nono
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  • Official Full Name
  • non-POU domain containing, octamer-binding
  • Background
  • This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]
  • Synonyms
  • NONO; non-POU domain containing, octamer-binding; P54; NMT55; NRB54; P54NRB; non-POU domain-containing octamer-binding protein; p54(nrb); 55 kDa nuclear protein; 54 kDa nuclear RNA- and DNA-binding protein; DNA-binding p52/p100 complex, 52 kDa subunit; non-POU domain-containing octamer (ATGCAAAT) binding protein;
Cat.#:NONO-1332HTag:His/SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NONO protein, His-sumo-tagged
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Cat.#:NONO-28748THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NONO, His-tagged
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Cat.#:NONO-851HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NONO protein, MYC/DDK-tagged
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Cat.#:NONO-852HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NONO protein, MYC/DDK-tagged
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Cat.#:NONO-853HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NONO protein, MYC/DDK-tagged
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Cat.#:NONO-854HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NONO protein, GST-tagged
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Cat.#:NONO-4020RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NONO Protein
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Cat.#:NONO-3066RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NONO Protein, His-tagged
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Cat.#:NONO-3176CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NONO
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Cat.#:NONO-11561ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NONO
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Cat.#:NONO-3766HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NONO 293 Cell Lysate
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Involved Pathway

NONO involved in several pathways and played different roles in them. We selected most pathways NONO participated on our site, such as Circadian rhythm pathway, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with NONO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Circadian rhythm pathway
TIMELESS; DEC1; CHEK1; NONO
mRNA processing
HNRNPD; CELF2; SUGP2; PRPF4B; ADAM5; PPM1G; MCTS2; ZFML; DHX15; METTL3

Protein Function

NONO has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NONO itself. We selected most functions NONO had, and list some proteins which have the same functions with NONO. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein MEOX2; ARID3B; SPI1; NR5A2; RELA; NFE2L2; NFATC1; POU4F1; NFKB1; PROP1
Function chromatin binding
Related Protein MBD1; MTA1; TDRD3; NCAPD3; MITF; EOMES; NKX6-1; NSD1; LOXL2; SSBP1
Function core promoter binding
Related Protein GATA1; ELK1; HDAC4; E2F2; MYOG; ARNTL; SPI1; E2F3; XBP1; CLOCK
Function identical protein binding
Related Protein DVL1; ZHX2; PRC1; KHDRBS1; CCDC155; KLHL7; HGF; PVRL2; KRTAP10-5; POU3F2
Function nucleotide binding
Related Protein LARP6; CLK4B; DYNC2H1; PPIP5K2; FYNB; Aatk; LOC81691; FGFR1A; PSMC1A; MAT2AL
Function poly(A) RNA binding
Related Protein ATP5A1; RPL30; PTCD1; PDCD11; LSM4; TMSB4X; APEX1; SRP68; RPL7; YTHDF2
Function protein binding
Related Protein ARHGEF7; HOOK2; DOK1; UBE2M; HMMR; HSPA1B; NOP58; AGBL4; MIEN1; ZNF238
Function transcription regulatory region sequence-specific DNA binding
Related Protein PER2; SOX4; NR5A1A; NFE2L2; SOX2; CREB3L3; ATF3; MEF2AA; SUV39H1; CRY2

Interacting Protein

NONO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NONO here. Most of them are supplied by our site. Hope this information will be useful for your research of NONO.
PSPC1; PIN1; RNF43