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MRAP

Official Full Name

melanocortin 2 receptor accessory protein
Overview

This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described.
Synonyms

MRAP; melanocortin 2 receptor accessory protein; C21orf61, chromosome 21 open reading frame 61; melanocortin-2 receptor accessory protein; B27; FALP; fat tissue-specific low MW protein; fat cell-specific low molecular weight protein; FGD2; GCCD2; C21orf6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A
N
hFc

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRAP-683H	Recombinant Human MRAP protein(Tyr59-Ser172), hFc-tagged	HEK293	N-hFc	Tyr59-Ser172	Inquiry
Human	MRAP-1131HCL	Recombinant Human MRAP cell lysate		N/A		Inquiry
Human	MRAP-5530H	Recombinant Human MRAP Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MRAP-1436H	Recombinant Human MRAP Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MRAP-6341HF	Recombinant Full Length Human MRAP Protein, GST-tagged	In Vitro Cell Free System	GST	172 amino acids	Inquiry
Mouse	MRAP-10009M	Recombinant Mouse MRAP Protein	Mammalian Cell	His		Inquiry
Mouse	MRAP-5662M-B	Recombinant Mouse MRAP Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MRAP-5662M	Recombinant Mouse MRAP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Mrap-4133M	Recombinant Mouse Mrap Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MRAP Related Articles

MRAP involved in several pathways and played different roles in them. We selected most pathways MRAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MRAP has several biochemical functions, for example, corticotropin hormone receptor binding, protein binding, type 1 melanocortin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRAP itself. We selected most functions MRAP had, and list some proteins which have the same functions with MRAP. You can find most of the proteins on our site.

Function	Related Protein
corticotropin hormone receptor binding	MRAP;MRAP2
protein binding	NDC80;BCL2L12;GDF2;PLK3;TRDN;TUSC2;STX6;MOBKL1A;HBD
type 1 melanocortin receptor binding	POMC;AGRP2;MRAP;MRAP2
type 3 melanocortin receptor binding	a;ASIP;MRAP2;MRAP;POMC
type 4 melanocortin receptor binding	ASIP;MRAP;a;POMC;MRAP2
type 5 melanocortin receptor binding	MRAP2;MRAP

MRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of MRAP.

MRAP2; MC4R; MC5R; MC3R; MC1R

Johnson, SR; Swinton, JR; et al. Prognostic factors for survival in scleroderma associated pulmonary arterial hypertension. JOURNAL OF RHEUMATOLOGY 35:1584-1590(2008).

Sebag, JA; Hinkle, PM; et al. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104:20244-20249(2007).