ndufa8
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
  • Background
  • The protein encoded by this gene belongs to the complex I 19 kDA subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
  • Synonyms
  • NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 (19kD, PGIV); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; complex I PGIV subunit; MGC793; PGIV; complex I-19kD; c
Cat.#:NDUFA8-1226HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFA8, GST-tagged
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Cat.#:NDUFA8-129HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFA8 Protein, His-tagged
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Cat.#:NDUFA8-10522MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFA8 Protein
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Cat.#:NDUFA8-5033CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NDUFA8
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Cat.#:NDUFA8-5034CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NDUFA8
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Cat.#:NDUFA8-10991ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFA8
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Cat.#:NDUFA8-3915HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFA8 293 Cell Lysate
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Involved Pathway

NDUFA8 involved in several pathways and played different roles in them. We selected most pathways NDUFA8 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
ATP5I; NDUFS6; COX8C; ATP6V0CB; NDUFB6; ATP6V0A4; ATP6V0A2B; NDUFA3; ATP6V1G3; ATP4B
Metabolic pathways
udp; NT5C1B-RDH14; MT-ND4; CS; PIGS; ADKB; B3GNT1; MAT2AA; KYNU; MTMR8
Non-alcoholic fatty liver disease (NAFLD)
PIK3CG; INS2; MAP3K11; COX7A1; PRKAG2; CYCS; NDUFB11; PIK3R1; NDUFB9; IRS1
Alzheimers disease
LRP1; SDHB; TNFRSF1A; CAPN1; FADD; SDHA; NDUFB2; COX7A1; NDUFA6; NDUFA13
Parkinsons disease
SDHB; NDUFC1; UBE2L3; NDUFB4; SLC6A3; NDUFB3; UBE2G2; NDUFS1; ATP5B; NDUFB10
Huntingtons disease
POLR2J; TFAM; POLR2F; NDUFA5; NDUFB1; SDHC; MT-ATP6; NDUFC2; BBC3; ATP5A1

Protein Function

NDUFA8 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA8 itself. We selected most functions NDUFA8 had, and list some proteins which have the same functions with NDUFA8. You can find most of the proteins on our site.
Function
Related Protein
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFC1; NDUFA3; NDUFA7; NDUFB9; NDUFB4; NDUFA4; NDUFA10; NDUFA13; NDUFC2-KCTD14; NDUFS5
Function protein complex binding
Related Protein UGT1A6A; NRAS; NASP; ANKRD32; PDCL; KRIT1; CDK4; LRP2; NCOA1; CDK5RAP2

Interacting Protein

NDUFA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA8.
NDUFA2; NDUFS3; TBC1D4; MYC; RAB7A; NDUFA6; ATM; KLC3; P; NDUFA11; CNTROB; NDUFAF3; TIMMDC1; GOLT1B

NDUFA8 Related Articles

Jesinkey, SR; Korrapati, MC; et al. Atomoxetine Prevents Dexamethasone-Induced Skeletal Muscle Atrophy in Mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 351:663-673(2014).
Garrett, SM; Whitaker, RM; et al. Agonism of the 5-Hydroxytryptamine 1F Receptor Promotes Mitochondrial Biogenesis and Recovery from Acute Kidney Injury. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 350:257-264(2014).