nfyb
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  • Official Full Name
  • nuclear transcription factor Y, beta
  • Background
  • Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene. The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.
  • Synonyms
  • NFYB; nuclear transcription factor Y, beta; HAP3; CBF-A; CBF-B; NF-YB; nuclear transcription factor Y subunit beta; Transcription; factor NF-Y, B subunit; CAAT box DNA-binding protein subunit B; nuclear transcription factor Y subunit B; CCAAT-binding transcription factor subunit A
Cat.#:NFYB-2134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFYB Protein (1-207 aa), GST-tagged
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Cat.#:NFYB-29919THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFYB
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Cat.#:NFYB-10635MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NFYB Protein
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Cat.#:NFYB-3978RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NFYB Protein
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Cat.#:NFYB-3020RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NFYB Protein, His-tagged
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Cat.#:NFYB-6821CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NFYB
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Cat.#:NFYB-3839HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NFYB 293 Cell Lysate
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Involved Pathway

NFYB involved in several pathways and played different roles in them. We selected most pathways NFYB participated on our site, such as Antigen processing and presentation, Tuberculosis, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFYB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
HSPA1A; KLRD1; KIR2DS5; CALR; HLA-DRA; KLRC2; HLA-F; TAPBP; HSP90AA1; CD8B1
Tuberculosis
ATP6V1H; ITGB2; FCGR3; LSP1; MRC1; SYK; TNFRSF1A; PPP3CC; IL10RA; CALML5
HTLV-I infection
CDC20; CANX; TGFBR2; IL1R2; VCAM1; WNT7B; PPP3R1; PIK3R2; STAT5A; TBP

Protein Function

NFYB has several biochemical functions, for example, DNA binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFYB itself. We selected most functions NFYB had, and list some proteins which have the same functions with NFYB. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF354A; HOXD4A; PPARGC1A; SOX1B; ZNF446; HIST2H2L; MLL1; ZNF71; NEUROG1; E2F4
Function protein binding
Related Protein OTUD7B; LIN7A; PTK7; CLK3; C9orf142; ZNF212; PDE4DIP; CACNG1; HIST1H4K; TRIM29
Function protein complex binding
Related Protein FBN1; NCKAP1L; ADRB2; CPD; GIT1; CCND1; ERCC8; Casp3; HTR2A; MLKL
Function protein heterodimerization activity
Related Protein CYBA; UGT1A7; BCL2L10; SMC4; SOS1; NOTCH4; HER1; PRMT8; HIST1H2AL; NKX2
Function repressing transcription factor binding
Related Protein TCF3; GMNN; PRDM5; TLE4; RELA; SRI; DDX20; SKI; HDAC7; CTBP1
Function sequence-specific DNA binding
Related Protein HOXC10; TEF; LHX3; ATF7; TRP53; PAX7B; IRF4; ENG2B; DLX6A; GATA1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein GLIS2; SIN3A; ZSCAN4C; HOXB8B; ATF4B1; SALL2; ZNF227; NFYA; CREBL2; DMRTA2
Function contributes_to transcription regulatory region DNA binding
Related Protein TCF3; RXRA; NR1H3; TAF1; NFYA; HDAC4; ATF4; TCF12; HDAC5; NFYC

Interacting Protein

NFYB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFYB here. Most of them are supplied by our site. Hope this information will be useful for your research of NFYB.
NFYA; NFYC; DRAP1; TP53