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NFATC1

Official Full Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Overview

The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
Synonyms

NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; nuclear factor of activated T-cells, cytoplasmic 1; NF ATC; NFAT2; NFATc; NF-ATc1; NFAT transcription complex cytosolic component; NF-ATC; MGC138448;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Sf9 Insect Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFATC1-29253TH	Recombinant Human NFATC1		N/A		Inquiry
Human	NFATC1-1274H	Recombinant Human Nuclear Factor Of Activated T-cells, Cytoplasmic, Calcineurin-Dependent 1, His-tagged	E.coli	His		Inquiry
Human	NFATC1-7051H	Recombinant Human NFATC1, GST-tagged	Sf9 Insect Cell	GST	Full length	Inquiry
Human	NFATC-1474H	Recombinant Human NFATC1, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	NFATC1-1273H	Recombinant Human NFATC1, His-tagged	E.coli	His	1-351aa	$319 / 25ug
Human	NFATC1-3858HCL	Recombinant Human NFATC1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NFATC1-3859HCL	Recombinant Human NFATC1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NFATC1-4340H	Recombinant Human NFATC1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Nfatc1-1822M	Recombinant Mouse Nfatc1 Protein, His-tagged	E.coli	N-His	Ser153-Thr326	Inquiry
Mouse	Nfatc1-1823M	Recombinant Mouse Nfatc1 Protein, His-tagged	E.coli	N-His	Pro411-Ala593	Inquiry
Mouse	Nfatc1-4387M	Recombinant Mouse Nfatc1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	NFATC1-4190Z	Recombinant Zebrafish NFATC1	Mammalian Cell	His		Inquiry

NFATC1 involved in several pathways and played different roles in them. We selected most pathways NFATC1 participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	MECOM;RAP1AA;RPS6KA6;CACNA1H;MAPK4;TNF;FGF5;MAP3K5;FGF22
cGMP-PKG signaling pathway	PIK3CB;GUCY1B3;PPP3CC;MEF2A;PDE3B;MAPK1;PRKCE;PPP1CA;PPP3R2
cAMP signaling pathway	HTR1A;VAV1;PIK3CG;CREB3L2;ATP1B2;ATP1B1;HCAR3;GRIA1;PLD1
Wnt signaling pathway	WNT2BB;TCF7L2;EP300;SENP2;PPP3R1B;RHOAB;RAC3A;CAMK2B1;RHOAC
Osteoclast differentiation	CAMK4;IFNG;TNFRSF11B;CYLD;STAT2;PPARG;LILRB4;RELA;OSCAR
Natural killer cell mediated cytotoxicity	KLRD1;ICAM2;MAP2K2;PIK3R5;HRAS;KIR2DS3;NCR2;LAT;HLA-E
T cell receptor signaling pathway	CBLC;MAPK11;MAP3K14;DLG1;FYN;VAV1;MAPK9;IL4;CD3D
B cell receptor signaling pathway	PLEKHA1;BLNK;ACTR3;CRKL;GSK3B;STAP1;CD79B;ARPC4;DUSP4
Oxytocin signaling pathway	CALM1;CALM3;TRPM2;CACNA2D4;GNAI2;OXT;GNAQ;CAMK1;MEF2C
Hepatitis B	MAVS;Fasl;IFNA8;PIK3R5;CREB5;IL-8;IKBKB;BAX;IKBKG
HTLV-I infection	ANAPC1;CCND3;TLN1;VDAC1;CDC27;MAP3K1;TP53;TGFBR2;H2-Q10
Inflammatory bowel disease (IBD)	IL1A;Il4ra;IL4R;IL17A;HLA-DOA;NFATC1;HLA-DRB5;STAT4;HLA-DRB4

NFATC1 has several biochemical functions, for example, FK506 binding, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC1 itself. We selected most functions NFATC1 had, and list some proteins which have the same functions with NFATC1. You can find most of the proteins on our site.

Function	Related Protein
FK506 binding	FKBP11;FKBP14;FKBP8;NFATC1;TTC9C;FKBP10B;FKBP9;FKBP1AB;FKBP4
RNA polymerase II distal enhancer sequence-specific DNA binding	ZBTB16;NR2F6;H2AFZ;GZF1;MEOX2;NFE2L1;BACH1;RELA;HNRNPC
RNA polymerase II transcription factor binding	NFATC1;CHST13;GATA2B;DHX9;GATA6;HCLS1;MIXL1;TRP53;XBP1
mitogen-activated protein kinase p38 binding	NFATC1;RPS6KA4;TAB1;PRMT1;SPAG9
protein binding	DCDC2B;CENPT;CSNK1G1;AIMP1;LMX1B;LTA4H;SERPINE2;FCER1G;BCL2L10
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	SRF;NKX2;GTF2IRD1;PKNOX1;THRA;SNAI2;SOX10;ATF2;SOX9
transcription factor activity, sequence-specific DNA binding	FOXG1A;IRF6;TBX4;RARAA;GPBP1;SNAPC4;ZNF396;POU3F2B;SLC12A9
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	SPI1;NFATC1;ARID3B;HCFC1;MIXL1;NFE2L1;PROP1;CUX1;HMGA1

NFATC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC1.

OGT; Ppp3cb; JAK3; icam1_human_nfkb-intron_dna-probe; YWHAZ; icam1_human_gene; il2_human_gene

Wang, HC; Jiang, WP; et al. Fibroblasts isolated from a keratocystic odontogenic tumor promote osteoclastogenesis in vitro via interaction with epithelial cells. ORAL DISEASES 21:170-177(2015).

Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).

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