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NPEPPS

  • Official Full Name

    aminopeptidase puromycin sensitive

  • Overview

    This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle.
  • Synonyms

    NPEPPS; aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100; MP100; PSA; puromycin sensitive aminopeptidase; METALLOPROTEASE 100; METALLOPROTEASE MP100; MP 100; OTTHUMP00000229852; OTTHUMP00000229855; cytosol alanyl aminopeptidase; AAP-S;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|S
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NPEPPS-1158H Recombinant Human NPEPPS protein, His-tagged E.coli His Gly584~Gln793
Human NPEPPS-6023H Recombinant Human NPEPPS Protein, GST-tagged Wheat Germ GST
Human NPEPPS-2245H Recombinant Human NPEPPS protein, His&Myc-tagged Insect Cell His&Myc 53-504aa
Human NPEPPS-2500H Recombinant Human NPEPPS Protein, His-tagged E.coli N-His Thr141-Val272
Human NPEPPS-3284H Recombinant Human NPEPPS protein, His-tagged E.coli His 53-504aa
Human NPEPPS-3425H Recombinant Human NPEPPS Protein (Gly584-Gln793), His tagged E.coli His Gly584-Gln793
Human NPEPPS-2789H Recombinant Human NPEPPS protein(71-150 aa), C-His-tagged E. coli C-His 71-150 aa
Mouse NPEPPS-10815M Recombinant Mouse NPEPPS Protein Mammalian Cell His
Mouse Npepps-1160M Recombinant Mouse Npepps protein, His & S-tagged E.coli His/S Leu584~His755 (Accession # Q11011)
Mouse NPEPPS-6155M Recombinant Mouse NPEPPS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NPEPPS-6155M-B Recombinant Mouse NPEPPS Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NPEPPS-7569Z Recombinant Zebrafish NPEPPS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NPEPPS Related Articles
  • NPEPPS Related Research Area

NPEPPS involved in several pathways and played different roles in them. We selected most pathways NPEPPS participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPEPPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemTREM1;AP2A1;ITPR2;VPRBP;CD300E;AP1S1;RNF41;THEM4;FRS2A
Antigen processing: Ubiquitination &ampLRSAM1;UBR1;ASB11;RNF182;WSB1;RNF14;FBXO27;PJA1;ASB8
Proteasome degradationLRR1;HECTD3;LRRC41;TRIM69;WWP1;ASB2;RNF34;PJA1;TRIM9
Class I MHC mediated antigen processing &ampRBCK1;GAN;RNF41;CD207;NPEPPS;RNF25;WWP1;RNF123;ASB9
presentationASB11;RNF6;RNF220;FCGR1B;SPSB4;DZIP3;ERAP1;UBE2E3;ASB2
Immune SystemBTR09;FCN3;LRRC41;BTR16;RNF144B;LILRA1;EDAR;TAX1BP1B;FCN2

NPEPPS has several biochemical functions, for example, aminopeptidase activity, hydrolase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPEPPS itself. We selected most functions NPEPPS had, and list some proteins which have the same functions with NPEPPS. You can find most of the proteins on our site.

Function Related Protein
aminopeptidase activityLTA4H;LAP3;METAP1;LNPEP;XPNPEP1;ERAP2;CTSL2;METAP2A;PHEX
hydrolase activityPTPRUB;TMPRSS13B;CASPBL;F9A;CELL;PSMB9A;ZRANB3;MMP1A;SETX
metal ion bindingZBTB10;STK32C;SNAI2;SIAH1A;ZNF683;FGD2;CYBASC3;GNAT2;NCALDB
metallopeptidase activityANPEPB;MEP1A.1;MMP1A;ADAM23;CPD;AQPEP;MMP2;AFG3L2;ADAM10A
peptidase activityCTS7;CTSL1B;Ren1;Gzmg;PM20D1.2;ELANE;OTUD7A;F2RL1.1;ESPL1
zinc ion bindingMID1;ERI2;TRAF4A;ZRANB2;MMP24;RANBP2;RC3H1;ZIM2;MID2

NPEPPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPEPPS here. Most of them are supplied by our site. Hope this information will be useful for your research of NPEPPS.

Ywhae; Dlg4

Lee, S; Shea, TB; et al. Regulation of tau proteolysis by phosphatases. BRAIN RESEARCH 1495:30-36(2013).
Chow, KM; Guan, HJ; et al. Aminopeptidases do not directly degrade tau protein. MOLECULAR NEURODEGENERATION 5:-(2010).
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