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NLRP2

  • Official Full Name

    NLR family, pyrin domain containing 2

  • Overview

    NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in;the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be;involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 (PubMed;12563287)).
  • Synonyms

    NLRP2; NLR family, pyrin domain containing 2; NACHT, leucine rich repeat and PYD containing 2 , NALP2; NACHT, LRR and PYD domains-containing protein 2; CLR19.9; FLJ20510; NBS1; nucleotide binding oligomerization domain; leucine rich repeat and pyrin domai;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NLRP2-3800HCL Recombinant Human NLRP2 293 Cell Lysate HEK293 N/A
Human NLRP2-6755HF Recombinant Full Length Human NLRP2 Protein, GST-tagged In Vitro Cell Free System GST 846 amino acids
Human NLRP2-179H Recombinant Human NLRP2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human NLRP2-5921H Recombinant Human NLRP2 Protein, GST-tagged Wheat Germ GST
Human NLRP2-3681H Recombinant Human NLRP2 protein, His-tagged E.coli His 1-350 aa
Human NLRP2-36H Recombinant Human NLRP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Rhesus Macaque NLRP2-3046R Recombinant Rhesus monkey NLRP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NLRP2-2865R-B Recombinant Rhesus Macaque NLRP2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NLRP2-2865R Recombinant Rhesus Macaque NLRP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NLRP2 involved in several pathways and played different roles in them. We selected most pathways NLRP2 participated on our site, such as NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NOD pathwayNLRP10;NLRP4;PRDM1;COPS6;AAMP;NLRP2;NLRP7;SUGT1;NLRP3

NLRP2 has several biochemical functions, for example, ATP binding, Pyrin domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP2 itself. We selected most functions NLRP2 had, and list some proteins which have the same functions with NLRP2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAPKAPK2A;ACSF3;MAP4K6;TAP1;MAP2K7;GSK3A;PI4KB;ACTA1B;AKT3
Pyrin domain bindingPYCARD;NLRP2;CASPA
protein bindingRBM12B;DHRS1;ARF5;CD82;DOCK10;FYB;BLOC1S4;SGCG;C10orf119

NLRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP2.

PYDC2; H2AFX; WRN; RBBP6; BECN1; TPP1; NLRP5; TTF1; TAF13; BCL7B; CRIPT

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