nek7
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  • Official Full Name
  • NIMA (never in mitosis gene a)-related kinase 7
  • Background
  • NEK7 [NIMA(never in mitosis gene a)-related kinase 7] is a member of the NIMA-related serine/threonine kinase family. NEK7 has been shown localize to spindle poles and to be required for mitotic spindle formation and cytokinesis.
  • Synonyms
  • NEK7; NIMA (never in mitosis gene a)-related kinase 7; serine/threonine-protein kinase Nek7; nimA-related protein kinase 7; never in mitosis A-related kinase 7
Cat.#:NEK7-588HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NEK7 Protein, MYC/DDK-tagged
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Cat.#:NEK7-28259THTag:
Source (Host):Species:Human
Product nameRecombinant Human NEK7
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Cat.#:NEK7-348HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NIMA-related kinase 7, His-tagged
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Cat.#:NEK7-761HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human NEK7, His & GST tagged
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Cat.#:NEK7-816HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NEK7
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Cat.#:NEK7-10577MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NEK7 Protein
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Cat.#:NEK7-3955RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NEK7 Protein
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Cat.#:NEK7-2999RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NEK7 Protein, His-tagged
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Cat.#:NEK7-2922CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NEK7
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Cat.#:NEK7-1043ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NEK7
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Cat.#:NEK7-371HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NEK7, GST-tagged, Active
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Cat.#:NEK7-661HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEK7, Active
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Cat.#:NEK7-654HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human NEK7 cell lysate
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Involved Pathway

NEK7 involved in several pathways and played different roles in them. We selected most pathways NEK7 participated on our site, such as Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of NIMA Kinases NEK9, NEK6, NEK7
NEK9; NEK7; NEK6
Cell Cycle
GORASP2; MAPRE1; YWHABB; DBF4; CDC20; MAD2L1; KAT5; CHEK1; BORA; BUB1
Cell Cycle, Mitotic
APITD1; DCTN1A; LIN9; KIF2A; NEK9; CSNK1E; CDK5RAP2; TUBB4B; GORASP1; CEP76
M Phase
GOLGA2; MCPH1; PDS5B; SET; SKA1; CNEP1R1; INCENP; SPC25; PHF8; CDCA8
Mitotic Prophase
NEK7; SETA; ENSA; ARPP19; SMC2; PHF8; MASTL; VRK2; VRK1; ENSAA
Nuclear Envelope Breakdown
CTDNEP1; CTDNEP1B; NEK9; TMEM188; CNEP1R1; NEK6; CTDNEP1A; NEK7; DULLARD
Nuclear Pore Complex (NPC) Disassembly
NEK7; NEK6; NEK9

Protein Function

NEK7 has several biochemical functions, for example, ATP binding, metal ion binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK7 itself. We selected most functions NEK7 had, and list some proteins which have the same functions with NEK7. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACTB2; ATP1A1A.5; ERBB3; SARS; PAPOLA; UBE2D2A; MAPK14A; PRPS1; ATP6V1AA; ACTR2B
Function metal ion binding
Related Protein RCV1; ADSSL; SMAD2; ZNF254; CAR5A; KLF18; MOB4; ZNF35; TSNAX; PKM
Function protein serine/threonine kinase activity
Related Protein TGFBR1A; NIM1; MLKL; CDK12; TLK2; DCLK1A; SGK2; ALPK1; TLK1B; MAP2K2A

Interacting Protein

NEK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK7.
NEK9; NEK6; q7ard3_yerpe; Nek9

NEK7 Related Articles

Wang, R; Song, Y; et al. The expression of Nek7, FoxM1, and Plk1 in gallbladder cancer and their relationships to clinicopathologic features and survival. CLINICAL & TRANSLATIONAL ONCOLOGY 15:626-632(2013).
Hayward, DG; Newbatt, Y; et al. Identification by High-Throughput Screening of Viridin Analogs as Biochemical and Cell-Based Inhibitors of the Cell Cycle-Regulated Nek2 Kinase. JOURNAL OF BIOMOLECULAR SCREENING 15:918-927(2010).
O'Regan, L; Fry, AM; et al. The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis. MOLECULAR AND CELLULAR BIOLOGY 29:3975-3990(2009).
Belham, C; Roig, J; et al. A mitotic cascade of NIMA family kinases - Nercc1/Nek9 activates the Nek6 and Nek7 kinases. JOURNAL OF BIOLOGICAL CHEMISTRY 278:34897-34909(2003).