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NEU3

  • Official Full Name

    sialidase 3 (membrane sialidase)

  • Overview

    This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
  • Synonyms

    NEU3; sialidase 3 (membrane sialidase); SIAL3; sialidase-3; neuraminidase 3; membrane sialidase; ganglioside sialidase; N-acetyl-alpha-neuraminidase 3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEU3-708H Recombinant Human NEU3 Mammalian Cell His
Human NEU3-301462H Recombinant Human NEU3 protein, GST-tagged E.coli GST Met193-Glu326
Human NEU3-752H Recombinant Human NEU3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NEU3-4949H Recombinant Human NEU3 protein, His-tagged E.coli His 2-428aa
Human NEU3-4603H Recombinant Human NEU3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NEU3-1503H-B Recombinant Human NEU3 Protein Pre-coupled Magnetic Beads HEK293
Human NEU3-3932H Recombinant Human NEU3 Protein (Met1-Asn428), C-His tagged E.coli C-His Met1-Asn428
Human NEU3-3933H Recombinant Human NEU3 Protein (Met1-Asn428), C-His tagged Mammalian cells C-His Met1-Asn428
Human NEU3-35HFL Active Recombinant Full Length Human NEU3 Protein, C-Flag-tagged Mammalian cells Flag
Human NEU3-1503H Recombinant Human NEU3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Neu3-4838M Recombinant Mouse Neu3 protein, His-tagged E.coli His 1-418aa
Mouse Neu3-4380M Recombinant Mouse Neu3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat NEU3-3961R Recombinant Rat NEU3 Protein Mammalian Cell His
Rat NEU3-3619R-B Recombinant Rat NEU3 Protein Pre-coupled Magnetic Beads HEK293
Rat NEU3-3619R Recombinant Rat NEU3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEU3 Related Articles

NEU3 involved in several pathways and played different roles in them. We selected most pathways NEU3 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Glycosphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEU3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationCSNK1D;ALG14;SEC22A;PREB;TMED2;MAGT1;MAN1A2;TRAPPC2L;ST6GALNAC1.2
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinZNF408;ALG10B;DPAGT1;ST6GAL2B;ST6GALNAC1.2;NANP;ALG2;ST8SIA2;ST3GAL3A
Glycosphingolipid metabolismARSD;GLTPA;ARSK;NEU4;NEU3;ARSE;ARSF;GLB1L;ARSI
MetabolismNUDT4;AMD2;PLCD3;NUDT15;PDK3;CYP2S1;HELZ2;CKMT1B;CYP2K8
Metabolism of lipids and lipoproteinsACOT6;NFYBB;FIG4;SREBF2;PIK3R6;SLC27A2A;YAP1;PITPNB;CSNK1G2
Metabolism of proteinsTBCB;SCMH1;EEF1A1;F9B;SCFD1;CPB1;LMCD1;TBCE;IGF2B
Other glycan degradationNEU3.2;MAN2B2;HEXB;HEXDC;MAN2C1;FUCA1.2;AGA;NEU3;HEXA
Post-translational protein modificationNAPAB;SMC5;NSMCE2;NEU3;MUC4;NAPB;SEC23IP;SEC22A;ALG10B

NEU3 has several biochemical functions, for example, alpha-sialidase activity, exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NEU3 itself. We selected most functions NEU3 had, and list some proteins which have the same functions with NEU3. You can find most of the proteins on our site.

Function Related Protein
alpha-sialidase activity
exo-alpha-(2->3)-sialidase activityNEU3;NEU4;NEU1;NEU2
exo-alpha-(2->6)-sialidase activityNEU3;NEU2;NEU1;NEU4
exo-alpha-(2->8)-sialidase activityNEU4;NEU3;NEU1;NEU2
exo-alpha-sialidase activityNEU3.2;NEU3;NEU4;NEU3.1;NEU3.3;NEU3.4;ST3GAL5L;NEU3.5;NEU1

NEU3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEU3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEU3.

Tringali, C; Silvestri, I; et al. Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles. BMC CANCER 14:-(2014).
Alghamdi, F; Guo, M; et al. A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes. CELLULAR SIGNALLING 26:1355-1368(2014).
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