Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

MYOM1

Official Full Name

myomesin 1, 185kDa
Overview

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

MYOM1; myomesin 1, 185kDa; myomesin 1 (skelemin) (185kD) , myomesin 1 (skelemin) 185kDa; myomesin-1; skelemin; EH-myomesin; myomesin family member 1; myomesin 1 (skelemin) 185kDa; myomesin (M-protein) 1 (190kD); 190 kDa titin-associated protein; 190 kDa;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MYOM1-1148H	Recombinant Human MYOM1, GST-tagged	E.coli	GST	C-360aa	$319 / 25ug
Human	MYOM1-5854H	Recombinant Human MYOM1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	MYOM1-10352M	Recombinant Mouse MYOM1 Protein	Mammalian Cell	His		Inquiry
Mouse	MYOM1-5868M	Recombinant Mouse MYOM1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MYOM1-5868M-B	Recombinant Mouse MYOM1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	MYOM1-6518C	Recombinant Chicken MYOM1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MYOM1 Related Articles

MYOM1 involved in several pathways and played different roles in them. We selected most pathways MYOM1 participated on our site, such as Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYOM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Striated Muscle Contraction	TNNI2A.4;TNNI2;TCAP;TNNI1B;TNNT3A;ACTA1B;TNNT3;MYOM1;MYLZ3

MYOM1 has several biochemical functions, for example, identical protein binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYOM1 itself. We selected most functions MYOM1 had, and list some proteins which have the same functions with MYOM1. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	IL12B;TK1;PRMT1;PICK1;ACTG1;C1S;TRAF2;RILPL2;CBLL1
protein binding	KCNB1;SPHK2;VPS8;C4orf46;MED24;STX16;PFN1;GFAP;TAF7L
protein homodimerization activity	NRBP1;NKX2;P2RX4;QPRT;CSF1;TESCA;LGALS6;CACYBP;TYR
structural constituent of muscle	SORBS2;ANKRD2;TPM1;MYOT;MYL6B;MYBPC1;MYL1;ASPH;ACTN3

MYOM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYOM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYOM1.

DYSF; ANKRD28; DNAJB6; C1QTNF9; SYNE1; TTN

O'Brien, AMP; Utsunomiya, YT; et al. Assessing signatures of selection through variation in linkage disequilibrium between taurine and indicine cattle. GENETICS SELECTION EVOLUTION 46:-(2014).

Occella, C; Bleidl, D; et al. Identification of an Interstitial 18p11.32-p11.31 Duplication Including the EMILIN2 Gene in a Family with Porokeratosis of Mibelli. PLOS ONE 8:-(2013).