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NEDD4L

  • Official Full Name

    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

  • Overview

    NEDD4 (neural precursor expressed, developmentally down-regulated protein 4) was originally identified as a gene that is highly expressed in the early mouse embryonic central nervous system. Subsequently, a family of NEDD4-like proteins have been defined
  • Synonyms

    NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; neural precursor cell expressed, developmentally down regulated 4 like; E3 ubiquitin-protein ligase NEDD4-like; KIAA0439; NEDD4 2; RSP5; ubiquitin;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • C
  • Myc
  • DDK
  • His
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEDD4L-3885HCL Recombinant Human NEDD4L 293 Cell Lysate HEK293 N/A
Human NEDD4L-034H Recombinant Human NEDD4L Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human NEDD4L-4142H Recombinant Human NEDD4L Protein (Glu629-Asp975), N-His tagged E.coli N-His Glu629-Asp975
Human NEDD4L-0438H Recombinant Human NEDD4L Protein (A2-D975), Tag Free E.coli No tag A2-D975
Human NEDD4L-0439H Recombinant Human NEDD4L Protein (A2-D975), His tagged E.coli His A2-D975
Mouse Nedd4l-4360M Recombinant Mouse Nedd4l Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEDD4L Related Research Area

NEDD4L involved in several pathways and played different roles in them. We selected most pathways NEDD4L participated on our site, such as Ubiquitin mediated proteolysis, Endocytosis, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD4L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisCUL1;CDC34A;NEDD4;FBXW8;PML;SOCS1A;TCEB1B;FBXW11;SOCS1
EndocytosisRABEP1;FOLR2;RAB11FIP4A;KDRL;EHD1;BF2;KIT;CHMP5;GRK6
Aldosterone-regulated sodium reabsorptionSGK1;INS2;ATP1A2;PIK3R5;ATP1A4;ATP1B3;PRKCA;ATP1A1;SCNN1G

NEDD4L has several biochemical functions, for example, ion channel binding, ligase activity, potassium channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD4L itself. We selected most functions NEDD4L had, and list some proteins which have the same functions with NEDD4L. You can find most of the proteins on our site.

Function Related Protein
ion channel bindingCAV3;PANX1;SCN3B;HERPUD1;NOS1;KCNAB1;KCNH1;AKAP6;CALM1
ligase activityUBE2F;TRIM62;NEURL3;BIRC3;ADSSL;NEDD4;TRIM24;RNF139;CDC34B
potassium channel inhibitor activityENSA;CAV3;KCNA5;RASA1;KCNK2;PTI;NEDD4L
potassium channel regulator activityKCNIP4;KCNIP2;YWHAE;ARPP19A;ARPP19;SGK1;DLG1;KCNMB4;ANK2
protein bindingCACNA2D1A;TMED1;BCCIP;GSTP1;SLAMF7;IGSF21B;NRP1B;USP8;LCAT
sodium channel inhibitor activityNEDD4L;NEDD4;PCSK9;CAMK2D;SCN1B;SLC14A2
sodium channel regulator activityPTPN3;FXYD5;FXYD6;GPD1L;SCN3B;FXYD1;PRSS30;GPLD1;SCN1B
ubiquitin protein ligase activityTRIM32;AMFR;RNF4;CBLC;MSL2B;MED17;RNF175;HERC6;RNF24
ubiquitin-protein transferase activityRNF217;FBXL14A;TRIM32;BIRC5A;LRSAM1;FBXO40.1;RNF182;BRAP;TRAF4

NEDD4L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD4L here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD4L.

DAZAP2; SCNN1B; RAPGEF2; AMOT; MED28; FBXL15; ARHGDIA; YWHAG; LAPTM5; SMAD2; GORAB; WNK1; AATF; RNF11; vpr; YWHAH; TOLLIP

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