ndel1
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  • Official Full Name
  • nudE nuclear distribution E homolog (A. nidulans)-like 1
  • Background
  • This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms
  • NDEL1; nudE nuclear distribution E homolog (A. nidulans)-like 1; nudE nuclear distribution gene E homolog (A. nidulans) like 1; nuclear distribution protein nudE-like 1; MITAP1; NUDEL; protein Nudel; endooligopeptidase A; mitosin-associated protein 1; mit
Cat.#:NDEL1-10495MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDEL1 Protein
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Cat.#:NDEL1-3927RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NDEL1 Protein
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Cat.#:NDEL1-2399CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NDEL1
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Cat.#:NDEL1-3936HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDEL1 293 Cell Lysate
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Cat.#:NDEL1-3937HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDEL1 293 Cell Lysate
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Involved Pathway

NDEL1 involved in several pathways and played different roles in them. We selected most pathways NDEL1 participated on our site, such as Aurora A signaling, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDEL1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aurora A signaling
TPX2; NDEL1; TACC1; AURKB; AURKAIP1; TDRD7; GADD45A; TACC3; CENPA; OAZ1
Cell Cycle
RB1; ORC1L; RAD1; DCTN2; CCNA2; ESCO1; GADD45BA; NCAPD2; PDS5B; ANAPC5
Cell Cycle, Mitotic
SDCCAG8; SGOL1; DSN1; TUBG2; BANF1; CDCA8; NDEL1; HIST4H4; CKS1B; ODF2
Lissencephaly gene (LIS1) in neuronal migration and development
DCX; KATNA1; LRPAP1; NDEL1; DYNLT1; VLDLR; DAB1; NUDC; MAP1B
M Phase
CENPN; GORASP2; CENPK; ITGB3BP; CTDNEP1A; NDC80; SKA1; CDCA5; NDEL1; NCAPD2
Mitotic Anaphase
CENPI; CENPQ; KNTC1; CDCA5; INCENP; PDS5B; CENPE; LEMD3; NDEL1; NSL1
Mitotic Metaphase and Anaphase
PMF1; SGOL1; NSL1; MIS12; ANKLE2; NDEL1; ITGB3BP; CCDC99; LEMD3; INCENP
Mitotic Prometaphase
NCAPH; INCENP; NDEL1A; CCDC99; MIS12; CENPQ; ZWINT; SMC4; SKA2; SKA1

Protein Function

NDEL1 has several biochemical functions, for example, alpha-tubulin binding, beta-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDEL1 itself. We selected most functions NDEL1 had, and list some proteins which have the same functions with NDEL1. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-tubulin binding
Related Protein SLC6A2; INO80; FNTA; SPAST; FAM110C; WASH1; SERPINB1A; RACGAP1; NDEL1; CAV3
Function beta-tubulin binding
Related Protein OST4; HTT; PACRG; RANBP10; TBCD; CCT5; UXT; SERPINB1A; AKAP1; ARL8A
Function microtubule binding
Related Protein GABARAPL1; KIF3A; KIF4A; SGIP1; HDAC6; CEP57L1; GABARAPL2; CHP1; MARK4; PAFAH1B1B
Function oligopeptidase activity
Related Protein NDEL1
Function protein binding
Related Protein ETF1; ALS2CR11; ECE2; EPB41L1; POC5; BBS7; SLC30A8; EIF2S1; PPIE; SAMM50

Interacting Protein

NDEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDEL1.
CENPF; DISC1; TRIM27