NONO
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Official Full Name
non-POU domain containing, octamer-binding
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Overview
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009] -
Synonyms
NONO; non-POU domain containing, octamer-binding; P54; NMT55; NRB54; P54NRB; non-POU domain-containing octamer-binding protein; p54(nrb); 55 kDa nuclear protein; 54 kDa nuclear RNA- and DNA-binding protein; DNA-binding p52/p100 complex, 52 kDa subunit; non-POU domain-containing octamer (ATGCAAAT) binding protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
NONO involved in several pathways and played different roles in them. We selected most pathways NONO participated on our site, such as Circadian rhythm pathway, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with NONO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Circadian rhythm pathway | CHEK1;DEC1;TIMELESS;NONO |
mRNA processing | ZFP740;SUGP2;CD2BP2;RAVER1;CLK1;ADAM5;HNRNPH1;SFRS3A;OASL2 |
NONO has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NONO itself. We selected most functions NONO had, and list some proteins which have the same functions with NONO. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II distal enhancer sequence-specific DNA binding | GATA2;TAL1;NR5A2;CREB1;H2AFZ;PAX4;NFE2L1;HOXB5;RUVBL2 |
chromatin binding | MSL1;CDK9;AAAS;BEND6;SREBF1;MEF2A;HIF1AB;DNMT1;ARX |
core promoter binding | CRY1;IFI16;MYOG;MYBBP1A;NKX3;NEUROG3;E2F2;CCAR1;ELK4 |
identical protein binding | UBQLN1;GDF5;SF1;ALK;STIM1;CHEK2;STK10;LCP1;SH3GL1 |
nucleotide binding | PRKACBA;SNRNP35;Abca2;CAMK2G1;DNAHC8;MAP2K4A;HNRNPAB;EIF4A1B;HIPK3A |
poly(A) RNA binding | NSUN5;ZFP207;FAU;RPL3;DDX5;MEX3B;MRPL42;DHX32;RPS6 |
protein binding | BLCAP;ATP5F1;C19orf44;RNF4;Ctsl;MVK;TBATA;LEO1;ELK1 |
transcription regulatory region sequence-specific DNA binding | NKX3;NFE2L3;BACH1B;NR5A2;NR5A1;NKX3-1;SOX2;SUV39H2;NR5A1B |
NONO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NONO here. Most of them are supplied by our site. Hope this information will be useful for your research of NONO.
PSPC1; PIN1; RNF43
- Q&As
- Reviews
Q&As (6)
Ask a questionThis protein is widely expressed in a variety of tissues and organs, including the brain, heart, liver, kidneys, and muscles.
Yes, NONO protein is involved in the regulation of RNA splicing and plays an important role in the splicing process by interacting with other proteins.
NONO protein is expressed in the liver and is involved in the regulation of signaling pathways related to liver function. However, further research is needed to determine its specific role.
NONO protein interacts with DNA repair-related proteins and is involved in the repair process of DNA double-strand breaks.
The protein has been implicated in some neurological diseases, such as motor neuron disease, but its specific role and mechanism still need to be further studied.
NONO protein has been implicated in a variety of diseases, including leukemia, neurological diseases such as motor neuron disease, and progeria.
Customer Reviews (3)
Write a reviewThe stability of NONO has good adaptability under different temperature and pH conditions.
NONO has important application value in the field of drug research and development, and has achieved certain research results.
Experiments with NONO are easy to use and do not require complex procedures.
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