NEU2
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Official Full Name
sialidase 2 (cytosolic sialidase)
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Overview
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. -
Synonyms
NEU2; sialidase 2 (cytosolic sialidase); sialidase-2; N acetyl alpha neuraminidase 2; SIAL2; Cytosolic sialidase; MGC129579; N-acetyl-alpha-neuraminidase 2; NEUR2_HUMAN; Neuraminidase 2; OTTHUMP00000164374; Sialidase 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chinese hamster
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- His
- His (Fc)
- Avi
- Myc
- His|T7
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- NEU2 Related Articles
NEU2 involved in several pathways and played different roles in them. We selected most pathways NEU2 participated on our site, such as Other glycan degradation, Sphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEU2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other glycan degradation | GLB1;MAN2B1;FUCA1.1;GBA2;NEU3.1;HEXDC;NEU3.2;NEU3.3;HEXB |
| Sphingolipid metabolism | ASAH2;ARSD;DEGS1;CERS5;CERS2A;GLB1;NEU3.5;PPAP2D;PPAP2CB |
NEU2 has several biochemical functions, for example, exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, exo-alpha-(2->8)-sialidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEU2 itself. We selected most functions NEU2 had, and list some proteins which have the same functions with NEU2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exo-alpha-(2->3)-sialidase activity | NEU2;NEU4;NEU3;NEU1 |
| exo-alpha-(2->6)-sialidase activity | NEU3;NEU2;NEU4;NEU1 |
| exo-alpha-(2->8)-sialidase activity | NEU2;NEU3;NEU4;NEU1 |
| protein binding | BSCL2;ZBP1;TTR;FOXG1;RRP8;PGBD1;CRYBB3;GADD45A;EIF2B1 |
NEU2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEU2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEU2.
NOTCH2NL
- Q&As
- Reviews
Q&As (6)
Ask a questionIn the experiment, the NEU2 gene can be introduced into the expression vector by gene cloning technology, and then the NEU2 protein can be expressed in E. coli or eukaryotic cells.
Studies have shown that NEU2 protein may be associated with some tumor diseases, especially abnormal glucose metabolism and cell proliferation of tumor cells.
Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role of NEU2 protein and disease mechanisms in vivo. These animal models can be used to study the effects of NEU2 protein on glycoprotein degradation, cell growth, and tumorigenesis.
The function of NEU2 protein can be studied by gene knockout, transgenesis, protein interaction and other techniques.
The expression level of NEU2 protein can be detected by immunohistochemistry, immunofluorescence staining, western blotting, etc.
Studies have shown that NEU2 protein can interact with other proteins, such as enzymes related to the degradation of polysaccharide chains, and participate in the degradation process of polysaccharide chains.
Customer Reviews (3)
Write a reviewThis protein performed well in experiments and was a reliable choice.
The impurities are not obvious, clear and transparent, and the purity is very high.
This one is very convenient to use and works very well, I highly recommend them.
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