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NEU1

  • Official Full Name

    sialidase 1 (lysosomal sialidase)

  • Overview

    The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as protective protein). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008]
  • Synonyms

    NEU1; sialidase 1 (lysosomal sialidase); NEU; NANH; SIAL1; sialidase-1; G9 sialidase; exo-alpha-sialidase; lysosomal sialidase; acetylneuraminyl hydrolase; N-acetyl-alpha-neuraminidase 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEU1-156H Recombinant Human NEU1, His-tagged HEK293 His
Human NEU1-1266H Recombinant Human NEU1, His-tagged E.coli His 1-415aa
Human NEU1-579H Recombinant Human NEU1 protein, His-tagged E.coli His Ala141~His286
Human NEU1-580H Recombinant Human NEU1 protein, His-tagged E.coli His Ala47~Leu415
Human NEU1-3871HCL Recombinant Human NEU1 293 Cell Lysate HEK293 N/A
Human NEU1-1501H Recombinant Human NEU1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NEU1-323H Recombinant Human NEU1 Protein, His-tagged E. coli His 48-415 aa
Human NEU1-178HFL Active Recombinant Full Length Human NEU1 Protein, C-Flag-tagged Mammalian cells Flag
Human NEU1-4684H Recombinant Human NEU1 Protein (Glu48-Leu415), C-His tagged Mammalian cells C-His Glu48-Leu415
Human NEU1-4685H Recombinant Human NEU1 Protein (Ala110-Pro262), N-His tagged E.coli N-His Ala110-Pro262
Human NEU1-5667H Recombinant Human NEU1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NEU1-4686H Recombinant Human NEU1 Protein (Ala47-Leu415), C-His tagged Mammalian cells C-His Ala47-Leu415
Human NEU1-1501H-B Recombinant Human NEU1 Protein Pre-coupled Magnetic Beads HEK293
Mouse NEU1-10590M Recombinant Mouse NEU1 Protein Mammalian Cell His
Mouse Neu1-5480M Recombinant Mouse Neu1 protein, His-tagged Yeast His 42-409aa
Mouse NEU1-6018M-B Recombinant Mouse NEU1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Neu1-4378M Recombinant Mouse Neu1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Neu1-3272M Recombinant Mouse Neu1 protein, His-tagged E.coli His 42-409aa
Mouse NEU1-6018M Recombinant Mouse NEU1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NEU1-3005R Recombinant Rhesus monkey NEU1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NEU1-2824R Recombinant Rhesus Macaque NEU1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NEU1-2824R-B Recombinant Rhesus Macaque NEU1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NEU1-4014Z Recombinant Zebrafish NEU1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEU1 Related Articles
  • NEU1 Related Research Area

NEU1 involved in several pathways and played different roles in them. We selected most pathways NEU1 participated on our site, such as Other glycan degradation, Sphingolipid metabolism, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEU1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Other glycan degradationNEU3;NEU3.2;NEU2;MAN2B1;HEXDC;AGA;FUCA1.2;NEU4;HEXB
Sphingolipid metabolismARSE;PPM1L;VAPB;SPTLC3;CERS4A;GLTPA;CERS1;DEGS1;ARSF
LysosomeSUMF1;ATP6V0CB;AP1S3;CTSG;ENTPD4;ASAH1;AP3D1;ABCB9;CTSSB.2

NEU1 has several biochemical functions, for example, exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, exo-alpha-(2->8)-sialidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEU1 itself. We selected most functions NEU1 had, and list some proteins which have the same functions with NEU1. You can find most of the proteins on our site.

Function Related Protein
exo-alpha-(2->3)-sialidase activityNEU3;NEU2;NEU4;NEU1
exo-alpha-(2->6)-sialidase activityNEU2;NEU1;NEU3;NEU4
exo-alpha-(2->8)-sialidase activityNEU3;NEU4;NEU1;NEU2
exo-alpha-sialidase activityNEU3.1;NEU3.4;NEU3.2;NEU4;NEU3;ST3GAL5L;NEU1;NEU3.5;NEU3.3

NEU1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEU1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEU1.

GLB1; JUNB; EEF1A1; tktA; pi3p; ELN; Rcc1; VAPA

Guerrier, T; Pochard, P; et al. TLR9 expressed on plasma membrane acts as a negative regulator of human B cell response. JOURNAL OF AUTOIMMUNITY 51:23-29(2014).
Alghamdi, F; Guo, M; et al. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. CELLULAR SIGNALLING 26:1355-1368(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is there ongoing research focused on NEU1 protein and its clinical applications? 11/06/2021

Yes, there is ongoing research aimed at understanding the molecular mechanisms of NEU1 and developing potential therapeutic interventions for associated disorders.

How does NEU1 deficiency affect individuals? 07/08/2021

NEU1 deficiency can lead to a group of rare genetic disorders known as sialidosis, which can cause a range of symptoms including intellectual disabilities, muscle weakness, and skeletal abnormalities.

Is NEU1 protein involved in any other medical conditions besides sialidosis? 02/03/2021

NEU1 protein has also been implicated in certain types of cancer and neurodegenerative diseases.

Can NEU1 deficiency lead to other medical complications? 05/30/2020

Yes, NEU1 deficiency can lead to additional complications such as hepatosplenomegaly (enlargement of the liver and spleen), seizures, and difficulty swallowing.

Are there any specific treatments available for NEU1 deficiency or sialidosis? 03/12/2017

Currently, there are no specific cures for NEU1 deficiency or sialidosis. Treatment is generally supportive and aims to manage the symptoms.

Customer Reviews (3)

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Reviews
02/18/2023

    Its purity and reliability ensure reliable and reproducible results in a variety of research applications.

    06/25/2021

      The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.

      11/01/2018

        The NEU1 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).

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