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Msr1

  • Official Full Name

    macrophage scavenger receptor 1

  • Overview

    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
  • Synonyms

    MSR1; macrophage scavenger receptor 1; macrophage scavenger receptor types I and II; CD204; SCARA1; scavenger receptor class A member 1; scavenger receptor class A, member 1; macrophage scavenger receptor type III; macrophage acetylated LDL receptor I and; SRA; SR-A; phSR1; phSR2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • Insect Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • hFc
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MSR1-30164TH Recombinant Human MSR1 Wheat Germ N/A 100 amino acids
Human MSR1-44H Recombinant Human MSR1 protein, T7/His-tagged E.coli T7/His
Human MSR1-872H Recombinant Human MSR1 protein, His-tagged HEK293 His Lys77-Leu451
Human MSR1-53H Recombinant Human MSR1 protein, His-tagged Insect Cell His
Human MSR1-743H Recombinant Human MSR1 Protein, GST-His-tagged E.coli GST/His
Human MSR1-2844HCL Recombinant Human MSR1 cell lysate Human Cell N/A
Human MSR1-1258H Recombinant Human MSR1 Protein (Lys77-Val350), N-His tagged E.coli N-His Lys77-Val350
Human MSR1-2090H Recombinant Human MSR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MSR1-4609H Recombinant Human MSR1 Protein (Lys77-Leu451), C-His tagged Mammalian cells C-His Lys77-Leu451
Human MSR1-01H Active Recombinant Human MSR1 Protein, Fc-tagged Human cells Fc 77-451
Human MSR1-5664H Recombinant Human MSR1 Protein, GST-tagged Wheat Germ GST
Human MSR1-4006H Recombinant Human MSR1 protein, His-tagged E.coli His 78-253 aa
Human MSR1-2026H Recombinant Human MSR1 Protein, His-tagged HEK293 His Lys77-Leu451
Human MSR1-1793H Recombinant Human MSR1 Protein, His&GST-tagged E.coli N-His&GST Ala52-Asn221
Human MSR1-2652H Recombinant Human MSR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MSR1-103H Recombinant Human MSR1 Protein, His-tagged E.coli His
Human MSR1-385H Recombinant Human MSR1 Protein, His-tagged HEK293 His 451
Mouse Msr1-171M Active Recombinant Mouse Msr1, His-tagged Mammalian cells His
Mouse Msr1-3275M Recombinant Mouse Msr1 protein, His-tagged HEK293 His Trp83-Val354
Mouse MSR1-2288MCL Recombinant Mouse MSR1 cell lysate Human Cell N/A
Mouse Msr1-5750M Recombinant Mouse Msr1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Msr1-4195M Recombinant Mouse Msr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Msr1-5750M-B Recombinant Mouse Msr1 Protein Pre-coupled Magnetic Beads HEK293
Rat Msr1-8792R Recombinant Rat Msr1 protein(Trp79-Ser454), hFc-tagged HEK293 N-hFc Trp79-Ser454
Rat Msr1-38R Recombinant Rat Msr1, His tagged Human Cell His
Rat MSR1-800RCL Recombinant Rat MSR1 cell lysate Human Cell N/A
Bos taurus (Bovine) RFL30618BF Recombinant Full Length Bovine Macrophage Scavenger Receptor Types I And Ii(Msr1) Protein, His-Tagged E.coli expression system His Full Length (1-453)
Homo sapiens (Human) RFL29088HF Recombinant Full Length Human Macrophage Scavenger Receptor Types I And Ii(Msr1) Protein, His-Tagged E.coli expression system His Full Length (1-451)
Mus musculus (Mouse) RFL1120MF Recombinant Full Length Mouse Macrophage Scavenger Receptor Types I And Ii(Msr1) Protein, His-Tagged E.coli expression system His Full Length (1-458)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Msr1 Related Research Area

Msr1 involved in several pathways and played different roles in them. We selected most pathways Msr1 participated on our site, such as Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Msr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeCTSSA;BLB1;ITGA2;ATP6V0B;SEC61A1;MRC1;MHC2DCB;ATP6AP1B;ITGB3B

Msr1 has several biochemical functions, for example, low-density lipoprotein particle binding, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Msr1 itself. We selected most functions Msr1 had, and list some proteins which have the same functions with Msr1. You can find most of the proteins on our site.

Function Related Protein
low-density lipoprotein particle bindingLIPC;CRP;SCARB1;COLEC12;SORL1;PCSK9;THBS1;CDH13;MSR1
protein bindingC9orf9;TMEM19;S1PR3;MICU1;RAB2B;HSPG2;ERCC2;KRTAP4-11;TRIM25
scavenger receptor activityENDOU;MARCO;LGALS3BPA;SCARF1;PRSS12;ABHD1;TMPRSS4A;GM106;ACKR4

Msr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Msr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Msr1.

ATP6V0C; MALL; NKG7; LEPROTL1; SEC22A; HOOK3; Hook3

  • Q&As
  • Reviews

Q&As (5)

Ask a question
What is the primary function of the MSR1 protein, and in which cellular processes does it play a crucial role? 09/24/2020

MSR1 (Macrophage Scavenger Receptor 1) is involved in the recognition and clearance of modified low-density lipoproteins (LDL) by macrophages, playing a critical role in lipid homeostasis.

How does MSR1 contribute to the resolution of inflammation, and what mechanisms are involved in its anti-inflammatory effects? 02/10/2020

MSR1 contributes to the resolution of inflammation by promoting the clearance of apoptotic cells and debris. Its anti-inflammatory effects involve modulating cytokine production and signaling.

What role does MSR1 play in antigen presentation and T-cell activation within the immune system? 06/21/2019

MSR1 participates in antigen presentation by macrophages, influencing T-cell activation. This role connects MSR1 to adaptive immune responses.

What is the relationship between MSR1 and the clearance of amyloid-beta peptides, and how does this link to neurodegenerative diseases? 10/13/2018

MSR1 is involved in the clearance of amyloid-beta peptides associated with neurodegenerative diseases such as Alzheimer's. Its role in phagocytosis and clearance is crucial in the context of neuroinflammation.

How does MSR1 contribute to the immune response, and what are its implications in the context of inflammation and atherosclerosis? 01/31/2018

MSR1 modulates the immune response by regulating inflammatory signaling pathways. Its involvement in recognizing modified LDL in atherosclerotic plaques links it to inflammation and atherosclerosis.

Customer Reviews (3)

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Reviews
03/19/2022

    No more worries about protein sourcing. This product is a lifesaver in the lab.

    07/03/2020

      Outstanding service! Quick response to inquiries and prompt shipping. A+

      10/26/2019

        This is a must-have in any lab. Consistent quality and great results every time.

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