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NFATC2

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

  • Overview

    The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
  • Synonyms

    NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, cytoplasmic 2; NF ATP; NFAT1; NFATp; NF-ATc2; NFAT pre-existing subunit; T cell transcription factor NFAT1; T-cell transcription factor;

  • Recombinant Proteins
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • C
  • Myc
  • DDK
  • Flag
  • His
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NFATC2-18H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFATC2-29251TH Recombinant Human NFATC2, His-tagged E.coli His
Human NFATC2-181H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFATC2-182H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFATC2-2740HFL Recombinant Full Length Human NFATC2 protein, Flag-tagged Mamanlian cells Flag
Human NFATC2-3619H Recombinant Human NFATC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NFATC2-391H Recombinant Human NFATC2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Nfatc2-4388M Recombinant Mouse Nfatc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NFATC2 Related Articles
  • NFATC2 Related Research Area
  • NFATC2 Related Signal Pathway

NFATC2 involved in several pathways and played different roles in them. We selected most pathways NFATC2 participated on our site, such as cGMP-PKG signaling pathway, Wnt signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayAKT1;CREB3L1;SLC25A31;RHOA;OPRD1;IRS4;PRKG2;INS1;NOS3
Wnt signaling pathwayMMP7;PPP3CA;FRAT2;CAMK2D1;FZD8A;MAPK8A;NLK1;RAC1A;RAC1
Axon guidanceSPRED1;PEA15;NFATC3;EPHA3;MYL12B;RAC3;SCN3A;ITGB3A;RGMA
VEGF signaling pathwayPRKCA;PLA2G4AA;PIK3R5;MAP2K2B;PTK2AA;NRAS;PPP3CCA;HSPB1;PXNA
Osteoclast differentiationFHL2;CYBB;MAP3K7;IL1B;TNFSF11;PIK3R3;LILRB3;FCGR3A;SYK
Natural killer cell mediated cytotoxicityHLA-A;PIK3R1;PIK3CA;PPP3R1;IFNGR1;NCR3;ICAM2;RAET1E;MICA
T cell receptor signaling pathwayPIK3CB;MUC1;IL4;CD8B;CDC42;AKT2;CBLC;PPP3R2;CBL
B cell receptor signaling pathwayPPP3CC;Cd79a, Cd79b;BCL2L11;CD72;SLA2;AKT1;VAV3;BLK;RELA
Oxytocin signaling pathwayPRKAA1;MAP2K2;OXT;MAPK1;RYR2;MAP2K5;MYLK;CACNA2D3;ACTB
Hepatitis BPIK3CG;IFNA10;IFNB1;GRB2;PTK2B;STAT3;PIK3R1;CCNA1;PCNA
HTLV-I infectionITGB2L;CREM;HLA-DPA1;PIK3R3;TRP53INP1;ATM;MYBL2;PDGFRA;XPO1

NFATC2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC2 itself. We selected most functions NFATC2 had, and list some proteins which have the same functions with NFATC2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTP53;SMAD3A;FOXF2;LHX2A;HIST1H1T;SIX1A;IRF7;POLR1D;ZNF461
RNA polymerase II core promoter proximal region sequence-specific DNA bindingETS2;CTCFL;GRHL1;PAXBP1;NOBOX;IFI16;NR2C1;ATF3;PAX8
chromatin bindingTCF7L2;ARX;NFKB1;FLI1;SOX15;FANCM;DNMT3A;ZKSCAN3;TRP63
protein bindingNUMB;MYRIP;CCDC101;MYO1C;IGFBP5;MGAT5B;C16orf53;CALB1;SIPA1L2
transcription factor activity, sequence-specific DNA bindingFOXQ1B;ZNF187;MNT;ZNF567;ZNF490;ARID4A;NFE2L1B;SIX4;ZNF192
transcription factor bindingMSX2;CCND1;TFDP1A;KAT2B;HEY1;HMGB2;MED12L;SIX2;DRG1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSIX4;FOXL2;HOXC13;ELK1;NR5A2;EBF4;NUCKS1;HMGA2;JUNB
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingSREBF2;ATF3;PITX2;GATA3;SFPI1;EN1;NEUROG3;AEBP2;ZBTB20

NFATC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC2.

VRK2; VRK2; arre2_element_mouse_il2_promoter; LRRK2; il2_human_gene; ccl5-derived_putative-nfat-site_dna-probe

Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
Drozdenko, G; Scheel, T; et al. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:364-372(2014).
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