MYC
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Official Full Name
v-myc avian myelocytomatosis viral oncogene homolog
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Overview
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitts lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] -
Synonyms
MYC; v-myc avian myelocytomatosis viral oncogene homolog; MRTL; MYCC; c-Myc; bHLHe39; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- 11R Tag
- Arg
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc|DDK
- N/A
- N
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- MYC Related Articles
- MYC Related Research Area
- MYC Related Signal Pathway
MYC involved in several pathways and played different roles in them. We selected most pathways MYC participated on our site, such as Acute myeloid leukemia, Apoptosis, Binding of TCF/LEF:CTNNB1 to target gene promoters, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Acute myeloid leukemia | RUNX1T1;STAT3;SFPI1;PIK3CA;KIT;PIK3CB;MAP2K1;BRAF;STAT5B |
Apoptosis | BAXB;CDK5RAP2;BCL2;BIRC3;IL1A;CASP6;PRKACA;NFKB1;RIPK1 |
Binding of TCF/LEF:CTNNB1 to target gene promoters | |
Bladder cancer | RPS6KA5;IL-8;MMP2;CDK4;CXCL8;MMP1;E2F2;TYMP;MAPK1 |
C-MYB transcription factor network | PTCRA;GATA1;YEATS4;MYB;SKI;ADORA2B;CSF1R;ADA;CLTA |
C-MYC pathway | KAT5;ACTL6A;HBP1;MYC;RUVBL2 |
CD40/CD40L signaling | MYC;TDP2;JAK3 |
Cell Cycle | RBBP4;H3F3D;TGFB1A;KIF2B;YWHAZ;ZBTB17;TUBGCP5;LIN54;MAU2 |
MYC has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYC itself. We selected most functions MYC had, and list some proteins which have the same functions with MYC. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | JUNB;FOXI3B;TOPORS;ZNF572;PNX;BRPF1;KCNH7;TCEANC2;DNAJC2 |
E-box binding | LMO2;AHR;TCF3;NEUROD1;MYOD1;MYC;ASCL2;TWIST1;ZEB1 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | NDN;RFX4;MED1;ZNF92;CREB1;TBX3;MYF5;NEUROG3;PAXBP1 |
protein binding | KAT7;MON1B;RGS2;TIE1;MYBBP1A;Fert2;TUFM;TCTN2;DCUN1D5 |
protein complex binding | CPD;NDUFA4;RAP1A;IGBP1;STRN;FBN1;PTPRF;RIPK3;SHANK1 |
protein dimerization activity | TFE3A;TFAP2A;NEUROG1;HER11;MESPAA;ARNTL1A;GRIN2A;TWIST1B;TCF3B |
repressing transcription factor binding | HDAC4;CTBP1;RELA;ARNTL;CTNNB1;NOC2L;NFYB;HDAC7A;MAGEA2B |
transcription factor activity, sequence-specific DNA binding | POU3F3;STAT1B;CRX;AATF;ZNF193;NKX3-1;HOXB3;ZFP1;RBPJL |
transcription factor binding | PIAS1;UBA2;KDM1A;PURB;TRAPPC2;MED6;TAF12;PPP1R13BB;THRA |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOSB;CREB3L2;HOXD13;TFAP4;KLF4;HIF1A;NEUROD1;KLF5;NUCKS1 |
MYC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYC here. Most of them are supplied by our site. Hope this information will be useful for your research of MYC.
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- Q&As
- Reviews
Q&As (6)
Ask a questionAbnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.
Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.
The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.
Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.
MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.
Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.
Customer Reviews (3)
Write a reviewThe reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.
Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.
Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.
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