nfyc
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  • Official Full Name
  • nuclear transcription factor Y, gamma
  • Background
  • This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NFYC; nuclear transcription factor Y, gamma; nuclear transcription factor Y subunit gamma; CBF C; NF YC; transactivator HSM-1; transactivator HSM-1/2; CCAAT binding factor subunit C; transcription factor NF-Y, C subunit; CAAT box DNA-binding protein subun
Cat.#:NFYC-308HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFYC Protein, His/GST-tagged
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Cat.#:NFYC-29920THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NFYC
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Cat.#:NFYC-3979RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NFYC Protein
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Cat.#:NFYC-10040ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NFYC
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Cat.#:NFYC-3838HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NFYC 293 Cell Lysate
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Involved Pathway

NFYC involved in several pathways and played different roles in them. We selected most pathways NFYC participated on our site, such as Antigen processing and presentation, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFYC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
HLA-C; PDIA3; HLA-DMA; H2-AA; HSPA5; HLA-G; PSME2; HSPA1B; TAP1; RFXANK
Tuberculosis
PPP3CB; HLA-DOA; NFYB; HLA-DQA1; NFYC; FCER1G; LAMP1; SRC; IRAK1; Casp3

Protein Function

NFYC has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFYC itself. We selected most functions NFYC had, and list some proteins which have the same functions with NFYC. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NKX6.1; RORCA; PAX4; FLI1A; TBL1XR1; SUB1A; ZFP574; PARPBP; PCGF2; FOXB1B
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein PYDC3; DDN; GMEB1; OVOL1; ETV6; MESP1; NEUROG3; HOXA2; PDX1; NR4A3
Function protein binding
Related Protein CHMP1B; AGBL1; CTNNBIP1; MAB21L2; SLU7; TPM1; ZNF238; C1orf105; RPS6; HSFX1
Function protein heterodimerization activity
Related Protein ADD2; CENPA; TERF1; MAFA; MCL1A; SNX5; TENM2; LIMK2; HIST1H4B; Itgam&Itgb2
Function transcription coactivator activity
Related Protein PCBD1; MAK; MED21; ABT1; YAF2; RUNX1; NFKBIB; MED23; PER2; APEX1
Function transcription factor activity, sequence-specific DNA binding
Related Protein RBPJ; HIC1; HOXB5A; SPI1; HIF1AL; TEAD2; NR4A2B; MYCLB; ZFP2; ZNF436
Function transcription factor binding
Related Protein BCL10; PSMD10; PARK7; TRIB2; GTF2A2; HEY2; HMGA1; PPRC1; PIM1; DACT2
Function contributes_to transcription regulatory region DNA binding
Related Protein HAND1; NR1H3; NFYC; HDAC5; TAF1; TCF3; ATF4; TCF12; NFYA; NFYB
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein HMGA2; TFE3; EBF1; EGR1; HOXA5; KLF4; MEF2C; NKX2-5; TRP53; TFE3A

Interacting Protein

NFYC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFYC here. Most of them are supplied by our site. Hope this information will be useful for your research of NFYC.
NFYB; NFYA; SNX2; GAPDH; CSN2; SP1; ATF6; LMO4; DR1; DST; SREBF2; bipA; ARID2; KIAA2018

NFYC Related Articles

Tremblay, AM; Wilson, BJ; et al. Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif. MOLECULAR ENDOCRINOLOGY 22:570-584(2008).
Vila-Del Sol, V; Diaz-Munoz, MD; et al. Requirement of tumor necrosis factor at and nuclear factor-kappa B in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages. JOURNAL OF LEUKOCYTE BIOLOGY 81:272-283(2007).