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NFATC4

  • Official Full Name

    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

  • Overview

    This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Synonyms

    NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; NFAT3; NF-AT3; NF-ATC4; nuclear factor of activated T-cells, cytoplasmic 4; T-cell transcription factor NFAT3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NFATC4-1275H Recombinant Human NFATC4, GST-tagged E.coli GST 228-582aa
Human NFATC4-1188HCL Recombinant Human NFATC4 cell lysate N/A
Human NFATC4-750H Recombinant Human NFATC4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse NFATC4-10613M Recombinant Mouse NFATC4 Protein Mammalian Cell His
Mouse Nfatc4-4390M Recombinant Mouse Nfatc4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NFATC4-6031M Recombinant Mouse NFATC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NFATC4-6031M-B Recombinant Mouse NFATC4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NFATC4 Related Articles
  • NFATC4 Related Signal Pathway

NFATC4 involved in several pathways and played different roles in them. We selected most pathways NFATC4 participated on our site, such as cGMP-PKG signaling pathway, Wnt signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayCREB3L1;PPP3CC;NOS3;PPP3CA;GTF2I;PPP3R2;ATP1B2;MYLK;AGTR1A
Wnt signaling pathwayPLCB1;RAC1A;LRP5;FBXW2;NKD2;CUL1B;BAMBIB;PRKACAB;NLK
Axon guidanceLRRC4C;HRAS;CSF2RB;DUSP4;PLXND1;KIF4;MAPK3;NTN1;GFRA1
Oxytocin signaling pathwayPRKACG;CACNA2D1;PIK3CA;OXT;CACNG4;CACNB3;ROCK2;NOS3;PRKAG3
Hepatitis BFasl;TRP53;OSTN;FASLG;NRAS;TGFBR1;YWHAB;CCNE2;CCND1
HTLV-I infectionWNT2B;Pdgfa&Pdgfb;ITGAL;XIAP;POLB;HLA-F;FZD7;HLA-E;MAP3K1

NFATC4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, peroxisome proliferator activated receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC4 itself. We selected most functions NFATC4 had, and list some proteins which have the same functions with NFATC4. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingAKNA;CEBPE;NOBOX;RFX8;SIX2;ZNF92;ASCL1;HELT;SMAD4
peroxisome proliferator activated receptor bindingASXL1;PPARGC1A;HMGA1;CREBBP;ASXL2;IKBKG;EP300;NR0B2;MED1
protein bindingSGIP1;EYA4;NTF4;KPNB1;TEKT5;ANKS4B;TAL2;RHOC;UBE3A
transcription coactivator activityDDX5;TFAP2B;MKL1B;RNF20;SCAND1;NACA;THRAP3;MED14;PARK7
transcription factor bindingTRIB1;MYOCD;ATOH8;ENPP2;TFAP2A;PPARGC1A;NFATC2;PSMD10;CRY1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingTCF3;ZKSCAN3;PYDC3;NFATC2;ZFPM2;CTCF;BATF3;TBX15;PROX2

NFATC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC4.

UBC; Dlg4; PASK; MAPK14; NR1I2; JUP; CCNG1; GPR22; ANKRD28; YWHAQ

Petra, H; Eva, H; et al. Molecular Profiling of Acute and Chronic Rejections of Renal Allografts. CLINICAL & DEVELOPMENTAL IMMUNOLOGY :-(2013).
Minematsu, H; Shin, MJ; et al. Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages. CELLULAR SIGNALLING 23:1785-1793(2011).
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