NSD1
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Official Full Name
nuclear receptor binding SET domain protein 1
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Overview
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
NSD1; nuclear receptor binding SET domain protein 1; Sotos syndrome , STO; histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; ARA267; FLJ22263; KMT3B; H3-K36-HMTase; H4-K20-HMTase; lysine N-methyltransferase 3B; NR-binding SET dom;
- Recombinant Proteins
- Assay Kits
- Human
- E. coli
- E.coli
- Insect Cell
- GST
- His
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | NSD1-03H | Active Recombinant Human NSD1 protein, GST-tagged | E.coli | GST | 1852-2082aa | |
Human | NSD1-82H | Recombinant Human NSD1, GST-tagged | E.coli | GST | ||
Human | NSD1-143H | Recombinant Human NSD1 Protein, His-tagged | Insect Cell | His | 1538-2696 | |
Human | NSD1-035H | Recombinant Human NSD1 Protein, GST-tagged | E. coli | GST | 1700-1986 | |
Human | NSD1-002H | Recombinant Human NSD1 Protein, GST-tagged | E.coli | GST | 1700-1986 | |
Human | NSD1-2813H | Recombinant Human NSD1 protein, His-tagged | E.coli | His | 341-630 aa | |
Kit-1787 | NSD1 Chemiluminescent Assay Kit | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- NSD1 Related Articles
NSD1 involved in several pathways and played different roles in them. We selected most pathways NSD1 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Lysine degradation | PLOD1;ALDH2;PIPOX;SETDB1B;SETD8;ALDH2.1;SETD7;SUV420H1;SUV420H2 |
NSD1 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, androgen receptor binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSD1 itself. We selected most functions NSD1 had, and list some proteins which have the same functions with NSD1. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II core promoter sequence-specific DNA binding | ZFPM1;MITF;MTF1;RUNX2;TFAP2B;MAZ;STAT6;SMYD3;STAT5A |
androgen receptor binding | PARK7;PKN1;DAXX;FOXH1;PRMT2;KDM4C;WIPI1;RAN;NRIP1 |
chromatin binding | REL;CENPB;ANKRD17;NKX6;SMARCD1;ZFP143;HMGN5;ZFP932;SMC1AL |
estrogen receptor binding | CCDC62;DYX1C1;DDX17;NRIP1;STRN;NKX3-1;PCNA;WIPI1;FUS |
histone methyltransferase activity (H3-K36 specific) | SETD3;SMYD2A;SMYD2B;ASH1L;SMYD2;SETMAR;NSD1;SETD2 |
histone methyltransferase activity (H4-K20 specific) | SUV420H2;WHSC1;NSD1;SUV420H1 |
retinoic acid receptor binding | PRAME;MED1;CTBP2;PRMT2;AASS;LRIF1;PRAMEF1;PRAMEF6;SNW1 |
retinoid X receptor binding | VDR;NSD1;PPARG;NR0B2;RARG;FUS;NCOR1;HMGA1-RS1;MED25 |
thyroid hormone receptor binding | TAF11;GAS2L1;OASL;MED17;GTF2B;NR0B2;FUS;NCOR1;MED13 |
transcription cofactor activity | LDB2A;ZFP865;NSD1;LPXN;AIRE;TAF13;ANKRA2;ZFP710;KAT2B |
transcription corepressor activity | DAXX;RUNX1T1;TGIF1;NSD1;PSMC3;MXI1;HIRA;TBL1XR1;NR0B1 |
zinc ion binding | LHX1;TRIM43;ADAMTSL5;ZKSCAN5;TRIM3;ZFP37;ARIH1L;ANAPC11;ZNF622 |
NSD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSD1.
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