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NAT8L

  • Official Full Name

    N-acetyltransferase 8-like (GCN5-related, putative)

  • Overview

    This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia).
  • Synonyms

    NAT8L; N-acetyltransferase 8-like (GCN5-related, putative); N acetyltransferase 8 like; N-acetylaspartate synthetase; FLJ37478; Hcml3; CML3; N acetyltransferase 8 like (GCN5 related, putative); NAT8 like; NAA synthetase; camello-like protein 3; NACED; NAT8-LIKE;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NAT8L-4994H Recombinant Human NAT8L protein, His-tagged E.coli His
Human NAT8L-4954H Recombinant Human NAT8L protein, GST-tagged Wheat Germ GST
Human NAT8L-3960HCL Recombinant Human NAT8L 293 Cell Lysate HEK293 N/A
Human NAT8L-739HF Recombinant Full Length Human NAT8L Protein, GST-tagged In Vitro Cell Free System GST 134 amino acids
Mouse NAT8L-10441M Recombinant Mouse NAT8L Protein Mammalian Cell His
Mouse NAT8L-5921M-B Recombinant Mouse NAT8L Protein Pre-coupled Magnetic Beads HEK293
Mouse NAT8L-5921M Recombinant Mouse NAT8L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NAT8L-3910R Recombinant Rat NAT8L Protein Mammalian Cell His
Rat NAT8L-3569R Recombinant Rat NAT8L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NAT8L-3569R-B Recombinant Rat NAT8L Protein Pre-coupled Magnetic Beads HEK293
Danio rerio (Zebrafish) (Brachydanio rerio) RFL25461DF Recombinant Full Length Danio Rerio N-Acetylaspartate Synthetase(Nat8L) Protein, His-Tagged E.coli expression system His Full Length (1-282)
Homo sapiens (Human) RFL27543HF Recombinant Full Length Human N-Acetylaspartate Synthetase(Nat8L) Protein, His-Tagged E.coli expression system His Full Length (1-302)
Mus musculus (Mouse) RFL3493MF Recombinant Full Length Mouse N-Acetylaspartate Synthetase(Nat8L) Protein, His-Tagged E.coli expression system His Full Length (1-299)
Rattus norvegicus (Rat) RFL2163RF Recombinant Full Length Rat N-Acetylaspartate Synthetase(Nat8L) Protein, His-Tagged E.coli expression system His Full Length (1-299)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL3183XF Recombinant Full Length Xenopus Tropicalis N-Acetylaspartate Synthetase(Nat8L) Protein, His-Tagged E.coli expression system His Full Length (1-271)
Zebrafish NAT8L-5455Z Recombinant Zebrafish NAT8L Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NAT8L Related Articles

NAT8L involved in several pathways and played different roles in them. We selected most pathways NAT8L participated on our site, such as Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT8L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alanine, aspartate and glutamate metabolismGPT2;GLULA;NAT8L;GLUD2;CPS1;GLUD1A;DDO;GLULC;ABAT
Metabolic pathwaysMGAT3A;udp;FTCD;CHIA.2;ACAD8;MTMR7B;PIGW;BCO1L;CYP2C55

NAT8L has several biochemical functions, for example, aspartate N-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT8L itself. We selected most functions NAT8L had, and list some proteins which have the same functions with NAT8L. You can find most of the proteins on our site.

Function Related Protein
aspartate N-acetyltransferase activity

NAT8L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT8L here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT8L.

Nitta, A; Iegaki, N; et al. N-Acetyltransferase Shati/Nat8l in the Dorsal Striatum Regulates Sociability and Motivation via Control of the Serotonergic Neuronal System in Mice. NEUROPSYCHOPHARMACOLOGY 39:S534-S535(2014).
Uno, K; Miyamoto, Y; et al. SHATI/NAT8L REGULATES DOPAMINE RELEASE-INDUCED BY NICOTINE IN NUCLEUS ACCUMBENS. ALCOHOL AND ALCOHOLISM 49:-(2014).
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