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SOS1

Official Full Name

son of sevenless homolog 1 (Drosophila)
Overview

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Synonyms

SOS1; son of sevenless homolog 1 (Drosophila); GF1; HGF; NS4; GGF1; GINGF; son of sevenless homolog 1; SOS-1; guanine nucleotide exchange factor; gingival fibromatosis, hereditary, 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SOS1-1568HCL	Recombinant Human SOS1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SOS1-13H	Recombinant Human SOS1 Protein, His-tagged	E.coli	His		Inquiry
Human	SOS1-38H	Active Recombinant Human SOS1 Protein (564-1049), N-His tagged	E.coli	N-His	564-1049	Inquiry
Zebrafish	SOS1-5322Z	Recombinant Zebrafish SOS1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SOS1 Related Signal Pathway

SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	MAX;TGFBR1A;CD14;FGFR1;MAPK8IP2;CACNA1SA;PLA2G4A;MAPK8B;TRP53
ErbB signaling pathway	GSK3B;RPS6KB2;PRKCB;PAK3;BTC;ARAF;PAK1;TGFA;MAPK1
Ras signaling pathway	RHOA;PDGFC;FLT4;PLA2G4C;PRKCG;AKT1;PLA2G2E;GNB1;CALM2
Chemokine signaling pathway	PIK3CB;GM1987;CCR7;CXCL13;RAF1;CCL3;BRAF;CCL18;CCL7
FoxO signaling pathway	PIK3R2;GADD45BB;IGF1RB;NLK1;BRAF;INSRA;IKBKB;CDKN2B;FOXG1
Phospholipase D signaling pathway	PLA2G4C;GAB1;CYTH2;RALGDS;CYTH4;AVPR1B;DGKE;GRM8;MAPK1
PIK-Akt signaling pathway	CCNE1;Gh;FGF11;RPS6KB1;LPAR5;PRL;TSC2;AKT1;OSM
Dorso-ventral axis formation	NOTCH1A;GRB2;CPEB1A;ETS1;PIWIL1;FMN2;ETV6;EGFRA;CPEB1
Focal adhesion	CCND1;COL27A1B;COL6A6;FYNA;CAV3;IGF1RB;BCL2A;RAC3;LAMB1A
Gap junction	PRKCBA;TUBA3D;MAP2K2B;PDGFB;PDGFC;TUBB5;ADRB3B;ITPR1;TJP1
Jak-STAT signaling pathway	PIK3CG;HRASB;IL6R;LIFRA;IL11RA;STAT5B;GM13305;AKT2L;EP300
Natural killer cell mediated cytotoxicity	IFNA16;GZMB;FASLG;IFNA1;SHC2;IFNGR1;PTK2B;IFNA2;KLRA8
T cell receptor signaling pathway	PAK6;MAPK3;MAP2K7;CARD11;EVLB;CD3E;NFKBIE;PIK3R1;MAPK9
B cell receptor signaling pathway	RAC3;CD22;PILRB;HRAS;CD19;VAV2;SLA2;cgr2b;NFKBIB
Fc epsilon RI signaling pathway	MAPK13;GAB2;FCER1A;PLCG1;PIK3R1;MAPK9;HRAS;PLA2G4B;NRAS
Neurotrophin signaling pathway	TRAF6;CAMK2B;PRDM4;ZNF274;NGFRAP1;FASLG;PIK3R3;SHC4;RAP1B
Regulation of actin cytoskeleton	RHOAA;MSNB;IQGAP3;MYLK3;CYFIP1;PIP4K2A;ACTN2B;PFN2L;SLC9A1
Insulin signaling pathway	PRKAR1B;SREBF1;PPP1CB;SOS1;INSRA;EIF4EA;CBLC;GSK3B;PYGM
GnRH signaling pathway	GNA11B;CACNA1SB;PLA2G4F;PRKCBB;CALM1A;Adcy4;GNAS;GNRHR1;PLD2
Estrogen signaling pathway	MAPK3;ESR1;RAF1;CREB3L3;MAPK1;HSPA2;PRKACA;PIK3R2;PIK3CA
Prolactin signaling pathway	MAPK10;PIK3CA;RELA;CSN2;SHC2;CCND2;STAT5A;SHC4;ESR1
Alcoholism	NTRK2;GNB4;GNG4;HIST1H2BC;HDAC7A;H2AFV;HDAC5;HIST1H2BL;HIST1H2BO
Hepatitis C	PIAS1;AKT1;MAVS;OCLN;KRAS;RIPK1;HRAS;OAS3;BAD
Pathways in cancer	NRAS;TCF7;FGF6;BCL2;PLCG2;WNT9A;Flt3l;PTGER4;PIAS2
Proteoglycans in cancer	IGF1;PAK1;PIK3R2;TP53;TIMP3;WNT5B;WNT7B;FZD1;WNT7A
MicroRNAs in cancer	FZD3;DNMT3B;CDCA5;SERPINB5;TNXB;APC2;HNRNPK;PRKCA;ABCC1
Renal cell carcinoma	CUL2;ARAF;PDGFB;EPAS1;EGLN1;RAF1;TCEB1;TCEB2;KRAS
Endometrial cancer	ELK1;CDH1;RAF1;AKT2;PDPK1;TCF7;CTNNA2;SOS1;CTNNA3
Glioma	NRAS;IGF1;PLCG1;TP53;ARAF;CCND1;SHC3;PRKCA;PIK3CB
Prostate cancer	ACTL6B;HRAS;PIK3CA;NRAS;NKX3;BCL2;PIK3R3;INS;SPINK1
Chronic myeloid leukemia	MDM2;KRAS;MAPK1;MAP2K2;SMAD4;ARAF;HDAC1;HRAS;NFKBIA
Acute myeloid leukemia	SPI1;PML;CHUK;RARA;BRAF;GRB2;STAT5A;PIK3CA;RPS6KB2
Non-small cell lung cancer	TP53;ERBB2;ARAF;FOXO3;PRKCG;MAPK1;TGFA;NRAS;PDPK1
Choline metabolism in cancer	RALGDS;RAC2;PPAP2C;PDGFC;PLD2;RPS6KB1;MAP2K1;SLC22A1;MAPK9

SOS1 has several biochemical functions, for example, DNA binding, GTPase activator activity, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	SSBP3A;ZNF785;HNF1BB;MEF2CA;TOP2A;ZNF45;KDM1B;HIST1H2BP;ZNF75A
GTPase activator activity	RGS3A;TBC1D16;ARAP3;FAM13B1;RGS20;GIT2B;SRGAP3;DEPDC1A;ARHGEF15
Ras guanyl-nucleotide exchange factor activity	ADRB1;RAPGEF4;RASGRP1;RASGRP4;KNDC1;RGL2;RASGEF1B;RASGEF1BB;RASGEF1A
Rho guanyl-nucleotide exchange factor activity	DOCK11;PLEKHG3;FGD2;ITSN1;ARHGEF37;ALS2CL;PLEKHG2;ITSN2A;ARHGEF40
SH3 domain binding	MICAL1;NCKIPSD;QKIA;ABL1;ELMO3;SOS1;FUT8;AFAP1L2;INPP5J
protein binding	HNRPLL;BCL2A1A;AARSD1;TRIM31;PTPN11A;DOK2;KRTAP19-7;EFHC1;IGF2BP3
protein heterodimerization activity	GABRR1;BOK;GABPB1;VEGFA;HIST1H4A;NFYB;CHRNA3;PANX1;CABYR

SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.

GRB2