nfyb
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  • Official Full Name
  • nuclear transcription factor Y, beta
  • Background
  • Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene. The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.
  • Synonyms
  • NFYB; nuclear transcription factor Y, beta; HAP3; CBF-A; CBF-B; NF-YB; nuclear transcription factor Y subunit beta; Transcription; factor NF-Y, B subunit; CAAT box DNA-binding protein subunit B; nuclear transcription factor Y subunit B; CCAAT-binding transcription factor subunit A
Cat.#:NFYB-29919THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFYB
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Cat.#:NFYB-10635MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NFYB Protein
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Cat.#:NFYB-3978RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NFYB Protein
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Cat.#:NFYB-3020RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NFYB Protein, His-tagged
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Cat.#:NFYB-6821CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NFYB
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Cat.#:NFYB-3839HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NFYB 293 Cell Lysate
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Involved Pathway

NFYB involved in several pathways and played different roles in them. We selected most pathways NFYB participated on our site, such as Antigen processing and presentation, Tuberculosis, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFYB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
HLA-DRB5; HLA-DRB1; TAPBP; HLA-DQB1; CD8A; KLRC2; HLA-E; HLA-DRB3; KIR2DL1; HLA-B
Tuberculosis
IFNA4; BID; ATP6V1H; IFNA12; PLK3; ITGB2L; KSR1; Cd209g; LSP1; ATP6V0B
HTLV-I infection
HLA-DQA2; VDAC2; HLA-B; TSPO; NFYB; SPI1; TNFRSF13C; PIK3R2; HLA-DRA; TP53

Protein Function

NFYB has several biochemical functions, for example, DNA binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFYB itself. We selected most functions NFYB had, and list some proteins which have the same functions with NFYB. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein LCORL; TCEA1; NR1D4A; GTF2I; HIST1H2AE; PRM3; DDX3X; ANG3; PARP1; HLX1
Function protein binding
Related Protein PDIA3; NOTCH4; ZNF514; HSD17B14; FGF1; ADD1; XAB2; ARF6; SLA2; CMKLR1
Function protein complex binding
Related Protein MAPK8IP2; PTK2B; VAMP2; BAX; SLC9A3R1; NCKAP1; PAFAH1B1; PTCH1; SLC25A3; DRD1A
Function protein heterodimerization activity
Related Protein MAFGB; SIM2; CEBPB; SYCP2; ODZ4; ITGA3; HIST1H4A; INHBA; MAPK4; HIST1H2BB
Function repressing transcription factor binding
Related Protein GMNN; HDAC1; MAGEA2; HDAC9; HDAC7; KAT5; SRI; HDAC4; TLE4; EIF4E
Function sequence-specific DNA binding
Related Protein CREBZF; RORCB; NKX3.2; HOXA5A; GATAD1; LHX2B; CTCFL; HLFA; FOXO3B; USF1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ATOH1; PAX7; TRP53; MESPBA; ZNF7; ELF2A; HINFP; HSFX1; ZSCAN12; KDM5A
Function contributes_to transcription regulatory region DNA binding
Related Protein RXRA; NFYA; TCF3; ATF4; TCF12; NR1H3; TAF1; HDAC5; HDAC4; NFYC

Interacting Protein

NFYB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFYB here. Most of them are supplied by our site. Hope this information will be useful for your research of NFYB.
NFYA; NFYC; DRAP1; TP53