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NFKBIE

Official Full Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Overview

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.
Synonyms

NFKBIE; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon; NF-kappa-B inhibitor epsilon; IKBE; ikB-E; ikB-epsilon; NF-kappa-BIE; ikappaBepsilon; I-kappa-B-epsilon;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NFKBIE-232H	Recombinant Human NFKBIE protein, His-tagged	E.coli	His		Inquiry
Human	NFKBIE-28876TH	Recombinant Human NFKBIE, His-tagged	E.coli	His		Inquiry
Human	NFKBIE-1283H	Recombinant Human NFKBIE, GST-tagged	E.coli	GST	C-term-361aa	$319 / 25ug
Human	NFKBIE-4697H	Recombinant Human NFKBIE Protein (Arg207-Pro440), N-His tagged	E.coli	N-His	Arg207-Pro440	Inquiry
Mouse	NFKBIE-10627M	Recombinant Mouse NFKBIE Protein	Mammalian Cell	His		Inquiry
Mouse	Nfkbie-1301M	Recombinant Mouse Nfkbie protein, His & T7-tagged	E.coli	His/T7	Ala115~Phe350 (Accession # O54910)	Inquiry
Mouse	NFKBIE-6042M	Recombinant Mouse NFKBIE Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	NFKBIE-6042M-B	Recombinant Mouse NFKBIE Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	NFKBIE-5017Z	Recombinant Zebrafish NFKBIE	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NFKBIE Related Articles

NFKBIE involved in several pathways and played different roles in them. We selected most pathways NFKBIE participated on our site, such as T cell receptor signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKBIE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
T cell receptor signaling pathway	GRAPA;CABIN1;HRAS;MAP2K7;MAP2K1;ZAP70;CD4;GRAP2;NFKB1
B cell receptor signaling pathway	LYN;RAP2A;NFATC1;MAP4K1;IGHM;SYK;ACTR3;BLK;BTK
Neurotrophin signaling pathway	ARHGDIG;RAP1A;MAPK12;CALM4;RAF1;CAMK2A;MAPK11;PSEN1;GSK3B
Adipocytokine signaling pathway	CAMKK1A;NFKBIB;CAMKK2;LEP;MAPK9;SLC2A1;CD36;PPARAB;ADIPOR1B
Epstein-Barr virus infection	MDM2;HLA-B;POLR1D;POLR2J;PSMC1;RBPJ;TBK1;RAN;POLR2A

NFKBIE has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKBIE itself. We selected most functions NFKBIE had, and list some proteins which have the same functions with NFKBIE. You can find most of the proteins on our site.

Function	Related Protein
protein binding	PIAS1;ATG5;SFRP5;PSMA1;ATP1A2;CDK8;TUBB2A;DRAM1;GNB2L1

NFKBIE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKBIE here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKBIE.

PPP6R2; PPP6R1; C1QBP; ANKHD1; RELA; NFKB2; ebi-359405; PPP6C; ANKRD28; CHUK; ANKRD17; BAG2; TUBB4A

Suzuki, T; Ikari, K; et al. PADI4 and HLA-DRB1 Are Genetic Risks for Radiographic Progression in RA Patients, Independent of ACPA Status: Results from the IORRA Cohort Study. PLOS ONE 8:-(2013).