NMNAT2
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Official Full Name
nicotinamide nucleotide adenylyltransferase 2
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Overview
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NMNAT2; nicotinamide nucleotide adenylyltransferase 2; C1orf15, chromosome 1 open reading frame 15; nicotinamide mononucleotide adenylyltransferase 2; KIAA0479; PNAT2; C1orf15; MGC2756; NaMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NMNA2_HUMAN; NMNAT 2; PNAT 2; Pyridine nucleotide adenylyltransferase 2; OTTHUMP00000033548; OTTHUMP00000033549;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NMNAT2 involved in several pathways and played different roles in them. We selected most pathways NMNAT2 participated on our site, such as Nicotinate and nicotinamide metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMNAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Nicotinate and nicotinamide metabolism | NT5E;NMRK1;NMRK2;PNP5A;NADKA;NT5C2;NAPRT;NT5C3A;NADK2 |
Metabolic pathways | CYP2P6;CYP2S1;CYP3A5;NDUFC1;CKB;RPN2;ALDH3A1;PIGB;AHCYL2 |
NMNAT2 has several biochemical functions, for example, ATP binding, nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMNAT2 itself. We selected most functions NMNAT2 had, and list some proteins which have the same functions with NMNAT2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | DARS2;FGFR2;PSMC2;AK7B;DYNC1LI1;PDK4;SYN2B;PSMC5;STK4 |
nicotinamide-nucleotide adenylyltransferase activity | NMNAT1;NMNAT2;NMNAT3 |
nicotinate-nucleotide adenylyltransferase activity | NMNAT1;NMNAT2;NMNAT3;ABL1 |
NMNAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMNAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMNAT2.
- Q&As
- Reviews
Q&As (5)
Ask a questionNMNAT2 is part of a network of proteins involved in neuroprotection, and understanding these interactions may provide insights into potential therapeutic strategies.
It's essential to check the latest clinical trial databases for updated information, as ongoing trials may be exploring the therapeutic potential of NMNAT2.
Some studies suggest a connection between NMNAT2 and conditions like Alzheimer's disease, making it a potential target for therapeutic interventions.
As NMNAT2 is associated with NAD+ production, its clinical application may have implications for addressing age-related decline in cellular function and overall health.
Some studies suggest that certain dietary interventions, such as those affecting NAD+ levels, may indirectly influence NMNAT2 activity.
Customer Reviews (3)
Write a reviewIt reliably and accurately detects and quantifies target molecules, allowing for precise measurement of analytes in my samples.
The NMNAT2 Protein consistently produces well-defined and interpretable structural data, enabling me to unravel complex macromolecular assemblies and their mechanisms.
The sensitivity and specificity of the NMNAT2 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.
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