nde1
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  • Official Full Name
  • nudE nuclear distribution gene E homolog 1 (A. nidulans)
  • Background
  • This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • NDE1; nudE nuclear distribution gene E homolog 1 (A. nidulans); nuclear distribution protein nudE homolog 1; FLJ20101; NUDE; HOM TES 87; LIS1 interacting protein NUDE1rat homolog; LIS1 interacting protein NUDE1; NDE 1; NDE1_HUMAN; Nuclear distribution gene E homolog 1; NUDE 1; NudE nuclear distribution gene E homolog 1; NUDE1; OTTHUMP00000160329; OTTHUMP00000160330; LIS1-interacting protein NUDE1, rat homolog; LIS4; HOM-TES-87
Cat.#:NDE1-1218HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDE1, GST-tagged
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Cat.#:NDE1-28795THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDE1, His-tagged
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Cat.#:NDE1-3514HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDE1, His-tagged
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Cat.#:NDE1-10494MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDE1 Protein
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Cat.#:NDE1-3926RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NDE1 Protein
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Cat.#:NDE1-2964RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NDE1 Protein, His-tagged
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Cat.#:NDE1-1319CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NDE1
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Cat.#:NDE1-3303ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDE1
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Cat.#:NDE1-3938HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDE1 293 Cell Lysate
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Involved Pathway

NDE1 involved in several pathways and played different roles in them. We selected most pathways NDE1 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDE1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Anchoring of the basal body to the plasma membrane
CLASP1; BBS13; CEP78; DCTN1A; CSNK1D; SDCCAG8; NINL; ODF2B; B9D1; DYNC1I2
Assembly of the primary cilium
TCP1; AKAP9; RHOL; RAB3IP; FBF1; CLASP1A; ARF4A; LZTFL1; ARF4; IFT81
Cell Cycle
ANAPC7; TGFB1A; DKC1; HTATIP; POLD3; STIL; NCAPG2; CENPK; E2F2; RBX1
Cell Cycle, Mitotic
NSL1; CEP70; SET; LIN52; CDK6; GINS1; CEP76; SPDL1; PDS5B; H3F3B.1
Centrosome maturation
FGFR1OP; TUBGCP5; SSNA1; CSNK1D; MAPRE1A; CEP70; ACTR1A; CEP57; CLASP1A; MAPRE1
G2/M Transition
LIN37; BORA; CEP135; NDE1; DCTN3; FOXM1; MAPRE1A; ODF2; TUBGCP2; ACTR1A
Loss of Nlp from mitotic centrosomes
TSGA14; CEP63; CCP110; NEDD1; CEP152; SDCCAG8; PLK4; CEP57; CENPJ; CLASP1A
Loss of proteins required for interphase microtubule organizationfrom the centrosome
CEP63; SSNA1; DCTN1A; TUBG1; MAPRE1A; CCP110; TSGA14; PCM1; NINL; MAPRE1B

Protein Function

NDE1 has several biochemical functions, for example, identical protein binding, microtubule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDE1 itself. We selected most functions NDE1 had, and list some proteins which have the same functions with NDE1. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein MLL1; LYZ1; PPP5C; RUVBL2; DVL1; KHDRBS1; AMELX; PRDX1; NCAM1; DAPK1
Function microtubule binding
Related Protein MAP1LC3C; GABARAP; TPPP; EML2; JAKMIP2; CHD4; KIF23; HAUS8; GOLSYN; JAKMIP3
Function protein binding
Related Protein CCND1; C11orf46; HTR6; HDAC6; PTRH2; TNFRSF21; TPI1; H3F3B; CDC23; CDKN1A
Function protein domain specific binding
Related Protein IPCEF1; Akap2; VPS11; NFASC; TWIST2; HIST1H4L; STRN4; ATP1A1; YWHAB; IGBP1

Interacting Protein

NDE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDE1.
Pafah1b1; ZNF365; CDK1; CENPF; Nde1; q81ks6_bacan; Ccser2; AMZ2; APIP; LCOR; CLPTM1L; DCAF13

NDE1 Related Articles

Lee, JY; Kang, CD; et al. Engineering Cellular Redox Balance in Saccharomyces cerevisiae for Improved Production of L-Lactic Acid. BIOTECHNOLOGY AND BIOENGINEERING 112:751-758(2015).
Okamoto, M; Iguchi, T; et al. DBZ Regulates Cortical Cell Positioning and Neurite Development by Sustaining the Anterograde Transport of Lis1 and DISC1 through Control of Ndel1 Dual-Phosphorylation. JOURNAL OF NEUROSCIENCE 35:2942-2958(2015).