NKX6-1
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Official Full Name
NK6 homeobox 1
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Overview
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription;regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) (PubMed;15056733).
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- N
- GST,C
- Involved Pathway
- Protein Function
- Interacting Protein
- NKX6-1 Related Articles
NKX6-1 involved in several pathways and played different roles in them. We selected most pathways NKX6-1 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX6-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Maturity onset diabetes of the young | ONECUT1;MAFA;BHLHA15;MNX1;INS1;HNF1B;PAX6;HNF4G;SLC2A2 |
NKX6-1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX6-1 itself. We selected most functions NKX6-1 had, and list some proteins which have the same functions with NKX6-1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | IRX3B;ZFP335;POU2F1A;NKX1.2LA;GSX1;DUX3;LASS2;VDRB;RUNX1 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | PPARA;ISL1;ZNF217;MZF1;CDX4;H2AFZ;SIX2;Ar;ELK3 |
chromatin binding | PKN1;PYGO2;TADA2B;SOX10;UBE2T;MEF2C;DNMT1;NAP1L2;ATXN7 |
sequence-specific DNA binding | ZNF831;POU2F1B;ATF5A;FOXO1B;NR1H3;EVE1;HIVEP2A;MKX;NR0B1 |
transcription factor activity, sequence-specific DNA binding | SOX13;RNF4;ZFP518A;POUV;ZSCAN23;HOXB6;DMRT3;CEBPD;HES1 |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ETS2;ASCL2;HELT;MLXIPL;NFATC4;KLF17;SALL1;CC2D1B;GZF1 |
NKX6-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX6-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX6-1.
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