NPHS1
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Official Full Name
nephrosis 1, congenital, Finnish type (nephrin)
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Overview
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009] -
Synonyms
NPHS1; nephrosis 1, congenital, Finnish type (nephrin); CNF; NPHN; nephrin; nephrin; renal glomerulus-specific cell adhesion receptor;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|GST
- His|T7
- N/A
- N
- SUMO
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NPHS1-5640H | Recombinant Human NPHS1 protein, His & T7-tagged | E.coli | His/T7 | His705~Ser1055 (Accession # O60500) |
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| Human | NPHS1-29301TH | Recombinant Human NPHS1 | Wheat Germ | N/A | 90 amino acids |
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| Human | NPHS1-2475H | Recombinant Human NPHS1 protein(441-630 aa), N-SUMO & C-His-tagged | E. coli | N-SUMO & C-His | 441-630 aa |
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| Human | NPHS1-6031H | Recombinant Human NPHS1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | NPHS1-689H | Recombinant Human NPHS1 Protein (23-257 aa), His-tagged | E.coli | His | 23-257 aa |
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| Human | NPHS1-4726H | Recombinant Human NPHS1 Protein (Pro89-Trp374), N-His tagged | E.coli | N-His | Pro89-Trp374 |
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| Human | NPHS1-5044H | Recombinant Human NPHS1 protein, His-tagged | HEK293 | His | 23-257aa |
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| Human | NPHS1-3581H | Recombinant Human NPHS1 protein, His-tagged | E.coli | His | 89-374 aa | |
| Human | NPHS1-2474H | Recombinant Human NPHS1 protein(1131-1220 aa), C-His-tagged | E. coli | C-His | 1131-1220 aa |
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| Human | NPHS1-1843H | Recombinant Human NPHS1 Protein, His&GST-tagged | E.coli | N-His&GST | Arg1160-Val1241 |
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| Mouse | Nphs1-16M | Active Recombinant Mouse Nphs1, His-tagged | Mammalian cells | His |
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| Mouse | Nphs1-718M | Active Recombinant Mouse Nphs1 Protein, His-tagged | Mammalian cells | His | Gln37-Thr1049 |
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| Mouse | NPHS1-10822M | Recombinant Mouse NPHS1 Protein | Mammalian Cell | His |
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| Mouse | Nphs1-5641M | Recombinant Mouse Nphs1 protein, His-tagged | E.coli | His | Pro39~Ser144 (Accession # Q9QZS7) |
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| Mouse | Nphs1-1343M | Recombinant Mouse Nphs1, GST-tagged | E.coli | GST | 640-767aa | |
| Mouse | Nphs1-6162M | Recombinant Mouse Nphs1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Nphs1-6162M-B | Recombinant Mouse Nphs1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | NPHS1-4042R | Recombinant Rat NPHS1 Protein | Mammalian Cell | His |
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| Rat | Nphs1-5642R | Recombinant Rat Nphs1 protein, His & GST-tagged | E.coli | His/GST | Pro39~Gly106 (Accession # Q9R044) |
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| Rat | NPHS1-3701R | Recombinant Rat NPHS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | NPHS1-3701R-B | Recombinant Rat NPHS1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | NPHS1-3815Z | Recombinant Zebrafish NPHS1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- NPHS1 Related Articles
NPHS1 involved in several pathways and played different roles in them. We selected most pathways NPHS1 participated on our site, such as Cell-Cell communication, Nephrin interactions, Nephrin/Neph1 signaling in the kidney podocyte, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPHS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell-Cell communication | CLDN3;CDH7;CLDN20;CDH4;CDH12;SIRPB1;LIMS1;RSU1;CDH17 |
| Nephrin interactions | NPHS1;KIRRELB;KIRREL2;KIRREL3;KIRREL3L;KIRRELA;KIRREL |
| Nephrin/Neph1 signaling in the kidney podocyte | KIRREL;NPHS1 |
NPHS1 has several biochemical functions, for example, myosin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPHS1 itself. We selected most functions NPHS1 had, and list some proteins which have the same functions with NPHS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| myosin binding | DMD;ARFGEF2;CALD1;CALM;STX4A;NPHS1;VETZ;VAMP2;ACTA1 |
| protein binding | Trl;TP73;MFAP4;IL18;TSEN2;KCNH2;HP1BP3;UNG;MEI4 |
NPHS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPHS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPHS1.
IQGAP1; NCK1; NCK2; Was; tenA; eno; ALB
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations in the NPHS1 gene cause a decrease in nephrin protein and abnormal distribution.
NPHS1 expression is downregulated in diabetic nephropathy tissues.
LPS silences NPHS1 gene expression through histone H3K9 dimethylation.
Expression of lncRNA CRNDE negative correlation with NPHS1.
NPHS1 is closely associated with the study of multiple kidney diseases.
Customer Reviews (3)
Write a reviewProfessional personnel to provide after-sales service, experimental results are guaranteed.
High protein concentration, good quality, worth buying.
The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.
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