZL2 Protein, GST-tagged	In Vitro Cell Free System	GST	215 amino acids	Inquiry
Mouse	Mpzl2-982M	Recombinant Mouse Mpzl2 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Homo sapiens (Human)	RFL4191HF	Recombinant Full Length Human Myelin Protein Zero-Like Protein 2(Mpzl2) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (27-215)	Inquiry
Mus musculus (Mouse)	RFL28593MF	Recombinant Full Length Mouse Myelin Protein Zero-Like Protein 2(Mpzl2) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (27-215)	Inquiry
Chicken	MPZL2-4566C	Recombinant Chicken MPZL2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MPZL2 Related Articles
MPZL2 Related Research Area

MPZL2 involved in several pathways and played different roles in them. We selected most pathways MPZL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MPZL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MPZL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MPZL2 itself. We selected most functions MPZL2 had, and list some proteins which have the same functions with MPZL2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	CD37;FYTTD1;TBP;BOK;CTNNA2;PINK1;ABCG8;PYDC1;NT5C2

MPZL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPZL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MPZL2.

MPZL3; ATF4; MEST; b3xyc5_sollc

Wang, FF; Wang, L; et al. PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells. MOLECULAR MEDICINE REPORTS 11:698-704(2015).

Nakata, H; Wakayama, T; et al. Compensatory Upregulation of Myelin Protein Zero-Like 2 Expression in Spermatogenic Cells in Cell Adhesion Molecule-1-Deficient Mice. ACTA HISTOCHEMICA ET CYTOCHEMICA 45:47-56(2012).

Multiple Sclerosis and Myelin Related Molecules