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NFATC1

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

  • Overview

    The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
  • Synonyms

    NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; nuclear factor of activated T-cells, cytoplasmic 1; NF ATC; NFAT2; NFATc; NF-ATc1; NFAT transcription complex cytosolic component; NF-ATC; MGC138448;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NFATC1-29253TH Recombinant Human NFATC1 N/A
Human NFATC1-1274H Recombinant Human Nuclear Factor Of Activated T-cells, Cytoplasmic, Calcineurin-Dependent 1, His-tagged E.coli His
Human NFATC1-7051H Recombinant Human NFATC1, GST-tagged Sf9 Insect Cell GST Full length
Human NFATC-1474H Recombinant Human NFATC1, GST-tagged Sf9 Insect Cell GST
Human NFATC1-1273H Recombinant Human NFATC1, His-tagged E.coli His 1-351aa
Human NFATC1-3858HCL Recombinant Human NFATC1 293 Cell Lysate HEK293 N/A
Human NFATC1-3859HCL Recombinant Human NFATC1 293 Cell Lysate HEK293 N/A
Human NFATC1-4340H Recombinant Human NFATC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Nfatc1-1822M Recombinant Mouse Nfatc1 Protein, His-tagged E.coli N-His Ser153-Thr326
Mouse Nfatc1-1823M Recombinant Mouse Nfatc1 Protein, His-tagged E.coli N-His Pro411-Ala593
Mouse Nfatc1-4387M Recombinant Mouse Nfatc1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish NFATC1-4190Z Recombinant Zebrafish NFATC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NFATC1 Related Articles
  • NFATC1 Related Research Area
  • NFATC1 Related Signal Pathway

NFATC1 involved in several pathways and played different roles in them. We selected most pathways NFATC1 participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNB2A;MAP3K12;CDC42L;RASGRF2B;TNF;MEF2CB;PPP3R1B;RAF1A;CACNA2D4
cGMP-PKG signaling pathwayIRS1;Adcy4;PLCB2;ATP2A1;PDE2A;PIK3CG;KCNJ8;SLC25A31;GNAI2
cAMP signaling pathwayPAK1;RHOA;HCAR2;NFATC1;MAPK9;MLLT4;GRIN3A;CALM1;HCN4
Wnt signaling pathwayBAMBIA;PPARD;FOSL1;FBXW11;AXIN1;SMAD3;WNT7A;CUL1A;NKD1
Osteoclast differentiationNCF2;NCF4;TNFSF11;LILRB2;MAPK9;IFNG;FCGR3A;TEC;PPP3CB
Natural killer cell mediated cytotoxicityKLRK1;PLCG1;GZMB;PPP3R1;VAV3;IFNA17;FCGR3B;IFNA21;IFNB1
T cell receptor signaling pathwayOXSR1A;MAP3K14;NFKBIE;VAV1;MAP2K2;CBLC;VAV2;CARD11;MUC1
B cell receptor signaling pathwayCD79A;FCGR2B;ITK;IFITM1;AKT2;CDK2;MAPK1;BLK;PIK3CA
Oxytocin signaling pathwayPRKCA;PPP1CC;KRAS;PLCB3;PLCB4;RHOA;PPP3CB;MAP2K5;CAMK2B
Hepatitis BSTAT5A;PRKCB;MMP9;IFNA4;TLR4;GRB2;CASP9;STAT5B;IFNAR1
HTLV-I infectionFZD2;MRAS;FZD10;WNT4;MAPK8;PRKACG;IL2RA;HLA-A;TNF
Inflammatory bowel disease (IBD)FOXP3;TGFB1;IL17F;Il23a; Il12b;HLA-DRB1;IL23;IL21;IL22;IFNG

NFATC1 has several biochemical functions, for example, FK506 binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC1 itself. We selected most functions NFATC1 had, and list some proteins which have the same functions with NFATC1. You can find most of the proteins on our site.

Function Related Protein
FK506 bindingFKBP1A;FKBP1AA;FKBP6;FKBP14;FKBP9;FKBP10;FKBP7;FKBP1AB;NFATC1
RNA polymerase II distal enhancer sequence-specific DNA bindingCDX2;ESRRB;ATF2;CDX1;NFKB1;MIXL1;ARID3B;NFE2L2;SFPQ
RNA polymerase II transcription factor bindingSFPI1;GATA1A;ANKRD1;SPI1;TBX3;GSC;KLF4;GATA2B;T
mitogen-activated protein kinase p38 bindingTAB1;RPS6KA4;SPAG9;PRMT1;NFATC1
protein bindingSMAD3;PMM2;RFFL;SNX18;NEDD4;RFC2;STUB1;CDKN2D;IGF2R
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingSOX7;SOX17;NKX2-5;THRA;MYOG;SOX9;CREB1;MEF2C;POU3F3
transcription factor activity, sequence-specific DNA bindingMAFG;SPI1;TFE3;MNX1;OTX1A;MYCB;MTA1;POU2F1A;DMRT2A
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingHOXB5;MEOX2;SIX3;FUBP1;ZEB2;MIXL1;CDX1;TARDBP;REL

NFATC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC1.

OGT; Ppp3cb; JAK3; icam1_human_nfkb-intron_dna-probe; YWHAZ; icam1_human_gene; il2_human_gene

Wang, HC; Jiang, WP; et al. Fibroblasts isolated from a keratocystic odontogenic tumor promote osteoclastogenesis in vitro via interaction with epithelial cells. ORAL DISEASES 21:170-177(2015).
Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).
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