nkx2-5
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  • Official Full Name
  • NK2 homeobox 5
  • Background
  • This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • NKX2-5; NK2 homeobox 5; CSX; CSX1; VSD3; CHNG5; HLHS2; NKX2E; NKX2.5; NKX4-1; homeobox protein Nkx-2.5; tinman paralog; homeobox protein CSX; cardiac-specific homeobox 1; homeobox protein NK-2 homolog E; NK2 transcription factor related, locus 5;
Cat.#:NKX2-5-5900HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NKX2-5 Protein, GST-tagged
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Cat.#:NKX2-5-10700MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NKX2-5 Protein
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Cat.#:NKX2-5-3993RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NKX2-5 Protein
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Cat.#:NKX2-5-6720CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NKX2-5
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Cat.#:NKX2-5-439HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human NKX2-5 lysate
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Involved Pathway

NKX2-5 involved in several pathways and played different roles in them. We selected most pathways NKX2-5 participated on our site, such as Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX2-5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Heart Development
NKX2-5; GATA6; NKX2; BMP10; TBX20; FOXC2; TBX5; IRX4; HEY2; HEY1

Protein Function

NKX2-5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX2-5 itself. We selected most functions NKX2-5 had, and list some proteins which have the same functions with NKX2-5. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein MLLT10; DDB1; MSXB; OTUD7B; POLRMT; TAL2; YEATS4; ZFP39; TSHZ3; ZNF785
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein MYF5; SIX2; RFX5; TCF12; NRF1; AEBP2; JUND; CEBPZ; NFAT5; ZFP746
Function RNA polymerase II transcription cofactor activity
Related Protein TDG; MED31; MDT-19; MED17; MED10; MED18; MED13L; MED13B; MED26; THRAP3
Function chromatin binding
Related Protein EZH1; GLI3; MLL1; SUZ12; RBPJ; PBRM1; EP300; HESX1; BAP1; RNF20
Function histone deacetylase binding
Related Protein KLF4; BRMS1L; KPNA2; FOXP3; MEF2B; CEBPA; SOD3; GCM1; SP2; NACC2
Function protein binding
Related Protein KEAP1; PCGF2; CCHCR1; NUP155; SEMA3E; RPL11; SERPINA3K; CD200R2; UPP2; STARD13
Function protein heterodimerization activity
Related Protein TENM3; XBP1; TAF4B; HER11; ATF2; HOMER1; NPM1; USF2; TLX1; EXT2
Function protein homodimerization activity
Related Protein BAK1; DMRTC2; CRYBA1; CARD8; FLNA; SYT16; HPGD; PRDM6; SDCBP2; ABCD2
Function sequence-specific DNA binding
Related Protein NR4A1; NFYB; ZFP536; DBX2; LHX2; PAX6B; EDF1; IRX5; FOXH1; NFIL3-4
Function serum response element binding
Related Protein SRF; NKX2; NKX2-5
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein SFPI1; HNF1B; SNAI2; FOXF1; MEF2A; TLE4; PROX1; MYF5; PKNOX1; T
Function transcription factor activity, sequence-specific DNA binding
Related Protein HOXC6B; DMRTC1C2; FOXC1B; FOXS1; RORAB; DBPB; HOXA13; POU3F4; IKZF4; HMGB2
Function contributes_to transcription factor activity, sequence-specific DNA binding
Related Protein VDRA; TAF6; TAF12; MAFGA; GATA4; TAF7; TRIM28; RXRA; MAFGB; SOX1A
Function transcription factor binding
Related Protein BPTF; ETS1; CXXC5; RORA; E2F2; CEBPB; MDFI; KAT6B; HES3; SRY
Function transcription regulatory region DNA binding
Related Protein CREB3L2; NFE2L2; NKX3; PHB; CDK9; IKZF1; HNRNPL; SREBF1; NR1D1; CDK5RAP2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein ETV2; ESRRA; HNRNPK; MESP1; TTC6; POU3F2; TFAP2B; FUBP3; SMAD1; MITF
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein PITX1; NR1H4; FOXH1; NKX2-5; KLF4; CLOCK; KLF14; SOX10; MIXL1; WWP2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ONECUT3; CREB3L3; CSRNP2; MAFGA; ATF2; ATF5; HOXD8; GATA6; BARX2; CEBPA

Interacting Protein

NKX2-5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX2-5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX2-5.
Gata4; Jarid2; CAMTA2; TBX5; anf_rat_gene

NKX2-5 Related Articles

Nan, CL; Dube, S; et al. Expression of Sarcomeric Tropomyosin in Striated Muscles in Axolotl Treated with Shz-1, a Small Cardiogenic Molecule. CARDIOVASCULAR TOXICOLOGY 15:29-40(2015).
Sandstedt, J; Jonsson, M; et al. SSEA-4+CD34-Cells in the Adult Human Heart Show the Molecular Characteristics of a Novel Cardiomyocyte Progenitor Population. CELLS TISSUES ORGANS 199:103-116(2014).