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NEIL2

  • Official Full Name

    nei endonuclease VIII-like 2

  • Overview

    NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate;the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA;strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed 12509226)).
  • Synonyms

    NEIL2; nei endonuclease VIII-like 2 (E. coli); nei like 2 (E. coli); endonuclease 8-like 2; FLJ31644; MGC2832; MGC4505; NEH2; nei like 2; nei homolog 2; nei-like protein 2; endonuclease VIII-like 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimi;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • C
  • Myc
  • DDK
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEIL2-15866H Recombinant Human NEIL2, His-tagged E.coli His 1-332aa
Human NEIL2-2042H Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) E.coli N/A
Human NEIL2-586H Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) E.coli N/A
Human NEIL2-1963H Recombinant Human Nei Endonuclease VIII-like 2 (E. coli), His-tagged E.coli His
Human NEIL2 -1542H Recombinant Human NEIL2 protein E.coli N/A
Human NEIL2-3881HCL Recombinant Human NEIL2 293 Cell Lysate HEK293 N/A
Human NEIL2-3048H Recombinant Human NEIL2 protein, His-tagged E.coli His 239 - 332 aa
Human NEIL2-351H Recombinant Human NEIL2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Neil2-4366M Recombinant Mouse Neil2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken NEIL2-5185C Recombinant Chicken NEIL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NEIL2 involved in several pathways and played different roles in them. We selected most pathways NEIL2 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEIL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Base excision repairUNGA;POLE;PNKP;xthA;POLD2;NEIL1;MUTYH;SMUG1;XRCC1

NEIL2 has several biochemical functions, for example, DNA-(apurinic or apyrimidinic site) lyase activity, damaged DNA binding, hydrolase activity, hydrolyzing N-glycosyl compounds. Some of the functions are cooperated with other proteins, some of the functions could acted by NEIL2 itself. We selected most functions NEIL2 had, and list some proteins which have the same functions with NEIL2. You can find most of the proteins on our site.

Function Related Protein
DNA-(apurinic or apyrimidinic site) lyase activityAPLF;HMGA2;RPS3;NEIL1;NEIL3;HMGA1A;APEX1;APEX2;NTHL1
damaged DNA bindingNEIL1;RAD23AB;APTX;TP53BP1;FEN1;POLH;UNG;FANCG;RAD18
hydrolase activity, hydrolyzing N-glycosyl compoundsUNGA;NEIL2;TDG.1;MAN2A1;MAN2A2
microtubule bindingCHP;RCC2;LRPPRC;TXNDC3;KIF9;DPYSL2;NEIL2;TRPV4;MAP4
protein bindingKIF1C;SPPL2B;PEX11A;ARHGEF15;PPP2R5E;PTGER4;S100P;RACGAP1;DBF4B
zinc ion bindingMTA2;LNPEP;MMP30;RNF11B;DPEP1;TRIM36;RXRB;HRG;ZNF257

NEIL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEIL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEIL2.

TRIM27; MEOX1; REL

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