NKX2-5
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Official Full Name
NK2 homeobox 5
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Overview
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] -
Synonyms
NKX2-5; NK2 homeobox 5; CSX; CSX1; VSD3; CHNG5; HLHS2; NKX2E; NKX2.5; NKX4-1; homeobox protein Nkx-2.5; tinman paralog; homeobox protein CSX; cardiac-specific homeobox 1; homeobox protein NK-2 homolog E; NK2 transcription factor related, locus 5;
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- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- NKX2-5 Related Articles
NKX2-5 involved in several pathways and played different roles in them. We selected most pathways NKX2-5 participated on our site, such as Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX2-5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Heart Development | NKX2-5;BMP10;FOXC2;TBX5;TBX20;FOXH1;FOXC1;SMYD1;GATA6 |
NKX2-5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX2-5 itself. We selected most functions NKX2-5 had, and list some proteins which have the same functions with NKX2-5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZC3H3;PCBP3;GFI1B;HOMEZB;FOXD5;ZNF582;ZNF446;SIX3B;POU3F3B |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NEUROD6;ELK3;FUBP3;BCL11A;NFIB;HOXA2;NFATC2;PRDM1;FOXJ1 |
| RNA polymerase II transcription cofactor activity | PPARGC1A;MED19;NKX2;MED1;THRAP3;CNOT2;MED13A;MED7;TP53BP1 |
| chromatin binding | RBPJ;MEIS1;OVOL2;HMGXB4;CCDC111;SIX1;ISL1;TRP63;WDR82 |
| histone deacetylase binding | CCND1;MAGEA1;HIC1;NKX3;CDC20;HDAC5;MAGEA2;ZNF703;MEF2B |
| protein binding | CNTROB;ARHGEF7;ABCG1;PIK3R4;PEX5;CABP1;COLQ;TRAPPC5;TRIM28 |
| protein heterodimerization activity | RARA;PKNOX1;JAM3;KCNK9;OSTA;TXLNG;PVALB;TAF6L;TAF13 |
| protein homodimerization activity | UGT1A3;FGFR1;ACTN4;FBXO4;PRTFDC1;IL17F;FASN;MCL1;PDCD6IP |
| sequence-specific DNA binding | EN2;ZFP536;PRRXL1;HOXA13A;NKX6.3;UBP1;TFAP4;LHX8A;MAFG |
| serum response element binding | SRF;NKX2-5;NKX2 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | MEIS1;NFATC1;ZFHX3;PKNOX1;SOX9;SPI1;AHR;SFPI1;RFX3 |
| transcription factor activity, sequence-specific DNA binding | BSX;ZNF263;ZNF217;ASCL1;PPARG;ZFP354A;SIM1B;FOSL1A;ATF6B |
| contributes_to transcription factor activity, sequence-specific DNA binding | NFE2L2A;NKX2-5;HNRNPAB;TAF12;GATA4;SMAD2;MAFGA;TAF10;SOX19A |
| transcription factor binding | KEAP1B;UBE2I;ETS1;STK36;PPP1R13BB;HHEX;HOXA7;KDM1A;TFDP1A |
| transcription regulatory region DNA binding | ZNF217;TCF7L1A;BCOR;SMAD4;FOXC2;TP73;ATF6B;NKX2-5;NR1D1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOXJ1;GLI3;ELK3;NFIC;ATF4;SOX11;ONECUT3;YBX1;ATOH1 |
| transcriptional activator activity, RNA polymerase II transcription factor binding | NKX2-5;WWP2;SOX10;CREB1;NKX2;LMO2;PPARA;FOXH1;KLF4 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | SLAMF7;LMO2;GATA3;BARHL1A;SOX17;CSRNP1;STAG2;REST;MAFG |
NKX2-5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX2-5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX2-5.
Gata4; Jarid2; CAMTA2; TBX5; anf_rat_gene
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