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NFATC2

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

  • Overview

    The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an
  • Synonyms

    NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, cytoplasmic 2; NF ATP; NFAT1; NFATp; NF-ATc2; NFAT pre-existing subunit; T cell transcription factor NFAT1; T-cell transcription factor;

  • Recombinant Proteins
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • C
  • Myc
  • DDK
  • Flag
  • His
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NFATC2-18H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFATC2-29251TH Recombinant Human NFATC2, His-tagged E.coli His
Human NFATC2-181H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFATC2-182H Recombinant Human NFATC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NFATC2-2740HFL Recombinant Full Length Human NFATC2 protein, Flag-tagged Mamanlian cells Flag
Human NFATC2-3619H Recombinant Human NFATC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NFATC2-391H Recombinant Human NFATC2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Nfatc2-4388M Recombinant Mouse Nfatc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NFATC2 Related Articles
  • NFATC2 Related Research Area
  • NFATC2 Related Signal Pathway

NFATC2 involved in several pathways and played different roles in them. We selected most pathways NFATC2 participated on our site, such as cGMP-PKG signaling pathway, Wnt signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayKCNJ8;MAP2K1;ROCK2;PPIF;IRS4;MEF2A;VDAC3;OPRD1;VASP
Wnt signaling pathwayNFATC3;TBL1Y;TP53;TBL1XR1;FRAT2;FOSL1;WNT5A;ROCK2;APC
Axon guidanceRHOAE;CDK5R1B;DPYSL5A;SEMA6D;EPHA2;TRIO;CSNK2B;DPYSL3;EPHB4A
VEGF signaling pathwayPLA2G4D;MAPK12A;RAC3A;RAF1A;RAC2;HRASA;PIK3R5;PTK2AB;MAPK14A
Osteoclast differentiationIFNGR1;CYLD;IFNAR2;PIK3R1;LILRB4;TGFBR1;TNFRSF11A;MAPK10;TGFB1
Natural killer cell mediated cytotoxicityNFATC2;BRAF;PLCG2;PTK2B;IFNA12;IFNGR2;ZAP70;ULBP2;IFNA4
T cell receptor signaling pathwayLAT;SHB;MAP3K7;MAPK3;PDCD1;VAV1;NFKBIB;GSK3B;PDPK1
B cell receptor signaling pathwayPDK2B;GSK3B;CD81;CTNNB2;ARPC5;PPP3R1;CRKL;FCGR2B;PTPN18
Oxytocin signaling pathwayROCK2;PPP3CA;PLCB3;CACNB2;ACTG1;Adcy4;ELK1;MYLK3;MYL9
Hepatitis BPIK3R5;TBK1;FADD;STAT5A;DDX3X;NFATC2;FOS;PIK3CD;PRKCB
HTLV-I infectionMSX2;ITGB2L;HLA-DQA2;Il2;VAC14;BUB3;POLB;ATF4;FOSL1

NFATC2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC2 itself. We selected most functions NFATC2 had, and list some proteins which have the same functions with NFATC2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHOXD13A;PAX2A;THAP11;CENPW;HER6;POLR2H;ZNF223;HIST1H2AG;HDGF
RNA polymerase II core promoter proximal region sequence-specific DNA bindingETV6;H2AFZ;MYOD1;KLF17;CEBPB;DDIT3;AKNA;POU4F3;POU3F2
chromatin bindingSMARCD3;BAHD1;CDC45;CBX4;WHSC1;FOXO1;TOX4;SMARCD1;MLH3
protein bindingCCNDBP1;PXN;POLR2E;TRAF1;LAPTM4B;TPSB2;MEAF6;CDPF1;ZFYVE19
transcription factor activity, sequence-specific DNA bindingHSFY1;TSC22D4;SMAD3B;SIM2;NR3C1;BRD8;TCF7;ZSCAN4;CREB5
transcription factor bindingADD1;GATA3;YWHAZ;FOXO4;NLRP3;ZBTB49;KCNA3;MLXIPL;MAPK1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingARNT2;CARF;CTCFL;ZFAT;JUN;GATA3;HNF1A;FOSL1;POU2F2
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingZGPAT;IFI16;REST;ATF7;E2F8;BCL11AB;BATF3;NFIL3-5;NKX6

NFATC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC2.

VRK2; VRK2; arre2_element_mouse_il2_promoter; LRRK2; il2_human_gene; ccl5-derived_putative-nfat-site_dna-probe

Bonami, RH; Wolfle, WT; et al. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. MOLECULAR IMMUNOLOGY 62:321-328(2014).
Drozdenko, G; Scheel, T; et al. Impaired T cell activation and cytokine production by calcitriol-primed human B cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:364-372(2014).
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