MYLK
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Official Full Name
myosin light chain kinase
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Overview
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3 region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. -
Synonyms
MYLK; myosin light chain kinase; myosin, light polypeptide kinase; myosin light chain kinase, smooth muscle; MLCK; MLCK1; MYLK1; smMLCK; smooth muscle myosin light chain kinase; telokin; kinase-related protein; KRP; AAT7; MLCK108; MLCK210; MSTP083; FLJ122;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His|GST
- His|T7
- SUMO
- Myc
- DDK
- MYC
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | MYLK-1509H | Recombinant Human MYLK protein, His & GST-tagged | E.coli | His/GST | Phe1661~Asp1877 (Accession # Q15746) | |
Human | MYLK-696H | Recombinant Human Myosin Light Chain Kinase, GST-tagged | Insect Cell | GST | ||
Human | MYLK-27838TH | Recombinant Human MYLK | N/A | |||
Human | MYLK-355H | Recombinant Human Myosin Light Chain Kinase, GST-tagged, Active | Sf9 Insect Cell | GST | ||
Human | MYLK-4017HCL | Recombinant Human MYLK 293 Cell Lysate | HEK293 | N/A | ||
Human | MYLK-4858H | Recombinant Human MYLK Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | MYLK-5820H | Recombinant Human MYLK Protein, GST-tagged | Wheat Germ | GST | ||
Human | MYLK-5954H | Recombinant Human MYLK protein, His-tagged | E.coli | His | 1464-1719aa | |
Human | MYLK-6768HF | Recombinant Full Length Human MYLK Protein, GST-tagged | In Vitro Cell Free System | GST | 992 amino acids | |
Human | MYLK-4651H | Recombinant Human MYLK Protein (Thr1748-Glu1914), N-His tagged | E.coli | N-His | Thr1748-Glu1914 | |
Mouse | Mylk-1510M | Recombinant Mouse Mylk protein, His & T7-tagged | E.coli | His/T7 | Met1684~Asp1884 (Accession # Q6PDN3) | |
Mouse | Mylk-335M | Recombinant Mouse Mylk Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Chicken | MYLK-7009C | Recombinant Chicken MYLK | Mammalian Cell | His | ||
Chicken | Mylk-3878C | Recombinant Chicken Mylk protein, His-SUMO & Myc-tagged | E.coli | His-SUMO & Myc | 1435-1722aa |
- Involved Pathway
- Protein Function
- Interacting Protein
MYLK involved in several pathways and played different roles in them. We selected most pathways MYLK participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Calcium signaling pathway | CALML3;TRHR;CHRM3;F2R;ADCY2B;AGTR1;HTR2CL1;PLCD3A;SLC8A2B |
cGMP-PKG signaling pathway | NOS3;IRS2;ATP1A2;PPP3CA;VDAC3;ATP1B2;ATP1B3;LOC100328615;NPPB |
Vascular smooth muscle contraction | PPP1CB;PPP1R14AB;CALML5;GNA11B;MYL6;PRKCDA;CALD1;PRKCBB;PRKCD |
Focal adhesion | THBS3;PIK3CB;ACTN4;MET;RHOAC;ACTB;RAP1AA;TNK2;SRMS |
Platelet activation | GP1BB;PRKACA;VWF;GNAI1;PLA2G4A;FCER1G;GP9;GNAQ;ARHGEF12 |
Regulation of actin cytoskeleton | CHRM5A;CHRM2A;RAF1A;ITGA9;PIK3R3B;GNA13A;PIK3CD;MSN;ROCK2B |
Oxytocin signaling pathway | MYL6;ELK1;GUCY1B3;EEF2K;PRKAB1;PPP1CA;PLA2G4A;RHOA;CACNA2D2 |
Gastric acid secretion | Adcy4;SLC26A7;MYLK3;PLCB1;PLCB4;KCNJ2;MYLK;CAMK2B;ATP1A3 |
MYLK has several biochemical functions, for example, ATP binding, actin binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYLK itself. We selected most functions MYLK had, and list some proteins which have the same functions with MYLK. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | SARS;DCLK1;CHD1L;LCK;WARS;SGK2B;MAP2K7;ABCB3L1;PRPF4BB |
actin binding | LMOD1;PARVB;EZR;MYH1;DSTN;DMTN;Fert2;BAIAP2L1;PARVAB |
calmodulin binding | NDUFAF4;MYO5C;MYH1E;SRY;SPHK1;SNTA1;MAPKAPK2A;SLC8A2;TRPV6 |
metal ion binding | PLEKHF1;ZNF404;FTR67;SCD5;POLA1;ARSJ;CFI;SCRT2;ITGB2 |
myosin light chain kinase activity | MYLK;MYLK3;MYLK2 |
protein binding | RALGDS;LRRC29;ANGPT1;HRK;HMMR;ZFYVE20;SFRP4;F11;FCER1G |
MYLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYLK here. Most of them are supplied by our site. Hope this information will be useful for your research of MYLK.
GOPC; MYL12A; NCK1; PIK3R1; GRB2; CTTN; HSPB1; q7ard3_yerpe; q7cje7_yerpe; ahpC; exuR; tbpA1; q8d0g3_yerpe; npm_alk
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