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NAPRT1

Official Full Name

nicotinate phosphoribosyltransferase domain containing 1
Overview

Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).
Synonyms

NAPRT1; nicotinate phosphoribosyltransferase domain containing 1; nicotinate phosphoribosyltransferase; PP3856; FHIP; FHA HIT interacting protein; NAPRTase; Nicotinic acid phosphoribosyltransferase; FHA-HIT-interacting protein; nicotinate phosphoribosyltransferase domain-containing protein 1;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell
Yeast

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NAPRT1-1165HCL	Recombinant Human NAPRT1 cell lysate		N/A		Inquiry
Human	NAPRT1-677H	Recombinant Human NAPRT1 Protein (229-538 aa), GST-tagged	E.coli	GST	229-538 aa	Inquiry
Human	NAPRT1-5476H	Recombinant Human NAPRT1 protein, His-tagged	Yeast	His	229-538aa	Inquiry
Mouse	NAPRT1-10426M	Recombinant Mouse NAPRT1 Protein	Mammalian Cell	His		Inquiry
Mouse	NAPRT1-5908M-B	Recombinant Mouse NAPRT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	NAPRT1-5908M	Recombinant Mouse NAPRT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NAPRT1-3902R	Recombinant Rat NAPRT1 Protein	Mammalian Cell	His		Inquiry
Rat	NAPRT1-3561R	Recombinant Rat NAPRT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NAPRT1-3561R-B	Recombinant Rat NAPRT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	NAPRT1-7104C	Recombinant Chicken NAPRT1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NAPRT1 involved in several pathways and played different roles in them. We selected most pathways NAPRT1 participated on our site, such as Nicotinate and nicotinamide metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAPRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Nicotinate and nicotinamide metabolism	NADSYN1;NT5C2B;MIBP2;NUDT12;ENPP3;CD38;ENPP1;KCNG4;PNP5A
Metabolic pathways	CYCS;PTDSS1A;FUT9;ALDH1A1;ALG6;UGT1A6;COX6B1;MAT2A;QRSL1

NAPRT1 has several biochemical functions, for example, ligase activity, nicotinate phosphoribosyltransferase activity, nicotinate-nucleotide diphosphorylase (carboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAPRT1 itself. We selected most functions NAPRT1 had, and list some proteins which have the same functions with NAPRT1. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	TRAF6;RLIM;RNF19B;PELI1;UBE4B;RNF144B;MARCH4;GLULC;RNF25
nicotinate phosphoribosyltransferase activity	NAPRT;NAPRT1;KCNG4
nicotinate-nucleotide diphosphorylase (carboxylating) activity	NAMPT;NAPRT1;QPRT;NAMPTB;NAPRT;KCNG4
protein binding	TIMP1;SELP;BCL2L15;LNX1;TAGLN;RALY;PRICKLE1A;JAM2A;AKAP13

NAPRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAPRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAPRT1.

RBPMS; GRAMD3; IGBP1