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NECAB3

Official Full Name

N-terminal EF-hand calcium binding protein 3
Overview

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

NECAB3; N-terminal EF-hand calcium binding protein 3; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein , APBA2BP, SYTIP2; N-terminal EF-hand calcium-binding protein 3; dJ63M2.4; dJ63M2.5; EF hand calcium binding protein 3; EFCBP3; NIP1; XB51; SYTIP2; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein; Amyloid beta A4 protein binding family A member 2 binding protein; Amyloid beta A4 protein-binding family A member 2-binding protein; APBA2BP; N terminal EF hand calcium binding protein 3; NECA3_HUMAN; Nek2 interacting protein 1; Nek2-interacting protein 1; Neuronal calcium binding protein 3; Neuronal calcium-binding protein 3; STIP3; Synaptotagmin interacting protein 2; X11L binding protein 51; X11L-binding protein 51; EF-hand calcium binding protein 3; neuronal calcium-binding protein NECAB3; synaptotagmin interacting protein STIP3; amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	NECAB3-3888HCL	Recombinant Human NECAB3 293 Cell Lysate	HEK293	N/A	Inquiry
Human	NECAB3-3455H	Recombinant Human NECAB3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	NECAB3-10555M	Recombinant Mouse NECAB3 Protein	Mammalian Cell	His	Inquiry
Mouse	Necab3-4353M	Recombinant Mouse Necab3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	NECAB3-6000M	Recombinant Mouse NECAB3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	NECAB3-6000M-B	Recombinant Mouse NECAB3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Chicken	NECAB3-2545C	Recombinant Chicken NECAB3	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

NECAB3 involved in several pathways and played different roles in them. We selected most pathways NECAB3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NECAB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

NECAB3 has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NECAB3 itself. We selected most functions NECAB3 had, and list some proteins which have the same functions with NECAB3. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	ANXA4;NELL1;PCDHB5;EFCAB7;PCDHGA4;ACTN3B;ADAMTS13;ANXA1B;LCP1
protein binding	TRPV5;CBX5;PLAT;KRT8;ZNF572;COG8;CBX7;PRDM5;CCDC50

NECAB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NECAB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NECAB3.

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