Msr1
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Official Full Name
macrophage scavenger receptor 1
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Overview
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. -
Synonyms
MSR1; macrophage scavenger receptor 1; macrophage scavenger receptor types I and II; CD204; SCARA1; scavenger receptor class A member 1; scavenger receptor class A, member 1; macrophage scavenger receptor type III; macrophage acetylated LDL receptor I and; SRA; SR-A; phSR1; phSR2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Human cells
- Insect Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Fc
- GST
- GST|His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- hFc
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- Msr1 Related Research Area
Msr1 involved in several pathways and played different roles in them. We selected most pathways Msr1 participated on our site, such as Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Msr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | ITGB1B.2;ATP6V1B2;TUBA8L3;TUBA8L4;HBL4;BLB1;C3A.1;ATP6V1C2;TUBA1L |
Msr1 has several biochemical functions, for example, low-density lipoprotein particle binding, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Msr1 itself. We selected most functions Msr1 had, and list some proteins which have the same functions with Msr1. You can find most of the proteins on our site.
Function | Related Protein |
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low-density lipoprotein particle binding | LDLR;MSR1;ANKRA2;SCARB1;LIPC;SCARF1;COLEC12;CRP;THBS1 |
protein binding | TIMP1;MRPS23;CDC14B;IMPA2;RIMS1;LBX1;KLF2;DNAJC5B;IL28RA |
scavenger receptor activity | MARCO;VTNA;CFI;TMPRSS4A;ENPP1;CCBP2;LOXL2;CD5;C8orf84 |
Msr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Msr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Msr1.
ATP6V0C; MALL; NKG7; LEPROTL1; SEC22A; HOOK3; Hook3
- Q&As
- Reviews
Q&As (5)
Ask a questionMSR1 (Macrophage Scavenger Receptor 1) is involved in the recognition and clearance of modified low-density lipoproteins (LDL) by macrophages, playing a critical role in lipid homeostasis.
MSR1 contributes to the resolution of inflammation by promoting the clearance of apoptotic cells and debris. Its anti-inflammatory effects involve modulating cytokine production and signaling.
MSR1 participates in antigen presentation by macrophages, influencing T-cell activation. This role connects MSR1 to adaptive immune responses.
MSR1 is involved in the clearance of amyloid-beta peptides associated with neurodegenerative diseases such as Alzheimer's. Its role in phagocytosis and clearance is crucial in the context of neuroinflammation.
MSR1 modulates the immune response by regulating inflammatory signaling pathways. Its involvement in recognizing modified LDL in atherosclerotic plaques links it to inflammation and atherosclerosis.
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