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NEDD8

  • Official Full Name

    neural precursor cell expressed, developmentally down-regulated 8

  • Overview

    Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
  • Synonyms

    NEDD8; neural precursor cell expressed, developmentally down-regulated 8; Nedd 8; neddylin; ubiquitin-like protein Nedd8; NEDD-8; FLJ43224; MGC104393; MGC125896; MGC125897;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEDD8-160H Active Recombinant Human NEDD8 E.coli N/A
Human NEDD8-2381H Recombinant Human NEDD8, GST-tagged E.coli GST
Human NEDD8-1253H Recombinant Human NEDD8, GST-tagged E.coli GST 1-81aa
Human NEDD8-29619TH Recombinant Human NEDD8, His-tagged E.coli His
Human NEDD8-1388H Recombinant Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 8, His-tagged Human His
Human NEDD8-2018H Recombinant Human NEDD8 Protein, His-tagged E.coli His Met1-Gly76
Human NEDD8-161H Recombinant Human NEDD8 Protein, His-SUMO-tagged E.coli His-SUMO Met1-Gly76
Human NEDD8-4677H Recombinant Human NEDD8 Protein (Met1-Gly76), N-His tagged E.coli N-His Met1-Gly76
Human NEDD8-2019H Recombinant Human NEDD8 Protein, His-tagged E.coli His 1-81 aa
Mouse NEDD8-10561M Recombinant Mouse NEDD8 Protein Mammalian Cell His
Mouse NEDD8-6002M-B Recombinant Mouse NEDD8 Protein Pre-coupled Magnetic Beads HEK293
Mouse NEDD8-6002M Recombinant Mouse NEDD8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NEDD8-3951R Recombinant Rat NEDD8 Protein Mammalian Cell His
Rat NEDD8-3609R-B Recombinant Rat NEDD8 Protein Pre-coupled Magnetic Beads HEK293
Rat NEDD8-3609R Recombinant Rat NEDD8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NEDD8-2995R Recombinant Rhesus monkey NEDD8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NEDD8-2814R-B Recombinant Rhesus Macaque NEDD8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NEDD8-2814R Recombinant Rhesus Macaque NEDD8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NEDD8-11468Z Recombinant Zebrafish NEDD8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEDD8 Related Articles
  • NEDD8 Related Research Area

NEDD8 involved in several pathways and played different roles in them. We selected most pathways NEDD8 participated on our site, such as Signal Transduction, Signaling by TGF-beta Receptor Complex, TGF-beta receptor signaling activates SMADs, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEDD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signal TransductionARHGAP28;ARHGAP29;ASH2L;SEPT7;ACKR4;RIT2;TRH;RLN3A;SKI
Signaling by TGF-beta Receptor ComplexUCHL5;TRIM33;SKIA;SKILB;NEDD8L;SKIB;STRAP;USP15;PMEPA1
TGF-beta receptor signaling activates SMADsUCHL5;PMEPA1;STRAP;NEDD8L;USP15;NEDD8
p53 pathwayCSNK1G3;CSE1L;RASSF1;HUWE1;TTC5;TRIM28;NEDD8;PPP1R13L;SMYD2

NEDD8 has several biochemical functions, for example, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEDD8 itself. We selected most functions NEDD8 had, and list some proteins which have the same functions with NEDD8. You can find most of the proteins on our site.

Function Related Protein
protein bindingTRMT112;CASP2;TMEM31;CUL4B;TRIM71;SRGAP1;TRIM54;KDM2B;GMDS
ubiquitin protein ligase bindingRPA3;CDC34A;TMEM173;UBE2V2;YWHAE;TRAF5;DERL1;HSPA1A;TRP53

NEDD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEDD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEDD8.

CUL1; UBE2M; RPL11; NAE1; CUL5

Wang, Q; Burles, K; et al. Ectromelia Virus Encodes a BTB/kelch Protein, EVM150, That Inhibits NF-kappa B Signaling. JOURNAL OF VIROLOGY 88:4853-4865(2014).
Amaral, AT; Ordonez, JL; et al. Innovative Therapies in Ewing Sarcoma. ADVANCES IN ANATOMIC PATHOLOGY 21:44-62(2014).
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