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NKX6-1

  • Official Full Name

    NK6 homeobox 1

  • Overview

    In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N
  • GST,C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NKX6-1-600H Recombinant Human NKX6-1 Mammalian Cell His
Human NKX6-1-5905H Recombinant Human NKX6-1 Protein, GST-tagged Wheat Germ GST
Human NKX6-1-567H Recombinant Human NKX6-1 Protein, His/GST-tagged E.coli His/GST Met1~Ser367
Human NKX6-1-6707HF Recombinant Full Length Human NKX6-1 Protein, GST-tagged In Vitro Cell Free System GST 367 amino acids
Human NKX6-1-12HFL Recombinant Full Length Human NKX6-1 Protein, N-GST,C-His-tagged E. coli N-GST,C-His
Human NKX6-1-3631H Recombinant Human NKX6-1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NKX6-1-3631H-B Recombinant Human NKX6-1 Protein Pre-coupled Magnetic Beads HEK293
Human NKX6-1-4705H Recombinant Human NKX6-1 Protein (Met1-Ser367), N-GST tagged E.coli N-GST Met1-Ser367
Mouse NKX6-1-10704M Recombinant Mouse NKX6-1 Protein Mammalian Cell His
Mouse NKX6-1-6088M-B Recombinant Mouse NKX6-1 Protein Pre-coupled Magnetic Beads HEK293
Mouse NKX6-1-6088M Recombinant Mouse NKX6-1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NKX6-1-3994R Recombinant Rat NKX6-1 Protein Mammalian Cell His
Rat NKX6-1-3653R Recombinant Rat NKX6-1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NKX6-1-3653R-B Recombinant Rat NKX6-1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NKX6-1 Related Articles

NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Maturity onset diabetes of the youngONECUT1;MAFA;BHLHA15;MNX1;INS1;HNF1B;PAX6;HNF4G;SLC2A2

NKX6-1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingIRX3B;ZFP335;POU2F1A;NKX1.2LA;GSX1;DUX3;LASS2;VDRB;RUNX1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingPPARA;ISL1;ZNF217;MZF1;CDX4;H2AFZ;SIX2;Ar;ELK3
chromatin bindingPKN1;PYGO2;TADA2B;SOX10;UBE2T;MEF2C;DNMT1;NAP1L2;ATXN7
sequence-specific DNA bindingZNF831;POU2F1B;ATF5A;FOXO1B;NR1H3;EVE1;HIVEP2A;MKX;NR0B1
transcription factor activity, sequence-specific DNA bindingSOX13;RNF4;ZFP518A;POUV;ZSCAN23;HOXB6;DMRT3;CEBPD;HES1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingETS2;ASCL2;HELT;MLXIPL;NFATC4;KLF17;SALL1;CC2D1B;GZF1

NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.

Hald, J; Galbo, T; et al. Pancreatic islet and progenitor cell surface markers with cell sorting potential. DIABETOLOGIA 55:154-165(2012).
Conrad, R; Jablonka, S; et al. Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2011).
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