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NKX3-1

  • Official Full Name

    NK3 homeobox 1

  • Overview

    The Nkx3.1 gene is an androgen regulated prostate-specific homeobox gene, located on chromosome 8p21. In mice the homologue Nkx3.1 is exclusively expressed in prostate epithelium. In humans, Nkx3.1 expression is also restricted to the prostate. Many data show that Nkx3.1 expression is highly, but not exclusively, specific for the prostate.
  • Synonyms

    NKX3-1; NK3 homeobox 1; NK homeobox (Drosophila), family 3, A , NK3 transcription factor related, locus 1 (Drosophila) , NKX3A; homeobox protein Nkx-3.1; BAPX2; NKX3.1; NK homeobox, family 3, A; homeobox protein NK-3 homolog A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3; NKX3A;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NKX3-1-7100H Recombinant Human NKX3-1, His-tagged E.coli His 1-234aa
Human NKX3-1-28096TH Recombinant Human NKX3-1 Wheat Germ N/A 110 amino acids
Human NKX3-1-1305H Recombinant Human NKX3-1, GST-tagged E.coli GST 125-181aa
Human NKX3-1-5903H Recombinant Human NKX3-1 Protein, GST-tagged Wheat Germ GST
Human NKX3-1-6706HF Recombinant Full Length Human NKX3-1 Protein, GST-tagged In Vitro Cell Free System GST 234 amino acids
Human NKX3-1-469H Recombinant Human NKX3-1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse NKX3-1-10703M Recombinant Mouse NKX3-1 Protein Mammalian Cell His
Mouse Nkx3-1-4427M Recombinant Mouse Nkx3-1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NKX3-1-6087M Recombinant Mouse NKX3-1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NKX3-1-6087M-B Recombinant Mouse NKX3-1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NKX3-1-3037R Recombinant Rhesus monkey NKX3-1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NKX3-1-2856R Recombinant Rhesus Macaque NKX3-1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NKX3-1-2856R-B Recombinant Rhesus Macaque NKX3-1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NKX3-1 Related Articles
  • NKX3-1 Related Research Area

NKX3-1 involved in several pathways and played different roles in them. We selected most pathways NKX3-1 participated on our site, such as Pathways in cancer, Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX3-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerPRKACA;BIRC2;FGF11;GNAI3;FZD1;VEGFA;PIK3R3;PTCH1;ITGA2
Prostate cancerTCF7L2;HSP90AA1;Ar;IGF1;Pdgfa&Pdgfb;MAP2K2;AKT1;ARID1A;NOXA1

NKX3-1 has several biochemical functions, for example, DNA binding, MADS box domain binding, androgen receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX3-1 itself. We selected most functions NKX3-1 had, and list some proteins which have the same functions with NKX3-1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPCXA;ASH1L;ZFAT;ZSCAN4C;ZKSCAN5;MYCB;CDX1B;FAM170A;ZNF436
MADS box domain bindingNKX3-1;NKX3
androgen receptor activityNKX3-1;NR1I3;Ar;NKX3
core promoter bindingHNRNPU;KLF4;IFI203;GATA1;ELK4;NKX3-1;E2F7;ELK1;CALCOCO1
contributes_to cysteine-type endopeptidase activator activity involved in apoptotic processNKX3;NKX3-1;CDKN1B
estrogen receptor activityNKX3;ESR1;LEF1;ESR2B;NKX3-1;GPR30;ESR2A;ESR2
estrogen receptor bindingCNOT1;PCNA;STRN;FOXL2;ISL1;PPARG;DYX1C1;PPID;MED1
histone deacetylase bindingNKX2-5;SOD3;PKN2;PKN1;KLF4;DNMT3B;CCND1;ZNHIT1;CAMTA2
protein bindingPER2;MED19;RFC3;UTP14A;LAT2;CCDC116;GTF2H2;MORF4L1;TSSK4
protein kinase activator activityMARK2;FGF13;STRADA;NKX3;DUSP19;GPRC5B;TOM1L1;DAXX;NCKAP1L
protein self-associationSYP;NKX3;TMEM43;SLC9A3R1;ABCD3;SLC2A1;TNFAIP3;LDB1;NKX3-1
sequence-specific DNA bindingFOXI3B;ETV5B;GRHL2A;RX3;VDRA;LHX1B;OTX1A;NKX6.1;HOXA1A
contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specificNKX3-1;SRF
transcription factor activity, sequence-specific DNA bindingGABPA;DRAP1;BACH1;FOSL1;ARNT;ZNF23;CSRNP2;POU4F2;ZNF227
transcription factor bindingBRD7;TBX5;JUND;NAB1;HEY2;RBFOX2;CHCHD2;CREBBP;DR1
transcription regulatory region DNA bindingTBX21;SALL4;PAX8;MEF2C;EGR2;KCNA3;TFAP2A;TBL1X;ZNF567
transcription regulatory region sequence-specific DNA bindingBAHD1;SUV39H2;SOX2;HIF1AL;KDM3A;SOX4;KCNA3;NONO;PITX2

NKX3-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX3-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX3-1.

Mohanty, SK; Smith, SC; et al. Evaluation of Contemporary Prostate and Urothelial Lineage Biomarkers in a Consecutive Cohort of Poorly Differentiated Bladder Neck Carcinomas. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 142:173-183(2014).
Epstein, JI; Egevad, L; et al. Best Practices Recommendations in the Application of Immunohistochemistry in the Prostate Report From the International Society of Urologic Pathology Consensus Conference. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:E6-E19(2014).
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