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NCF4

  • Official Full Name

    neutrophil cytosolic factor 4, 40kDa

  • Overview

    The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms

    NCF4; neutrophil cytosolic factor 4, 40kDa; neutrophil cytosolic factor 4 (40kD); neutrophil cytosol factor 4; neutrophil NADPH oxidase factor 4; p40phox; SH3PXD4; NCF-4; p40-phox; SH3 and PX domain-containing protein 4; NCF; MGC3810;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • C
  • Myc
  • DDK
  • His
  • His (Fc)
  • Avi
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NCF4-7201H Recombinant Human Neutrophil Cytosolic Factor 4, 40kDa, His-tagged E.coli His 1-339aa
Human NCF4-1210H Recombinant Human NCF4, His-tagged E.coli His 1-348aa
Human NCF4-29348TH Recombinant Human NCF4 N/A
Human NCF4-519H Recombinant Human NCF4 Mammalian Cell His
Human NCF4-2953H Recombinant Human Neutrophil Cytosolic Factor 4, 40kDa, T7-tagged E.coli T7
Human NCF4-465H Recombinant Human NCF4 Protein, His-tagged E.coli His Phe132~Pro339
Human NCF4-3948HCL Recombinant Human NCF4 293 Cell Lysate HEK293 N/A
Human NCF4-3949HCL Recombinant Human NCF4 293 Cell Lysate HEK293 N/A
Human NCF4-180H Recombinant Human NCF4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human NCF4-3592H Recombinant Human NCF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NCF4-3592H-B Recombinant Human NCF4 Protein Pre-coupled Magnetic Beads HEK293
Mouse NCF4-10469M Recombinant Mouse NCF4 Protein Mammalian Cell His
Mouse Ncf4-466M Recombinant Mouse Ncf4 Protein, His-tagged E.coli His Ala111~Pro339
Mouse Ncf4-4310M Recombinant Mouse Ncf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NCF4-5939M Recombinant Mouse NCF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NCF4-5939M-B Recombinant Mouse NCF4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NCF4-11732Z Recombinant Zebrafish NCF4 Mammalian Cell His
Chicken NCF4-3336C Recombinant Chicken NCF4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NCF4 involved in several pathways and played different roles in them. We selected most pathways NCF4 participated on our site, such as Phagosome, Osteoclast differentiation, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeATP6V1D;MHC1UEA;ATP6V1BA;STX7;Cd209g;MHC2A;TUBA1L;TUBA8L2;CLEC4M
Osteoclast differentiationPPP3CC;FCGR2C;SPI1;MAPK10;CAMK4;TNFRSF1A;TREM2;IL1R1;MAPK8
Leukocyte transendothelial migrationMAPK12;GNAI2;PTK2B;RHOA;BCAR1;MYL5;CLDN22;JAM2;PRKCA
LeishmaniasisIFNG;IFNGR2;IRAK4;HLA-DPB1;HLA-DRB3;NCF2;ITGB1;ITGB2;MAPK11

NCF4 has several biochemical functions, for example, phosphatidylinositol-3-phosphate binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCF4 itself. We selected most functions NCF4 had, and list some proteins which have the same functions with NCF4. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol-3-phosphate bindingSNX20;RS1;SH3PXD2B;ZFYVE19;PLEKHF1;WIPI1;ZFYVE26;PHLDA3;BBS5
protein bindingRXRA;CACYBP;RAN;RANGAP1;SCNM1;BMP1A;CLC;C1S;OTULIN
protein dimerization activityPPP3CB;HER8A;NEUROD6A;HER4.3;ARNTL1A;POLR1D;POLR1C;HES6;ID2
superoxide-generating NADPH oxidase activator activityPDGFB;NOXO1;AGT;NOXA1;NCF4

NCF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCF4.

NCF2; NCF1; CYBA; MLH1; gatA

  • Q&As
  • Reviews

Q&As (5)

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How does NCF4 protein interact with other components of the NADPH oxidase complex? 12/02/2022

NCF4 protein interacts with other subunits of the NADPH oxidase complex, such as p22phox, p47phox, and p67phox, to assemble the active enzyme complex for ROS production.

What are the implications of NCF4 protein dysfunction in the context of cancer? 05/14/2022

Dysregulation of NCF4 protein function may impact the immune response to cancer cells and potentially influence the tumor microenvironment, with potential implications for cancer progression and immunotherapy.

What are the potential therapeutic implications of targeting NCF4 protein? 06/11/2020

Targeting NCF4 protein may offer new therapeutic strategies for the treatment of immune disorders and inflammatory conditions by modulating ROS production and immune cell function.

How can NCF4 protein be measured in clinical settings? 04/22/2020

NCF4 protein levels can be measured using techniques such as western blotting, ELISA, or flow cytometry in clinical research and diagnostic laboratories.

Can variations in the NCF4 gene affect individual susceptibility to infections? 01/12/2016

Genetic variations in the NCF4 gene may influence an individual's susceptibility to infections by impacting the efficiency of phagocyte-mediated killing of pathogens.

Customer Reviews (3)

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Reviews
01/27/2020

    Researchers can confidently incorporate NCF4 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.

    07/11/2018

      the NCF4 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.

      05/16/2018

        The manufacturer of NCF4 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.

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