nkx6-1
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  • Official Full Name
  • NK6 homeobox 1
  • Background
  • In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
  • Synonyms
Cat.#:NKX6-1-567HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NKX6-1 Protein, His/GST-tagged
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Cat.#:NKX6-1-5905HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NKX6-1 Protein, GST-tagged
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Cat.#:NKX6-1-600HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NKX6-1
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Cat.#:NKX6-1-10704MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NKX6-1 Protein
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Cat.#:NKX6-1-3994RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NKX6-1 Protein
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Involved Pathway

NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Maturity onset diabetes of the young
FOXA2; PDX1; MNX1; PKLR; HNF1B; PAX4; RFX6; HNF4G; NKX6-1; ONECUT1

Protein Function

NKX6-1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NUFIP1; ZFP335; ARHGEF38; DNASE2; H1FNT; FOXN1; C19orf40; KDM2BA; RORC; POU5F2
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TFAP2A; TGIF1; ETV1; MYOG; NFE2L3; MXD1; NOBOX; ZNF395; BATF2; E2F4
Function chromatin binding
Related Protein TCF7L1A; SLC30A9; ATOH1A; DLX2; DNAJC2; ZFP932; JARID2B; STAG2; TTC5; ASF1A
Function sequence-specific DNA binding
Related Protein INSM1A; MNX2B; ELF2B; IRX2A; LHX9; ENG1B; VSX1; DHARMA; ZNF232; ZNF238
Function transcription factor activity, sequence-specific DNA binding
Related Protein POU2F2; FOXQ1A; ZNF45; SALL3; ZHX1; NR1D1; POU2F1; HOXA5A; MYOG; TULP4
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein ZFP746; SKIL; GATA3; HINFP; NFATC2; RELA; NFE2L3; NFIL3-4; BCL11AB; TBX3

NKX6-1 Related Articles

Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).