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NLRC4

  • Official Full Name

    NLR family, CARD domain containing 4

  • Overview

    In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
  • Synonyms

    NLRC4; NLR family, CARD domain containing 4; CARD12, caspase recruitment domain family, member 12; NLR family CARD domain-containing protein 4; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; ipaf; NOD like receptor C4; nucleotide binding oligomerizatio;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NLRC4-815H Recombinant Human NLRC4 Mammalian Cell His
Human NLRC4-1317H Recombinant Human NLRC4 Protein, GST-Tagged Wheat Germ GST
Human NLRC4-3805HCL Recombinant Human NLRC4 293 Cell Lysate HEK293 N/A
Human NLRC4-3639H Recombinant Human NLRC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NLRC4-3639H-B Recombinant Human NLRC4 Protein Pre-coupled Magnetic Beads HEK293
Mouse NLRC4-10714M Recombinant Mouse NLRC4 Protein Mammalian Cell His
Mouse NLRC4-6093M-B Recombinant Mouse NLRC4 Protein Pre-coupled Magnetic Beads HEK293
Mouse NLRC4-6093M Recombinant Mouse NLRC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NLRC4 Related Articles
  • NLRC4 Related Research Area

NLRC4 involved in several pathways and played different roles in them. We selected most pathways NLRC4 participated on our site, such as NOD-like receptor signaling pathway, Salmonella infection, Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NOD-like receptor signaling pathwayMAPK14A;HSP90AA1.1;NFKBIAB;NFKBIA;PSTPIP1A;ERBB2IP;CASP8;MAPK10;IL-8
Salmonella infectionNOS2B;MAPK12B;CXCL8B.3;WASF1;LBP;RILP;RHOGC;PKN1;TLR4BB
LegionellosisEEF1A2;SAR1A;PYCARD;NFKB1;CASP9;RAB1;IL6;IL-8;NLRC4

NLRC4 has several biochemical functions, for example, ATP binding, cysteine-type endopeptidase inhibitor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRC4 itself. We selected most functions NLRC4 had, and list some proteins which have the same functions with NLRC4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingAdcy4;CAMKV;EPHA4A;SYN1;MYH15;MYO5C;PLK2B;TWF1;LIG3
cysteine-type endopeptidase inhibitor activityKNG1;CARD18;AHSG1;FETUB;CST4;NLRC4;BIRC5A;CST14B.1;CST3
identical protein bindingPITX2;ACTN2;MNS1;ENTPD2;GUCY2E;GNPNAT1;VIL1;AMOTL2;ADIPOQ
magnesium ion bindingMTPAP;MARK1;DOM3Z;DYRK3;PIF1;PPM1A;IDH1;WEE2;IMPA2
protein bindingGPRC5A;THG1L;NPBWR2;SRP14;SEMG2;HSPB9;BAZ2B;RAD21;FAM127A
protein homodimerization activityCISD2;DMRT3A;ADRB2;HELT;RAB11FIP2;NAGA;PPP2R4;MID2;PTPRO
ubiquitin-protein transferase activityRNF220;UBE2W;RNF144AB;HECW1B;SMURF2;PEX12;MIB1;ZFP91;UBR1

NLRC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRC4.

CASP1; PYCARD; CASP8

Lockner, JW; Eubanks, LM; et al. Flagellin as Carrier and Adjuvant in Cocaine Vaccine Development. MOLECULAR PHARMACEUTICS 12:653-662(2015).
Lopez-Yglesias, AH; Zhao, X; et al. Flagellin Induces Antibody Responses through a TLR5-and Inflammasome-Independent Pathway. JOURNAL OF IMMUNOLOGY 192:1587-1596(2014).
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