Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

NRXN2

Official Full Name

neurexin 2
Overview

This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules;and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are;produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are;produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth;factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The;beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing;and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID:;11944992).
Synonyms

NRXN2; neurexin 2; FLJ40892; KIAA0921; neurexin-2-beta; neurexin II; neurexin II-beta; neurexin-2-alpha; neurexin II-alpha;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NRXN2-055H	Active Recombinant Human Neurexin 2 Fc-tagged	CHO	Fc		Inquiry
Rat	NRXN2-4087R	Recombinant Rat NRXN2 Protein	Mammalian Cell	His		Inquiry
Rat	NRXN2-3748R	Recombinant Rat NRXN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NRXN2-3748R-B	Recombinant Rat NRXN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL19967HF	Recombinant Full Length Human Neurexin-2-Beta(Nrxn2) Protein, His-Tagged	E.coli expression system	His	Full Length (51-666)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
NRXN2 Related Articles
NRXN2 Related Research Area

NRXN2 involved in several pathways and played different roles in them. We selected most pathways NRXN2 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with NRXN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell adhesion molecules (CAMs)	HLA-DRB4;VCAN;CDH1;CLDNH;NCAM1B;NCAM1;CADM1B;CLDN19;HLA-DMB

NRXN2 has several biochemical functions, for example, calcium channel regulator activity, cell adhesion molecule binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRXN2 itself. We selected most functions NRXN2 had, and list some proteins which have the same functions with NRXN2. You can find most of the proteins on our site.

Function	Related Protein
calcium channel regulator activity	Crisp4;NPY2R;NRXN1;TSPAN13;STIM2;TSPAN13B;CACNB2;TSPAN13A;GRM2A
cell adhesion molecule binding	FGG;VCAM1;CADM1A;ITGB7;CD200;LPHN1;Fert2;NRXN3;PVRL3
metal ion binding	NR6A1B;ZNF238;USP19;PTGS2;NUBPL;GNAI1;ZFP710;IDI2;ZFP64
neuroligin family protein binding	NRXN2;DLG4;NRXN1;NRXN3
transmembrane signaling receptor activity	TNFRSF10C;GHRHR2;CD97;FZD8B;OR2A4;KLRB1;SEMA4D;OR103-4;NRXN1

NRXN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRXN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRXN2.

MAPK6

Traunmuller, L; Bornmann, C; et al. Alternative Splicing Coupled Nonsense-Mediated Decay Generates Neuronal Cell Type-Specific Expression of SLM Proteins. JOURNAL OF NEUROSCIENCE 34:16755-16761(2014).

Dachtler, J; Glasper, J; et al. Deletion of alpha-neurexin II results in autism-related behaviors in mice. TRANSLATIONAL PSYCHIATRY 4:-(2014).

Neurexins and Neuroligins

Synaptic Adhesion Molecules