Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

MYC

  • Official Full Name

    v-myc avian myelocytomatosis viral oncogene homolog

  • Overview

    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitts lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    MYC; v-myc avian myelocytomatosis viral oncogene homolog; MRTL; MYCC; c-Myc; bHLHe39; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • 11R Tag
  • Arg
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYC-1028H Active Recombinant Human MYC Sf9 Insect Cell N/A
Human MYC-2522H Active Recombinant Human MYC, His-tagged E.coli His
Human MYC-79H Active Recombinant Human MYC protein, arginine-tagged E.coli Arg
Human MYC-26H Recombinant Human MYC protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MYC-39H Recombinant Human MYC, Arg-tagged E.coli Arg
Human MYC-152H Recombinant Human MYC tag protein E.coli N/A
Human MYC-254H Recombinant Human MYC protein, T7/His-tagged E.coli T7/His
Human MYC-1029H Recombinant Human MYC, His-tagged E.coli His
Human MYC-3627H Recombinant Human MYC protein, 11R-tagged E.coli 11R Tag
Human MYC-38H Recombinant Human MYC, His-tagged E.coli His
Human MYC-574H Recombinant Human MYC protein, His & GST-tagged E.coli His/GST Ser184~Ala454
Human MYC-4039HCL Recombinant Human MYC 293 Cell Lysate HEK293 N/A
Human MYC-5787H Recombinant Human MYC Protein, GST-tagged Wheat Germ GST
Human MYC-060H Recombinant Human MYC Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human MYC-3258H Recombinant Human MYC protein, His-GST-tagged E.coli His/GST 169-439aa
Human MYC-3257H Recombinant Human MYC protein, His-tagged E.coli His 1-439aa
Human MYC-1461H Recombinant Human MYC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MYC-4930HFL Recombinant Full Length Human MYC protein, Flag-tagged Mamanlian cells Flag
Human MYC-4637H Recombinant Human MYC Protein (351-437), His tagged E.coli His 351-437
Human MYC-757HFL Active Recombinant Full Length Human MYC Protein, C-Flag-tagged Mammalian cells Flag
Human MYC-4638H Recombinant Human MYC Protein (Glu351-Ser437), N-His tagged E.coli N-His Glu351-Ser437
Human MYC-6727HF Recombinant Full Length Human MYC Protein, GST-tagged In Vitro Cell Free System GST 439 amino acids
Human MYC-4639H Recombinant Human MYC Protein (Glu351-Ser437), N-GST tagged E.coli N-GST Glu351-Ser437
Human MYC-1461H-B Recombinant Human MYC Protein Pre-coupled Magnetic Beads HEK293
Human MYC-32H Recombinant Active Human c-Myc Protein (1-454) E.coli 1-454
Human MYC-3317H Recombinant Human MYC protein, His-tagged E.coli His Ser184~Ala454
Mouse Myc-6774M Recombinant Mouse Myc protein, His & GST-tagged E.coli His/GST Ala186~Ala439 (Accession # P01108)
Mouse Myc-71M Recombinant Mouse Myc, Arg-tagged E.coli Arg
Mouse Myc-4239M Recombinant Mouse Myc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Myc-3259M Recombinant Mouse Myc protein, GST-tagged E.coli GST 1-439aa
Rat MYC-3839R Recombinant Rat MYC Protein Mammalian Cell His
Rat MYC-3498R Recombinant Rat MYC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MYC-3498R-B Recombinant Rat MYC Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MYC-2916R Recombinant Rhesus monkey MYC Protein, His-tagged Mammalian Cell His
Rhesus Macaque MYC-2735R-B Recombinant Rhesus Macaque MYC Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MYC-2735R Recombinant Rhesus Macaque MYC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken MYC-2641C Recombinant Chicken MYC Mammalian Cell His
Kit-1785 Myc Reporter Kit (Myc Signaling Pathway) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MYC Related Articles
  • MYC Related Research Area
  • MYC Related Signal Pathway

MYC involved in several pathways and played different roles in them. We selected most pathways MYC participated on our site, such as Acute myeloid leukemia, Apoptosis, Binding of TCF/LEF:CTNNB1 to target gene promoters, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acute myeloid leukemiaRUNX1T1;STAT3;SFPI1;PIK3CA;KIT;PIK3CB;MAP2K1;BRAF;STAT5B
ApoptosisBAXB;CDK5RAP2;BCL2;BIRC3;IL1A;CASP6;PRKACA;NFKB1;RIPK1
Binding of TCF/LEF:CTNNB1 to target gene promoters
Bladder cancerRPS6KA5;IL-8;MMP2;CDK4;CXCL8;MMP1;E2F2;TYMP;MAPK1
C-MYB transcription factor networkPTCRA;GATA1;YEATS4;MYB;SKI;ADORA2B;CSF1R;ADA;CLTA
C-MYC pathwayKAT5;ACTL6A;HBP1;MYC;RUVBL2
CD40/CD40L signalingMYC;TDP2;JAK3
Cell CycleRBBP4;H3F3D;TGFB1A;KIF2B;YWHAZ;ZBTB17;TUBGCP5;LIN54;MAU2

MYC has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYC itself. We selected most functions MYC had, and list some proteins which have the same functions with MYC. You can find most of the proteins on our site.

Function Related Protein
DNA bindingJUNB;FOXI3B;TOPORS;ZNF572;PNX;BRPF1;KCNH7;TCEANC2;DNAJC2
E-box bindingLMO2;AHR;TCF3;NEUROD1;MYOD1;MYC;ASCL2;TWIST1;ZEB1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNDN;RFX4;MED1;ZNF92;CREB1;TBX3;MYF5;NEUROG3;PAXBP1
protein bindingKAT7;MON1B;RGS2;TIE1;MYBBP1A;Fert2;TUFM;TCTN2;DCUN1D5
protein complex bindingCPD;NDUFA4;RAP1A;IGBP1;STRN;FBN1;PTPRF;RIPK3;SHANK1
protein dimerization activityTFE3A;TFAP2A;NEUROG1;HER11;MESPAA;ARNTL1A;GRIN2A;TWIST1B;TCF3B
repressing transcription factor bindingHDAC4;CTBP1;RELA;ARNTL;CTNNB1;NOC2L;NFYB;HDAC7A;MAGEA2B
transcription factor activity, sequence-specific DNA bindingPOU3F3;STAT1B;CRX;AATF;ZNF193;NKX3-1;HOXB3;ZFP1;RBPJL
transcription factor bindingPIAS1;UBA2;KDM1A;PURB;TRAPPC2;MED6;TAF12;PPP1R13BB;THRA
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingFOSB;CREB3L2;HOXD13;TFAP4;KLF4;HIF1A;NEUROD1;KLF5;NUCKS1

MYC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYC here. Most of them are supplied by our site. Hope this information will be useful for your research of MYC.

MAX

Raha, Paromita; Thomas, Scott; et al. Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen resistant breast cancer models, by reversing Bcl-2 overexpression.. Breast cancer research : BCR 17:533-533(2015).
Li, Dan; Mei, Hong; et al. Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2.. Molecular cancer 14:320-320(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How does overexpression of the MYC gene affect cardiovascular disease? 11/14/2022

Abnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.

Is the MYC gene a potential target for pancreatic cancer or drug therapy? 06/18/2022

Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.

How does the MYC gene regulate somatic cell proliferation through cell cycle progression? 05/13/2021

The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.

What is the role of the MYC gene in stomach cancer? 03/20/2021

Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.

Is the MYC gene associated with hematopoietic stem cells? 07/10/2020

MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.

How does abnormal expression of the MYC gene affect tumor progression? 10/30/2019

Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.

Customer Reviews (3)

Write a review
Reviews
05/19/2022

    The reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.

    01/18/2020

      Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.

      10/06/2019

        Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.

        Ask a Question for All MYC Products

        Required fields are marked with *

        My Review for All MYC Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends