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NSMAF

  • Official Full Name

    neutral sphingomyelinase (N-SMase) activation associated factor

  • Overview

    This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
  • Synonyms

    NSMAF; neutral sphingomyelinase (N-SMase) activation associated factor; protein FAN; FAN; Factor associated with N SMase activation; Factor associated with neutral sphingomyelinase; Factor associated with neutral sphingomyelinase activation; Neutral sphingomyelinase (N SMase) activation associated factor; OTTHUMP00000226511; OTTHUMP00000226512; factor associated with N-SMase activation;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NSMAF-1374H Recombinant Human NSMAF, GST-tagged E.coli GST 568-917aa
Human NSMAF-524H Recombinant Human NSMAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NSMAF-1124H Recombinant Human NSMAF protein, His & GST-tagged E.coli His/GST Arg176~Arg575 (Accession # Q92636)
Human NSMAF-3686HCL Recombinant Human NSMAF 293 Cell Lysate HEK293 N/A
Human NSMAF-3800H Recombinant Human NSMAF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NSMAF-1844HFL Recombinant Full Length Human NSMAF protein, Flag-tagged Mamanlian cells Flag
Mouse NSMAF-10914M Recombinant Mouse NSMAF Protein Mammalian Cell His
Mouse NSMAF-6221M-B Recombinant Mouse NSMAF Protein Pre-coupled Magnetic Beads HEK293
Mouse Nsmaf-4510M Recombinant Mouse Nsmaf Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NSMAF-6221M Recombinant Mouse NSMAF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

NSMAF involved in several pathways and played different roles in them. We selected most pathways NSMAF participated on our site, such as Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSMAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid signaling pathwaySGMS1;SPTLC2;PRKCA;GNAI2;SPHK1;PTEN;ACER1;TRADD;RAF1

NSMAF has several biochemical functions, for example, phospholipid binding, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NSMAF itself. We selected most functions NSMAF had, and list some proteins which have the same functions with NSMAF. You can find most of the proteins on our site.

Function Related Protein
phospholipid bindingAPOEB;SERPINB1A;APOA5;CPS1;AMPH;SEC14L2;APOC3;F3;SHC1
protein bindingDDX39A;HSF1;CPSF4;NAE1;GPKOW;LIN9;ABLIM3;LRFN4;ACTN3
receptor signaling protein activityRAF1A;FLRT1;TRAIP;RGS12;FCAR;ARAF;DOK1;RAF1B;FLRT2

NSMAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSMAF here. Most of them are supplied by our site. Hope this information will be useful for your research of NSMAF.

GABARAPL1; GABARAP; VASP; ACTB; MAP1LC3A; GABARAPL2; MAP1LC3C; MAP1LC3B; XIRP2; KRT4; TNFRSF1A

  • Q&As
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