neil2
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  • Official Full Name
  • nei endonuclease VIII-like 2
  • Background
  • NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate;the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA;strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed 12509226)).
  • Synonyms
  • NEIL2; nei endonuclease VIII-like 2 (E. coli); nei like 2 (E. coli); endonuclease 8-like 2; FLJ31644; MGC2832; MGC4505; NEH2; nei like 2; nei homolog 2; nei-like protein 2; endonuclease VIII-like 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimi
Cat.#:NEIL2-1963HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Nei Endonuclease VIII-like 2 (E. coli), His-tagged
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Cat.#:NEIL2 -1542HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEIL2 protein
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Cat.#:NEIL2-15866HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEIL2, His-tagged
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Cat.#:NEIL2-2042HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Nei Endonuclease VIII-like 2 (E. coli)
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Cat.#:NEIL2-5185CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NEIL2
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Cat.#:NEIL2-586HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Nei Endonuclease VIII-like 2 (E. coli)
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Cat.#:NEIL2-3881HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NEIL2 293 Cell Lysate
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Involved Pathway

NEIL2 involved in several pathways and played different roles in them. We selected most pathways NEIL2 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEIL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
POLE2; PARP2; PARP4; mutY; PNKP; SMUG1; LIG1; APEX2; POLD4; PARP1

Protein Function

NEIL2 has several biochemical functions, for example, DNA-(apurinic or apyrimidinic site) lyase activity, damaged DNA binding, hydrolase activity, hydrolyzing N-glycosyl compounds. Some of the functions are cooperated with other proteins, some of the functions could acted by NEIL2 itself. We selected most functions NEIL2 had, and list some proteins which have the same functions with NEIL2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein ALKBH1; HMGA1; HMGA1-RS1; HMGA2; APLF; NEIL1; HMGA1B; HMGA1A; NEIL2; RPS3
Function damaged DNA binding
Related Protein XRCC6; TRP53; POLK; RPS3; FANCG; RAD23B; CREBBP; APEX1; RPA3; TP63
Function hydrolase activity, hydrolyzing N-glycosyl compounds
Related Protein UNGA; MAN2A1; MAN2A2; NEIL2; TDG.1
Function microtubule binding
Related Protein MAP1B; GABARAPA; KIF3CB; MAP6; SPAST; WDR81; CAMSAP1; GOLSYN; MTUS2; FGF13
Function protein binding
Related Protein PIAS1; CYBRD1; CD1d1; LGI1; ASPH; CIT; ODAM; ATP5B; NSUN4; ACHE
Function zinc ion binding
Related Protein PDZRN3B; RNF144A; CHORDC1; BMI1; ZDHHC20; POLR2K; MMP9; MTA1; RNF148; NR4A2A

Interacting Protein

NEIL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEIL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEIL2.
TRIM27; MEOX1; REL