NDEL1
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Official Full Name
nudE nuclear distribution E homolog (A. nidulans)-like 1
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Overview
This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
NDEL1; nudE nuclear distribution E homolog (A. nidulans)-like 1; nudE nuclear distribution gene E homolog (A. nidulans) like 1; nuclear distribution protein nudE-like 1; MITAP1; NUDEL; protein Nudel; endooligopeptidase A; mitosin-associated protein 1; mit;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NDEL1 involved in several pathways and played different roles in them. We selected most pathways NDEL1 participated on our site, such as Aurora A signaling, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDEL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aurora A signaling | AURKAIP1;TPX2;TACC3;TACC1;OAZ1;TDRD7;CENPA;NDEL1;AURKB |
| Cell Cycle | CDK11B;PCM1;CDCA5;CHEK2;CEP164;SKA1;MSH5;NIPBL;MDM2 |
| Cell Cycle, Mitotic | CEP72;H3F3D;CDKN1B;CDT1;MAU2;KIF2A;FOXM1;CEP63;NIPBLB |
| Lissencephaly gene (LIS1) in neuronal migration and development | NUDC;MAP1B;DYNLT1;VLDLR;DCX;KATNA1;NDEL1;LRPAP1;DAB1 |
| M Phase | SMC4;NEK7;CENPC1;PMF1;GOLGA2;CENPQ;CLIP1;ENSA;GORASP1 |
| Mitotic Anaphase | NSL1;SPC24;SKA1;CENPL;KNTC1;PDS5A;DSN1;CENPK;B9D2 |
| Mitotic Metaphase and Anaphase | PDS5A;CENPC1;NSL1;WAPAL;CENPO;CENPI;VRK1;SKA1;TMPO |
| Mitotic Prometaphase | SKA2;NCAPH;CLIP1;SPC24;CENPO;RANGAP1B;NCAPG;SPC25;SGOL1 |
NDEL1 has several biochemical functions, for example, alpha-tubulin binding, beta-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDEL1 itself. We selected most functions NDEL1 had, and list some proteins which have the same functions with NDEL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-tubulin binding | PACRG;BBS4;WASH;OFD1;SNCA;ARL4C;INO80;FAM110C;NCALD |
| beta-tubulin binding | HDAC6;CASC1;GABARAPL2;EMD;MAP1S;ARL8B;ARL8A;GABARAPL1;SIRT2 |
| microtubule binding | KIF27;KIF5AA;CLIP3;RACGAP1;SERPINB1A;DPYSL5A;GABARAPL2;CAMSAP1A;NUMA1 |
| oligopeptidase activity | |
| protein binding | STK36;GRIN1;MYCBP2;CENPP;ZC3H10;HAPLN2;SYT16;CALU;MAX |
NDEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDEL1.
CENPF; DISC1; TRIM27
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