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NONO

  • Official Full Name

    non-POU domain containing, octamer-binding

  • Overview

    This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
  • Synonyms

    NONO; non-POU domain containing, octamer-binding; P54; NMT55; NRB54; P54NRB; non-POU domain-containing octamer-binding protein; p54(nrb); 55 kDa nuclear protein; 54 kDa nuclear RNA- and DNA-binding protein; DNA-binding p52/p100 complex, 52 kDa subunit; non-POU domain-containing octamer (ATGCAAAT) binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NONO-28748TH Recombinant Human NONO, His-tagged E.coli His
Human NONO-851H Recombinant Human NONO protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NONO-852H Recombinant Human NONO protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NONO-853H Recombinant Human NONO protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NONO-854H Recombinant Human NONO protein, GST-tagged Wheat Germ GST
Human NONO-1332H Recombinant Human NONO protein, His-sumo-tagged E.coli His/SUMO 1-471 aa
Human NONO-3766HCL Recombinant Human NONO 293 Cell Lysate HEK293 N/A
Human NONO-1688H Recombinant Human NONO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NONO-691H Recombinant Human NONO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NONO-4523H Recombinant Human NONO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NONO-2496HB Recombinant Human NONO Protein, His tagged, Avi-Biotinylated E.coli His
Human NONO-2496H Recombinant Human NONO Protein, His-tagged E.coli N-His Lys18-Asp228
Human NONO-2684HFL Recombinant Full Length Human NONO protein, Flag-tagged Mamanlian cells Flag
Human NONO-2497H Recombinant Human NONO Protein, His tagged, Avi-Biotinylated E.coli N-His
Human NONO-4445H Recombinant Human NONO protein, His-tagged E.coli His 1-471aa
Mouse Nono-4458M Recombinant Mouse Nono Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat NONO-4020R Recombinant Rat NONO Protein Mammalian Cell His
Rat NONO-3679R Recombinant Rat NONO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NONO-3679R-B Recombinant Rat NONO Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NONO-3066R Recombinant Rhesus monkey NONO Protein, His-tagged Mammalian Cell His
Rhesus Macaque NONO-2885R-B Recombinant Rhesus Macaque NONO Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NONO-2885R Recombinant Rhesus Macaque NONO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NONO-11561Z Recombinant Zebrafish NONO Mammalian Cell His
Chicken NONO-3176C Recombinant Chicken NONO Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NONO involved in several pathways and played different roles in them. We selected most pathways NONO participated on our site, such as Circadian rhythm pathway, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with NONO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Circadian rhythm pathwayCHEK1;DEC1;TIMELESS;NONO
mRNA processingZFP740;SUGP2;CD2BP2;RAVER1;CLK1;ADAM5;HNRNPH1;SFRS3A;OASL2

NONO has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NONO itself. We selected most functions NONO had, and list some proteins which have the same functions with NONO. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II distal enhancer sequence-specific DNA bindingGATA2;TAL1;NR5A2;CREB1;H2AFZ;PAX4;NFE2L1;HOXB5;RUVBL2
chromatin bindingMSL1;CDK9;AAAS;BEND6;SREBF1;MEF2A;HIF1AB;DNMT1;ARX
core promoter bindingCRY1;IFI16;MYOG;MYBBP1A;NKX3;NEUROG3;E2F2;CCAR1;ELK4
identical protein bindingUBQLN1;GDF5;SF1;ALK;STIM1;CHEK2;STK10;LCP1;SH3GL1
nucleotide bindingPRKACBA;SNRNP35;Abca2;CAMK2G1;DNAHC8;MAP2K4A;HNRNPAB;EIF4A1B;HIPK3A
poly(A) RNA bindingNSUN5;ZFP207;FAU;RPL3;DDX5;MEX3B;MRPL42;DHX32;RPS6
protein bindingBLCAP;ATP5F1;C19orf44;RNF4;Ctsl;MVK;TBATA;LEO1;ELK1
transcription regulatory region sequence-specific DNA bindingNKX3;NFE2L3;BACH1B;NR5A2;NR5A1;NKX3-1;SOX2;SUV39H2;NR5A1B

NONO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NONO here. Most of them are supplied by our site. Hope this information will be useful for your research of NONO.

PSPC1; PIN1; RNF43

  • Q&As
  • Reviews

Q&As (6)

Ask a question
In which tissues or organs is NONO protein highly expressed? 06/15/2022

This protein is widely expressed in a variety of tissues and organs, including the brain, heart, liver, kidneys, and muscles.

Is NONO protein involved in RNA splicing regulation? 03/24/2022

Yes, NONO protein is involved in the regulation of RNA splicing and plays an important role in the splicing process by interacting with other proteins.

Is NONO protein involved in liver function? 02/08/2022

NONO protein is expressed in the liver and is involved in the regulation of signaling pathways related to liver function. However, further research is needed to determine its specific role.

Is there a relationship between NONO protein and DNA damage repair? 01/10/2022

NONO protein interacts with DNA repair-related proteins and is involved in the repair process of DNA double-strand breaks.

What is the role of NONO protein in neurological diseases? 11/30/2021

The protein has been implicated in some neurological diseases, such as motor neuron disease, but its specific role and mechanism still need to be further studied.

What diseases are NONO associated with? 01/21/2021

NONO protein has been implicated in a variety of diseases, including leukemia, neurological diseases such as motor neuron disease, and progeria.

Customer Reviews (3)

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Reviews
08/08/2023

    The stability of NONO has good adaptability under different temperature and pH conditions.

    04/01/2022

      NONO has important application value in the field of drug research and development, and has achieved certain research results.

      04/01/2020

        Experiments with NONO are easy to use and do not require complex procedures.

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