NCKIPSD
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Official Full Name
NCK interacting protein with SH3 domain
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Overview
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified. -
Synonyms
NCKIPSD; NCK interacting protein with SH3 domain; NCK-interacting protein with SH3 domain; AF3P21; dia interacting protein; diaphanous protein interacting protein; DIP1; ORF1; SH3 protein interacting with Nck; 90 kDa; SPIN90; WASLBP; WISH; DIP; SH3 protein interacting with Nck90 kDa; VIP54; DIP-1; OTTHUMP00000164823; OTTHUMP00000210186; dia-interacting protein 1; SH3 adapter protein SPIN90; 54 kDa VacA-interacting protein; 54 kDa vimentin-interacting protein; WASP-interacting SH3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Fc|His
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NCKIPSD involved in several pathways and played different roles in them. We selected most pathways NCKIPSD participated on our site, such as Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCKIPSD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fcgamma receptor (FCGR) dependent phagocytosis | DOCK1;NCKAP1;NCKIPSD;WASF2;ARPC1A;WIPF3;PPAPDC1A;ABI2;ABI1B |
| Immune System | SRMS;TRIM45;RNF34;LAIR2;CMTM2A;IL1RN;MGC174152;TRIM68;ACTR2B |
| Innate Immune System | TNIP2;PPAPDC1A;BTR06;PELI2;CTSLL;CLEC5A;ACTR2B;GZMM;PELI1 |
| RHO GTPase Effectors | ABI1B;NSL1;EVL;WIPF2;NDEL1B;ZWINT;KTN1;NCKIPSD;PMF1 |
| RHO GTPases Activate WASPs and WAVEs | WIPF3;WASF3;WIPF2;NCKIPSD;ABI1B;ABI2;ABI1A |
| Regulation of actin dynamics for phagocytic cup formation | ABI1B;WIPF3;ABI1A;NCKIPSD;MYO1C;WIPF2;MYO9B |
| Signal Transduction | SHARPIN;RHOT1A;OXTRL;PROK1;EMR2;QRFPR;IFT88;PLEKHG2;OPN1LW2 |
| Signaling by Rho GTPases | ARHGAP6;ARHGEF16;NOXO1A;FMNL2;MKL1B;ARHGAP17B;ARAP2;TAX1BP3;ARHGAP1 |
NCKIPSD has several biochemical functions, for example, SH3 domain binding, cytoskeletal protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCKIPSD itself. We selected most functions NCKIPSD had, and list some proteins which have the same functions with NCKIPSD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | CRB3;SH3BGRL2;PLSCR3;CABYR;ENKUR;CD3E;PLSCR4;DPYSL3;MVB12A |
| cytoskeletal protein binding | ALDOB;PKD2;PACSIN2;PACSIN3;MSNA;ABI1;EZRB;ALDOC;PTPN4B |
| protein binding | ODF2;ANO6;RBM12B;IL15RA;DPEP3;HACE1;TAGLN;FAM129A;SNAI2 |
NCKIPSD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCKIPSD here. Most of them are supplied by our site. Hope this information will be useful for your research of NCKIPSD.
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